Cutaneous immediate hypersensitivity in man: Effects of systemically administered adrenergic drugs

Kram, Jerrold; Bourne, Henry R.; Maibach, Howard I.; Melmon, Kenneth L.

doi:10.1016/0091-6749(75)90132-3

Cited by 18 publications

(6 citation statements)

References 9 publications

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“…Adrenaline diflers from otber ^2-agonists in that, wben given systemically in doses used clinically, it is capable of inhibiting both bistamine and antigen skin challenges. Compared with a previous study, wbere high doses of intravenous adrenaline were shown to have the same efl"ect [11], the present study used a small dose of subcutaneous adrenaline, which gives venous plasma levels in tbe physiological range [9]. Phenylephrine does not affect tbe response to intradermal skin tests [11] and this makes alpha stimulation alone an unlikely explanation of tbis action.…”

Section: Discussionmentioning

confidence: 83%

“…Compared with a previous study, wbere high doses of intravenous adrenaline were shown to have the same efl"ect [11], the present study used a small dose of subcutaneous adrenaline, which gives venous plasma levels in tbe physiological range [9]. Phenylephrine does not affect tbe response to intradermal skin tests [11] and this makes alpha stimulation alone an unlikely explanation of tbis action. Altbough oral ^82agonists are ineffective, high concentrations of locally injected ;82-agonists are effective inhibitors of bistamine and antigen cballenge; tbis is blocked by beta-receptor antagonists [6].…”

Section: Discussionmentioning

confidence: 83%

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Systemic adrenaline attenuates skin response to antigen and histamine

Warren

McCusker

Fuller

1988

Clin Experimental Allergy

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Summary Six atopic subjects received either adrenaline (0.3 ml of 1 mg/ml), subcutaneously over the deltoid muscle, or saline on 2 separate days. After 10 min, histamine and antigen were injected intradermally in the forearm. Adrenaline significantly inhibited the flare of histamine and both the flare and weal of antigen (P< 0.05). This anti‐allergic action of adrenaline occurred with a dose that we have previously shown produces plasma concentrations at the upper limit of the physiological range in resting normal subjects.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 83%

Systemic adrenaline attenuates skin response to antigen and histamine

Warren

McCusker

Fuller

1988

Clin Experimental Allergy

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“…2a, b). There was less inhibition 15 inin after allergen injection as coiripared with 5 inin after injection.…”

Section: Allergen and Histaminementioning

confidence: 79%

“…In a few individuals skin reactions to allergen were reduced by adding isoprenaline to the injection solution (2). Sublingual administration of isoprenaline antagonized cutaneous responses to allergen but not to histamine (231, while pretreatment with intravenously administered isoprenaline counteracted the responses to both agents (15). Finally a therapeutic regime of oral terbutaline or a single oral dose of 10mg fenoterol did not significantly alter skin responses to either allergen or histamine (4,…”

Section: Discussionmentioning

confidence: 99%

Effect of Terbutaline, a β₂‐adrenergic Receptor Stimulating Compound, on Cutaneous Responses to Histamine, Allergen, Compound 48/80, and Trypsin

Grönneberg¹,

Strandberg²,

Hägermark³

1979

Allergy

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The β‐adrenoceptor stimulating agent terbutaline (2 ng‐2 μg) injected intradermally in eight atopic subjects produced a dose‐dependent inhibition of the skin reactions induced by subsequently injected allergen. After injection of 0.5 μg terbutaline inhibition of the flare and weal responses was demonstrable throughout the observation period of 90 min. The flare response induced by histamine, the histamine liberator compound 48/80 and the proteolytic enzyme trypsin was not inhibited by terbutaline in the doses used, suggesting a selective action of terbutaline on the allergen‐induced response. The weal response elicited by histamine and compound 48/80 was slightly reduced by 2 ng terbutaline. It is suggested that pretreatment of me skin with terbutaline interferes with the ability of the cutaneous mast cells to respond to challenge with allergen and that terbutaline produces this effect in doses lower than those needed to counteract the permeability increasing effect of released mediator substances.

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“…It is worth noting that the use of sympathicomimetics in urticaria is not new. Indeed, it is well documented that epinephrine is efiicient in the treatment of acute urticaria (Kram et aL, 1975); its use in a loijg term therapy is evidently contra-indicated because of its side effects and the short duration of its action.…”

Section: Discussionmentioning

confidence: 99%

Treatment of chronic urticaria with a beta₂‐adrenergic stimulant

Kennès¹,

Maubeuge²,

Delespesse³

1977

Clin Experimental Allergy

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Summary Twenty‐four patients with chronic urticaria resistant to conventional therapy were treated orally with terbutaline, a specific β2 stimulant. This therapy was much more effective than antihistamines. At the dose of 1.25 mg three times a day, there were few side effects. The efficacy was independent of the IgE levels; it seemed greater in idiopathic cases than in cholinergic or pressure induced urticaria.

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Cutaneous immediate hypersensitivity in man: Effects of systemically administered adrenergic drugs

Cited by 18 publications

References 9 publications

Systemic adrenaline attenuates skin response to antigen and histamine

Systemic adrenaline attenuates skin response to antigen and histamine

Effect of Terbutaline, a β₂‐adrenergic Receptor Stimulating Compound, on Cutaneous Responses to Histamine, Allergen, Compound 48/80, and Trypsin

Treatment of chronic urticaria with a beta₂‐adrenergic stimulant

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Cutaneous immediate hypersensitivity in man: Effects of systemically administered adrenergic drugs

Cited by 18 publications

References 9 publications

Systemic adrenaline attenuates skin response to antigen and histamine

Systemic adrenaline attenuates skin response to antigen and histamine

Effect of Terbutaline, a β2‐adrenergic Receptor Stimulating Compound, on Cutaneous Responses to Histamine, Allergen, Compound 48/80, and Trypsin

Treatment of chronic urticaria with a beta2‐adrenergic stimulant

Contact Info

Product

Resources

About

Effect of Terbutaline, a β₂‐adrenergic Receptor Stimulating Compound, on Cutaneous Responses to Histamine, Allergen, Compound 48/80, and Trypsin

Treatment of chronic urticaria with a beta₂‐adrenergic stimulant