Cutaneous Infection with <i> Mycobacterium abscessus</i> in a Child

Brantley, Julie S.; Readinger, Allison; Morris, Elizabeth S.

doi:10.1111/j.1525-1470.2006.00196.x

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…However, recently, infections in immunocompetent persons have been reported more frequently. These cases are soft-tissue infections associated with trauma and injection and epidemics or pseudoepidemics that have occurred in hospitals (6,12). Ninety-five percent of soft-tissue RGM infections are caused by members of the M. chelonae complex (7), which comprises M. chelonae, M. abscessus, and M. immunogenum.…”

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confidence: 99%

Proportions of Mycobacterium massiliense and Mycobacterium bolletii Strains among Korean Mycobacterium chelonae-Mycobacterium abscessus Group Isolates

et al. 2008

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Korean isolates of the Mycobacterium chelonae-Mycobacterium abscessus group, which had been isolated from two different hospitals in South Korea, were identified by PCR restriction analysis (PRA) and comparative sequence analysis of 16S rRNA genes, rpoB, and hsp65 to evaluate the proportion of four closely related species (M. chelonae, M. abscessus, M. massiliense, and M. bolletii). Of the 144 rapidly growing mycobacterial strains tested, 127 strains (88.2%) belonged to the M. chelonae-M. abscessus group. In this group, M. chelonae, M. abscessus, M. massiliense, and M. bolletii accounted for 0.8% (n ‫؍‬ 1), 51.2% (n ‫؍‬ 65), 46.5% (n ‫؍‬ 59), and 1.6% (n ‫؍‬ 2), respectively. Two isolates which showed discordant results, M. massiliense by rpoB sequence analysis and M. abscessus by hsp65 sequence analysis, were finally identified as M. massiliense based on the additional analysis of sodA and the 16S-23S internal transcribed spacer. M. abscessus group I isolates previously identified by hsp65 PRA were all found to be M. abscessus, whereas group II isolates were further identified as M. massiliense or M. bolletii by sequencing of rpoB and hsp65. Smooth, rough, or mixed colonies of both M. abscessus and M. massiliense isolates were observed. M. massiliense strains that were highly resistant to clarithromycin had a point mutation at the adenine at position 2058 (A 2058 ) or 2059 (A 2059 ) in the peptidyltransferase region of the 23S rRNA gene.Rapidly growing mycobacteria (RGM), which include members of the Mycobacterium fortuitum complex, the M. chelonae complex, and the M. smegmatis complex, are defined as mycobacteria that grow and form visible colonies on solid agar media within 7 days. Because of their low virulence, they usually cause respiratory tract or disseminated infections in persons with predisposing factors or who are immunosuppressed (27,29,32). However, recently, infections in immunocompetent persons have been reported more frequently. These cases are soft-tissue infections associated with trauma and injection and epidemics or pseudoepidemics that have occurred in hospitals (6, 12). Ninety-five percent of soft-tissue RGM infections are caused by members of the M. chelonae complex (7), which comprises M. chelonae, M. abscessus, and M. immunogenum. However, the situation is complex for the clinical microbiologist who must rapidly and correctly identify isolates because there are reports of heterogeneity in M. abscessus isolates. Two M. abscessus groups (groups I and II) were reported on the basis of hsp65 PCR-restriction fragment length polymorphism (RFLP) (11) and sequence analysis (21) of hsp65. High heterogeneity of M. abscessus isolates was also shown by rpoB analysis (2). Meanwhile, new RGM species were reported: M. massiliense (4) and M. bolletii (1). These were very closely related to M. abscessus and M. chelonae but showed different susceptibility to clarithromycin, and their pathogenic potentials were shown by infections in immunocompetent and immunocompromised hosts (13,19).RGM infections are a...

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Proportions of Mycobacterium massiliense and Mycobacterium bolletii Strains among Korean Mycobacterium chelonae-Mycobacterium abscessus Group Isolates

et al. 2008

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“…To our knowledge, this is only the second description of an outbreak of skin infections by M. abscessus in a population of immunocompetent children due to nontraumatic transmission. Brantley et al reported a skin infection by M. abscessus in a child, most likely subsequent to exposure of a wound to pond water. Two other outbreaks including children were described after injections of contaminated drugs (penicillin and lidocaine) .…”

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confidence: 99%

Mycobacterium abscessus Hand‐and‐Foot Disease in Children: Rare or Emerging Disease?

Sinagra

Kanitz

Cerocchi

et al. 2014

Pediatric Dermatology

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Mycobacterium abscessus is emerging as an important cause of cutaneous infections in sporadic cases and outbreak settings. Although immunosuppressed or elderly patients are most commonly affected, in 2006 an outbreak of clinically distinct cutaneous lesions on the hands and feet caused by M. abscessus in a population of healthy children using a public swimming pool was reported. This article describes an outbreak of skin infection in a population of healthy Italian children attending the same school and using the same swimming pool. In January 2010 we identified three children with multiple, painful nodules on the palms and soles. M. abscessus was isolated from one child's lesions. A public health investigation was conducted and a team of dermatologists and public health officers visited all of the children; 514 children were screened and 29 cases were identified overall. All of the affected children had used the school's swimming pool. These children were treated with oral clarithromycin for 4 to 8 weeks. Because of the long period of time between the presentation and diagnosis of the first cases, the possibility that the number of cases may have been underestimated cannot be excluded. To our knowledge, this is the second largest reported cluster of M. abscessus skin infection suspected to be related to swimming pool exposure in a population of otherwise healthy children. It is unclear whether this disease is rare or should be considered as an emerging clinical entity.

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“…Hier sind z. B. Aufenthalt in Teichwasser [1], in einem Planschbecken [2], in Whirlpools [10,20,39], aber auch in öffentlichen Bädern [4] sowie Verletzungen im Wasser [12,40] bzw. durch Kontakt mit Fischen bzw.…”

Section: Epidemiologieunclassified

“…Als Subspezies von M. chelonae zählt auch M. abscessus zu diesem Komplex [1][2][3][4][5][6]. Weniger oft wurden M. avium-intracellulare [7][8][9][10], M. gordonae [11][12][13][14][15], M. haemophilum [16][17][18][19], M. intermedium [20], M. kansasii [21][22][23], M. malmoense [24][25][26][27], M. scrofulaceum [28,29], M. simiae [30], M. flavescens [31] und M. peregrinum [28] bei diesen Patienten nachgewiesen (auf M. ulcerans wird hier nicht eingegangen).…”

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Haut- und Weichgewebe-Infektionen durch nicht-tuberkulöse Mykobakterien: Ätiologie, Epidemiologie, Pathogenese, Klinik, Diagnostik, differenzialdiagnostische Aspekte und Empfehlungen für die Therapie

Nenoff¹,

Tchernev

Paasch

et al. 2011

Wien Med Wochenschr

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Non-tuberculous mycobacteria are rarely responsible for skin and soft tissue infections. These infections are caused by different mycobacterial species originating from the environment (water, soil, plants, and animals). Various factors influence the clinical manifestation of the cutaneous infection: the immunological situation of the patient, the degree of cutaneous impairment, and the extent of the contact with the contaminated environment. The clinical manifestation is non-specific and often the cause of extensive diagnostic activities. The diagnosis is based on the cultural detection of the causative pathogen. The management of these skin and subcutaneous infections is a challenge for each physician. The treatment comprises administration of several antibiotics and antituberculosis drugs for many months. Surgical procedures are necessary in some patients.

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Cutaneous Infection with Mycobacterium abscessus in a Child

Cited by 16 publications

References 18 publications

Proportions of Mycobacterium massiliense and Mycobacterium bolletii Strains among Korean Mycobacterium chelonae-Mycobacterium abscessus Group Isolates

Proportions of Mycobacterium massiliense and Mycobacterium bolletii Strains among Korean Mycobacterium chelonae-Mycobacterium abscessus Group Isolates

Mycobacterium abscessus Hand‐and‐Foot Disease in Children: Rare or Emerging Disease?

Haut- und Weichgewebe-Infektionen durch nicht-tuberkulöse Mykobakterien: Ätiologie, Epidemiologie, Pathogenese, Klinik, Diagnostik, differenzialdiagnostische Aspekte und Empfehlungen für die Therapie

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