Cutaneous infection caused by Aspergillus terreus

Özer, Burçin; Kalacı, Aydıner; Duran, Nizami; Doğramacı, Yunus; Yanat, Ahmet Nedim

doi:10.1099/jmm.0.007799-0

Cited by 26 publications

(22 citation statements)

References 17 publications

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“…Nodules and pustular lesions although rare might also occur. [135] Our patient presented with nodules, which ulcerated after attempted incision and drainage in a referral clinic. There have been cases reported in the axillae and perineum of neonates, and in these patients the lesions typically originate as erythematous patches or Plaque that develop into pustules and eventually ulcerate to form necrotic eschars.…”

Section: Discussionmentioning

confidence: 98%

Primary cutaneous aspergillosis in an immunocompetent patient

Tahir

Garbati

Nggada

et al. 2011

J Surg Tech Case Report

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We present a 32-year-old woman with primary cutaneous aspergillosis and an apparently normal immune status. She is a dietitian who carried out research on Aspergillus contamination of palm oil over a six-month period, during which she apparently shaved her axillae and perineum using a safety razor blade. She presented with nodular lesions, which became extensive ulcers after an attempt at incision and drainage. Diagnosis was based on culture and histology. The patient was treated with itraconazole 200 mg twice a day, with surgical excision and a rhomboid flap cover of the axillae. She has remained disease-free five years after discharge. This highlights the likely benefits of a combination of surgical excision and drug therapy, in achieving a cure in this patient.

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Section: Discussionmentioning

confidence: 98%

Primary cutaneous aspergillosis in an immunocompetent patient

Tahir

Garbati

Nggada

et al. 2011

J Surg Tech Case Report

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“…Of the over 30 species of Aspergillus that have been associated with human infection, four were reported to cause eumycetoma, i.e. A. flavus , A. fumigatus , A. nidulans and A. terreus …”

Section: Introductionmentioning

confidence: 99%

Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry

Ahmed

Abbas

Jouvion

et al. 2015

Mycoses

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Chronic subcutaneous infections caused by Aspergillus species are considered to be extremely rare. Because these fungi are among the most common laboratory contaminants, their role as eumycetoma causative agents is difficult to ascertain. Here, we report the first case of A. flavus eumycetoma confirmed by isolation, molecular identification and immunohistochemical analysis. Patient was a 55-year-old male from Sudan suffering from eumycetoma on his left foot for a period of 17 years. He developed swelling, sinuses and white grain discharge was observed. He has been operated nine times and was treated with several regimens of ketoconazole and itraconazole without improvement. Initial diagnosis based on histology and radiology was Scedosporium eumycetoma. However, examination of the biopsy revealed A. flavus, which was identified by molecular analysis and MALDI-TOF MS. Immunohistochemistry using antibody directed against Aspergillus species was positive. Because of the earlier treatment failures with ketoconazole and itraconazole, therapy with voriconazole was initiated. However, in vitro susceptibility testing yielded a lower Minimum Inhibitory Concentration (MIC) value for itraconazole (0.25 μg ml(-1) ) than for voriconazole (1 μg ml(-1) ). Based on the presented results, A. flavus can be considered as one of the agents of white-grain eumycetoma.

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“…Others, such as A. terreus (subgenus Terrei, section Terrei) and A. versicolor (subgenus Nidulantes, section Nidulantes), are occasionally isolated from clinical specimens (3,29). The disease conditions, ranging from localized skin infection, nail infection, ocular infection, and pulmonary disorder to invasive systemic Aspergillus infection causing diskospondylitis, osteomyelitis, and pyelonephritis, are collectively referred to as "aspergillosis," an umbrella term coined by Hinson, Moon, and Plummer in 1952 (7,30,31,38,42).…”

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confidence: 99%

Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

et al. 2012

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Disseminated aspergillosis in dogs has been associated with Aspergillus terreus or A. deflectus infection. We report a case of disseminated A. versicolor infection presenting as diskospondylitis, osteomyelitis, and pyelonephritis. The diagnosis was made based on clinical, radiographic, and pathological findings. The etiologic agent was identified by fungal culture and internal transcribed spacer (ITS) ribosomal DNA (rDNA) sequencing. This is the first description of canine aspergillosis caused by A. versicolor. CASE REPORTA 31-kg, 2.5-year-old male castrated German shepherd dog was examined at the Texas A&M University Veterinary Medicine Teaching Hospital because of nonambulatory paraparesis, weight loss, and hyporexia for 3 months. At admission, the dog had a body temperature of 104.6°F, heart rate of 160 beats/min, respiratory rate of 80 breaths/min, and blood pressure of 173/99 mm Hg. Neurological examination revealed a hyperreflexive patellar reflex bilaterally. Motor function was absent in the right pelvic limb and questionable in the left. The patient had marked generalized muscle atrophy. A lateral radiograph of the cranial thorax revealed lysis and shortening of the first four sternebrae (Fig. 1A). The second and third sternebrae were most severely affected and had irregular margins with loss of their end plates. Lateral radiographs of the thoracic vertebral column showed lysis and shortening of the 9th (T9) and 10th (T10) thoracic vertebrae with loss of the end plates and spondylosis deformans ventrally (Fig. 1B). Narrowing of the intervertebral space, end plate sclerosis, and ventral spondylosis derformans were also found between the seventh and eighth thoracic vertebrae. The clinical diagnoses were diskospondylitis involving T9-T10, osteomyelitis of the sternum and left humerus, and T3-L3 myelopathy resulting in nonambulatory paraparesis. Suspected causes included disseminated aspergillosis, blastomycosis, coccidioidomycosis, bacterial infection, and neoplasia. Due to the poor prognosis, the dog was subsequently euthanized and a complete necropsy was performed.The major skeletal changes found at postmortem examination included marked bony proliferation of the cranial end of the sternum, extending from the first to the fourth sternebrae, with loss of the joint space between the second and third sternebrae ( Fig. 2A). A soft gray area of necrotizing osteomyelitis was in the center of the collapsed and fused sternebrae. In the thoracic vertebral column, there was loss of the intervertebral disk at T9-T10 with lysis of the associated vertebral end plates (Fig. 2B). The latter changes resulted in joint instability, overriding of the vertebral bodies, and spinal cord compression that was exacerbated with ventroflexion of the vertebral column. In the kidneys, there was dark red to purple mottling of the cortical region with dozens of white to tan areas throughout the cortex and medulla (Fig. 2C). The renal crests were ulcerated, and the pelvises were dilated and contained a small amount of cloudy fluid with ...

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Cutaneous infection caused by Aspergillus terreus

Cited by 26 publications

References 17 publications

Primary cutaneous aspergillosis in an immunocompetent patient

Primary cutaneous aspergillosis in an immunocompetent patient

Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry

Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

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