Cutaneous infection caused by <i>Salmonella typhi</i>

Marzano, Angelo Valerio; Mercogliano, Maurizio; Borghi, Alessandro; Facchetti, Maura; Caputo, Ruggero

doi:10.1046/j.1468-3083.2003.00797.x

Cited by 24 publications

(11 citation statements)

References 13 publications

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“…It is a 2-8 mm, pink, blanching papule that is usually found on the anterior trunk in groups of 5-15 lesions. [30] They occur in up to 50% of patients with typhoid fever and less often in nontyphoidal enteric fever. Rose spots often occur in crops during the second to fourth weeks of the illness, and salmonella can usually be cultured from these lesions.…”

Section: Differential Diagnosismentioning

confidence: 99%

Mucocutaneous manifestations of dengue fever

2010

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Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. Cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesions may figure prominently in the clinical features of dengue. The differential diagnoses include a large number of bacterial and viral exanthems as well as drug rash.

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Section: Differential Diagnosismentioning

confidence: 99%

Mucocutaneous manifestations of dengue fever

2010

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“…1) required for bacterial motility of microorganisms such as Borrelia burgdorferi, which causes migratory erythema during the course of Lyme disease, or Salmonella typhi causing cutaneous ulceration [28]. Indeed, keratinocytes have been shown to upregulate chemokine expression in response to Borrelia burgdorferi indicating that this receptor is also functional on keratinocytes and enable them to respond to invading flagellated bacteria [29].…”

Section: Pattern Recognition Receptors Onmentioning

confidence: 99%

Innate Immunity in the Skin: How Keratinocytes Fight Against Pathogens

Pivarcsi¹,

Nagy²,

Kemény

2005

CIR

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The human skin is constantly exposed to a large number of external pathogens, due to the daily contact with the environment. The observation that extensive skin infections are relatively rare suggests the presence of an efficient host defense system at the skin surface. While the physical barrier function of the epidermis was formerly believed to play the major role in the protection against infections, the recent description of Toll-like receptors (TLRs) and antimicrobial peptides in the epidermis indicates that keratinocytes play an active role in innate immunity. To date TLR1, TLR2, TLR3, TLR4, TLR5, TLR6 and TLR9 have been described to be expressed in a constitutive or inducible manner in keratinocytes and to mediate the recognition of pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs results in the production of proinflammatory mediators such as cytokines, chemokines and antimicrobial peptides in keratinocytes. Recent findings indicate the importance of these peptides as effector molecules of innate immunity, but also as regulators of acquired immune responses, inflammation and wound repair. This review considers the current findings regarding TLR expression in the epidermis and the role these receptors might serve in host defense. Finally, the clinical relevance of the functions of keratinocytes in the innate immunity will be discussed in this review.

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“…is a Gram negative bacterium responsible for diseases such as food poisoning and typhoid, among others. However, in rare cases it is also known to cause rashes and ulcers particularly in immunocompromised patients [61,62]. Likewise, Staphylococcus aureus (S. Aureus) is a Gram positive bacterium that has the ability to cause food poisoning or skin infections based on the mode of transmission.…”

Section: Evaluation Of In Vitro Antibacterial and Antifungal Propertimentioning

confidence: 99%

Polyacrylamide-Metilcellulose Hydrogels Containing Aloe barbadensis Extract as Dressing for Treatment of Chronic Cutaneous Skin Lesions

et al. 2020

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Chronic wounds are severe breaks in the skin barrier that fail to heal in an acceptable time-frame, thus preventing the complete restoration of the tissue’s anatomical and functional integrity, increasing the likelihood of infections and apoptosis. Hydrogels are known as a drug delivery system and have the potential to cover wounds and burns on the skin. Aloe barbadensis contains over 75 different bioactive compounds which are responsible for its anti-inflammatory and antimicrobial properties. In this study, the polyacrylamide-co-methylcellulose hydrogel containing Aloe barbadensis were developed. The extract was prepared from lyophilized Aloe barbadensis, using methanolic extraction, characterized by high performance liquid chromatography and incorporated into the hydrogels. These Aloe barbadensis hydrogels were characterized by degree of swelling, Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermal profiling using thermogravimetric analysis. The minimum inhibitory concentration test was done on the Aloe barbadensis extract to evaluate its antibacterial and antifungal activity in vitro. The Aloe barbadensis hydrogels and were shown to swell to almost 2000% of their original sizes. The Fourier-transform infrared spectroscopy indicated the presence of bands characteristic of Aloe barbadensis and hydrogel polymers. The basic hydrogel showed greater thermal stability than the hydrogels with Aloe barbadensis. The minimum inhibitory concentration showed inhibition of the growth of S. aureus and Salmonella spp. at specific concentrations. The hydrogel therefore presents itself as an excellent potential curative cover of cutaneous lesions.

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Cutaneous infection caused by Salmonella typhi

Cited by 24 publications

References 13 publications

Mucocutaneous manifestations of dengue fever

Mucocutaneous manifestations of dengue fever

Innate Immunity in the Skin: How Keratinocytes Fight Against Pathogens

Polyacrylamide-Metilcellulose Hydrogels Containing Aloe barbadensis Extract as Dressing for Treatment of Chronic Cutaneous Skin Lesions

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