Cutaneous Penicillium marneffei infection in a patient with idiopathic <scp>CD</scp>4+ lymphocytopenia

Xia, Xiujiao; Shen, Hong; Xu, Ai-e

doi:10.1111/1346-8138.12899

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Their underlying conditions included idiopathic CD4+ thrombocytopenia, Job's syndrome, diabetes mellitus, splenectomy and colonic, breast and buccal cancers. 32 , 43 , 45 , 49 , 50 , 54 , 62 , 65 , 67 However, it is difficult to assess the exact role of these conditions in T. marneffei infection because of the limited number of cases. Interestingly, an increasing number of non-HIV-infected Asian patients with T. marneffei infection who were previously considered to have no underlying comorbidities were subsequently found to be positive for anti-IFN-γ autoantibodies.…”

Section: Specific Characteristics Of Non-aids Conditions Associated Wmentioning

confidence: 99%

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

Chan

Lau

Yuen

et al. 2016

Emerging Microbes & Infections

187

229

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Talaromyces (Penicillium) marneffei is an important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. The clinical significance of T. marneffei became evident when the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome epidemic arrived in Southeast Asia in 1988. Subsequently, a decline in the incidence of T. marneffei infection among HIV-infected patients was seen in regions with access to highly active antiretroviral therapy and other control measures for HIV. Since the 1990s, an increasing number of T. marneffei infections have been reported among non-HIV-infected patients with impaired cell-mediated immunity. Their comorbidities included primary adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies and secondary immunosuppressive conditions including other autoimmune diseases, solid organ and hematopoietic stem cell transplantations, T-lymphocyte-depleting immunsuppressive drugs and novel anti-cancer targeted therapies such as anti-CD20 monoclonal antibodies and kinase inhibitors. Moreover, improved immunological diagnostics identified more primary immunodeficiency syndromes associated with T. marneffei infection in children. The higher case-fatality rate of T. marneffei infection in non-HIV-infected than HIV-infected patients might be related to delayed diagnosis due to the lack of clinical suspicion. Correction of the underlying immune defects and early use of antifungals are important treatment strategies. Clinicians should be familiar with the changing epidemiology and clinical management of T. marneffei infection among non-HIV-infected patients.

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Section: Specific Characteristics Of Non-aids Conditions Associated Wmentioning

confidence: 99%

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

Chan

Lau

Yuen

et al. 2016

Emerging Microbes & Infections

187

229

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“…85 Skin abscesses have also been reported. 61,69 Neurological manifestations involve the meninges, the cerebrum, brainstem, cerebellum, cranial and peripheral nerves. The commonest reported neurological disorder was cryptococcosis, followed by progressive multifocal leukoencephalopathy (PMLE).…”

Section: Infectionsmentioning

confidence: 99%

Idiopathic CD4 Lymphocytopenia: Current Insights

Vijayakumar¹,

Viswanathan²,

Aghoram³

2020

ITT

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Idiopathic CD4 lymphocytopenia is a condition characterized by low CD4 counts. It is rare and most of the information about this illness comes from case reports. Presentation is usually in the 4th decade of life with opportunistic infections, autoimmune disease or neoplasia. The pathophysiology of this condition is not well understood. Management revolves around treatment of the presenting condition and close follow-up of these patients. This review presents a narrative summary of the current literature on idiopathic CD4 lymphocytopenia.

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“…Further reports of these associations are required to validate the consistency of the fungal susceptibility, along with mechanistic insights into the causal role of the lesioned gene in TDEF immunity. The TDEF and Cryptococcus infections have also been reported in clinical syndromes that were not genetically identified or investigated, including idiopathic CD4+ lymphocytopenia (ICL) [ 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ] and common variable immunodeficiency (CVID) [ 181 , 182 ]. In these cases, the absence of a molecular diagnosis precludes a refined understanding of immunopathogenesis.…”

Section: Methodsmentioning

confidence: 99%

Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases

Olbrich

Vinh

2023

JoF

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Inborn errors of immunity are a heterogeneous group of genetically determined disorders that compromise the immune system, predisposing patients to infections, autoinflammatory/autoimmunity syndromes, atopy/allergies, lymphoproliferative disorders, and/or malignancies. An emerging manifestation is susceptibility to fungal disease, caused by yeasts or moulds, in a superficial or invasive fashion. In this review, we describe recent advances in the field of inborn errors of immunity associated with increased susceptibility to fungal disease.

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Cutaneous Penicillium marneffei infection in a patient with idiopathic CD4⁺ lymphocytopenia

Abstract: We describe a case of cutaneous Penicillium marneffei infection in a non-HIV-infected male patient with idiopathic CD4(+) T lymphocytopenia (ICL). The cutaneous lesions were cured after the treatment of itraconazole combined with interleukin-2.

Cited by 5 publications

References 11 publications

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

<p>Idiopathic CD4 Lymphocytopenia: Current Insights</p>

Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases

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Cutaneous Penicillium marneffei infection in a patient with idiopathic CD4+ lymphocytopenia

Abstract: We describe a case of cutaneous Penicillium marneffei infection in a non-HIV-infected male patient with idiopathic CD4(+) T lymphocytopenia (ICL). The cutaneous lesions were cured after the treatment of itraconazole combined with interleukin-2.

Cited by 5 publications

References 11 publications

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients

<p>Idiopathic CD4 Lymphocytopenia: Current Insights</p>

Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases

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Product

Resources

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Cutaneous Penicillium marneffei infection in a patient with idiopathic CD4⁺ lymphocytopenia