Cutaneous immunohistochemical expression of interleukin-23 receptor (IL-23R) in psoriasis and psoriatic arthritis patients: Relation to musculoskeletal ultrasound findings

Structural study and expression of the androgen receptors during the reproductive cycle in the Harderian gland of the male Meriones libycus

“…As expected, we have observed, in the HG of the male of M. libycus, an increase in the intensity of the androgen receptors during the breeding period (February to July) compared with the resting period (September to January). The immunohistochemical expression with the androgen receptors in the autumn revealed high immunoexpression, while in winter there was a moderate immunoreaction; but during both spring and summer, a negative immune expression was evidenced [29]. This simulates the observation in the male rat [25], in both sexes of the golden hamster [26], and in guinea-pigs, mice, ducks, chickens, marine turtles, and lizards [28].…”

“…Further, we have examined the distribution of the androgen receptors in the gland cells. The androgen receptors are cytoplasmic in prismatic cells (types I and III) in both periods (breeding and resting), similar observations have been made in the HG of the male rabbit [29]. Other authors observed in the HG of rats that most type-I and II glandular cells displayed strong nuclear AR immunoreactivity, and that the intensity of the receptors' reactivity was similar in type-I and II glandular cells [31].…”

“…Our morphometric study shows that the Harderian epithelium increases in height during the reproductive period; this would be related to the secretory activity of the cells. The same observations were made in rabbit during the autumn [29]; in the green frog Rana esculenta, the cell height and secretory activity changed with the season and might be controlled by hormonal and environmental stimuli [30].…”

The Combination of IL-6, PLR and Nail Psoriasis: Screen for the Early Diagnosis of Psoriatic Arthritis

“…8 It was reported that IL-1, IL-6 and IL-8 seemed to be more closely associated with PsA, [9][10][11] and cutaneous expression of CXCL12 and IL-23R has been observed higher in PsA patients compared to psoriasis vulgaris patients. 12,13 Bos et al 14 also found that PsA patients had a marked increase in IL-2 production of T cells in the circulation compared with cutaneous psoriasis. Szentpetery et al 15 reported that reduction in Treg expression in the synovium of PsA but not in the psoriatic lesion, so IL-10 which was representative Treg cell may also be different in serum between PsA and cutaneous psoriasis.…”