Cutaneous infection by Cryptococcus laurentii

Kamalam, A.; Yesudian, Patrick; Thambiah, A. S.

doi:10.1111/j.1365-2133.1977.tb15070.x

Cited by 43 publications

(24 citation statements)

References 2 publications

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“…Non-neoformans cryptococci have been most frequently isolated from the blood (11 cases), 9,[11][12][13][21][22][24][25] cerebrospinal fluid (5 cases), [7][8]13,15,27 and the lung (4 cases); 6,10,17,26 other sites include peritoneal fluid, [18][19] skin, 14,16 and the eye 20,23 ( Table 1). The most common isolates identified are C laurentii 14,[16][17][18][19][20][21][22][23][24][25] and C albidus 6-14 that account for 54% and 35% of reported infections, respectively.…”

Section: L I N I C a L M A N I F E S T A T I O N S O F I N F E C T mentioning

confidence: 99%

“…The most common isolates identified are C laurentii 14,[16][17][18][19][20][21][22][23][24][25] and C albidus 6-14 that account for 54% and 35% of reported infections, respectively. Other nonneoformans cryptococci reported to cause human disease are C curvatus, 15 C luteolus, 26 and most recently C uniguttulatus.…”

Section: L I N I C a L M A N I F E S T A T I O N S O F I N F E C T mentioning

confidence: 99%

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Infections due to non-neoformans cryptococcal species

McCurdy

Morrow

2003

Compr Ther

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Section: L I N I C a L M A N I F E S T A T I O N S O F I N F E C T mentioning

confidence: 99%

Section: L I N I C a L M A N I F E S T A T I O N S O F I N F E C T mentioning

confidence: 99%

Infections due to non-neoformans cryptococcal species

McCurdy

Morrow

2003

Compr Ther

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“…Among the infective species, three are considered human pathogens, C. albidus, C. laurentii, and C. uniguttulatus (Johnson et al 1998, McCurdy & Morrow 2001. Variable clinical manifestations are reported, such as instances of cutaneous infections (Kamalam et al 1977, Johnson et al 1998), ventriculitis (McCurdy & Morrow 2001, meningitis (Kordossis et al 1998), fungemia (Loison et al 1996, Johnson et al 1998, Kordossis et al 1998, Kunova & Krcmery 1999, pneumonia and pulmonary abscesses (Johnson et al 1998).…”

mentioning

confidence: 99%

In vitro susceptibility to antifungal agents of environmental Cryptococcus spp. isolated in the city of Ribeirão Preto, São Paulo, Brazil

Pedroso

Ferreira

Candido

2006

Mem. Inst. Oswaldo Cruz

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Infections by Cryptococcus strains other than C. neoformans have been detected in immunocompromised patients. Of these strains, three are considered human pathogens: C. albidus, C. laurenttii, and C. uniguttulatus. This study deals with the in vitro susceptibility of Cryptococcus to drugs such as amphotericin B, itraconazole, fluconazole, and 5-fluorocytosine. Environmental Cryptococcus isolates (50) distributed as follows: C. neoformans var. neoformans (16), C. albidus (17), C. laurentii (14), and C. uniguttulatus (3) were evaluated by the micro and macrodilution techniques, according to EUCAST and NCCLS recommendations, respectively. Considering both methodologies the respective minimal inhibitory concentrations (MIC) were 0.125 and 2 µg/ml for amphotericin B, 0.06 and 8 µg/ml for itraconazole, and 0.5 and more than 64 µg/ml for fluconazole and 5-fluorocytosine. Agreement percentages for the two methodologies were 100% for amphotericin B and fluconazole for all the strains tested. For itraconazole, the agreement percentage was 81.3% in the C. neoformans strain and 100% for all the others. All species had a agreement percentage of 94.1 to 100% when susceptibility to 5-fluorocytosine was tested. It is concluded that environmental isolates of C. neoformans var. neoformans, C. albidus, C. laurentii, and C. uniguttulatus may show high MICs against certain drugs, suggesting in vitro primary resistance to the antifungals tested

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“…have also been associated with opportunistic infections (Kamalam et al, 1977;Velez et al, 1996;Johnson et al, 1998;Kordossis et al, 1998;Ritterband et al, 1998;McCurdy and Morrow, 2001).…”

Section: Cryptococcus Uniguttulatus and Cryptococcus Laurentii)mentioning

confidence: 99%

A new cost-effective staining method for rapid identification of Cryptococcus

Wan¹,

Wang²,

Zhao³

et al. 2011

Afr. J. Microbiol. Res.

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Cryptococcosis is a life-threatening fungal disease that usually presents as an opportunist infection in immunocompromised hosts, and Cryptococcus neoformans is the major opportunistic pathogen of cryptococcosis. Rapid diagnosis of C. neoformans and other opportunistic Cryptococcus pathogens is required to meet the clinical need for immediate treatment. Historically, negative staining with India ink has been used to identify Cryptococcus. Another staining method utilizes Alcian blue, a dye that reacts selectively with C. neoformans, but not other Cryptococcus species. To overcome these limitations, we developed a new staining method for rapid identification of Cryptococcus using a novel, patent pending staining reagent for clinical laboratory diagnosis. Cryptococci stained with this new reagent can be conveniently counted directly via bench-top light microscopy. We also compared our novel stain with India ink and Alcian blue. Our results demonstrated that the new staining technique was superior to India ink stain for the rapid identification of Cryptococcus in clinical (and clinically mimicking) samples. Our stable and cost-effective staining reagent specifically stained Cryptococcus, highlighting its clinical applicability, particularly in developing countries due to its low cost.

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Cutaneous infection by Cryptococcus laurentii

Cited by 43 publications

References 2 publications

Infections due to non-neoformans cryptococcal species

Infections due to non-neoformans cryptococcal species

In vitro susceptibility to antifungal agents of environmental Cryptococcus spp. isolated in the city of Ribeirão Preto, São Paulo, Brazil

A new cost-effective staining method for rapid identification of Cryptococcus

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