Cutaneous Hypersensitivity Reactions to Autologous Extracts of Malignant Melanoma Cells

Fass, Leroy

doi:10.1016/s0140-6736(70)90467-8

Cited by 85 publications

(13 citation statements)

References 4 publications

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“…The finding of an inverse correlation between tumor size and cuta neous reactivity to the tumor appears to parallel experience in humans with Burkitt-lymphoma and malignant melanoma [5,6]. Skin reactivity to extracts of autologous tumor was lost in patients with extensive neoplasm.…”

Section: Discussionmentioning

confidence: 56%

Paw Test with Syngeneic Tumor Cells in Inbred Mice Bearing a Transplanted Sarcoma

Wells¹,

Cain²,

Bozalis³

et al. 1974

Int Arch Allergy Immunol

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Inbred C3H mice were inoculated subcutaneously with syngeneic, methylcholanthrene-induced sarcomas. During tumor growth, tumors were measured, and a cutaneous paw test carried out with viable tumor cells as antigen. In general, tumor paw tests were more reactive in mice with small tumors than in non-tumor-bearing control mice. When mice developed large tumors, their paw test reactivity decline, approaching that of unsensitized controls as tumors grew. The inverse correlation between tumor paw test reactivity and tumor volume is discussed. Side-to-side comparison of footpad reactivity indicated that the tumor paw test is highly reproducible. This model system in inbred mice appears useful for study of this and similar phenomena observed with some human neoplasms.

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Section: Discussionmentioning

confidence: 56%

Paw Test with Syngeneic Tumor Cells in Inbred Mice Bearing a Transplanted Sarcoma

Wells¹,

Cain²,

Bozalis³

et al. 1974

Int Arch Allergy Immunol

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“…' In a coded manner microscopic sections of 23 patients choroidal melanomas were ranked on the basis of prognostically useful histologic pathologic parameters. 2~a * 2 8 The rank order based on histologic parameters was compared with the rank order based on the diameter of induration with the soluble melanoma antigen. Using Spearman analysis there did not appear to be any correlation between histopathologic correlates of malignancy and the size of the skin test reaction with the soluble melanoma antigen in the 23 patients studied in this manner (Rs 0.07).…”

Section: Resultsmentioning

confidence: 99%

Skin tests with soluble melanoma antigens in patients with choroidal tumors

Char

Hollinshead

Herberman

1977

Cancer

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The cutaneous delayed hypersensitivity reactions with a soluble melanoma antigen in patients with choroidal mass lesions were studied. Ninety percent of patients with pathologically documented choroidal melanomas had positive melanoma antigen skin test responses. There did not appear to be any difference in the histologic appearance of the tumor nor in the disease status of those patients with positive versus those patients with negative skin test reactions. A 21% instance of false-positive responses with this partially purified soluble melanoma antigen in patients with simulating lesions was observed. The cause for this reactivity is unclear; however, from previous work tissue-associated antigens or fetal antigens are the most probable etiologies for the false-positive melanoma antigen skin tests observed. Further purification of the melanoma-associated antigen preparation may increase the specificity. The results of this study would mitigate against the use of this soluble melanoma antigen skin test in the primary evaluation of patients with pigmented choroidal mass lesions. Currently, the assay is being tested to ascertain its correlation with prognosis and as a means of monitoring immunotherapy.

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“…Skin test reactivity to standard antigens in patients with melanoma has been examined in a few studies. In two studies, cutaneous reactivity was found to be normal in these patients (Fass et al, 1970, Ziegler et al, 1969, whereas it was found to be diminished in two studies. In one of the latter studies, all the patients had received prior chemol:herapy or radiation (Seigler et al, 1972).…”

mentioning

confidence: 90%

Cellular immunity in patients with malignant melanoma and their household contacts

S̄pitler

Littooy

Sagebiel

1977

Cancer Immunol Immunother

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Cutaneous Hypersensitivity Reactions to Autologous Extracts of Malignant Melanoma Cells

Cited by 85 publications

References 4 publications

Paw Test with Syngeneic Tumor Cells in Inbred Mice Bearing a Transplanted Sarcoma

Paw Test with Syngeneic Tumor Cells in Inbred Mice Bearing a Transplanted Sarcoma

Skin tests with soluble melanoma antigens in patients with choroidal tumors

Cellular immunity in patients with malignant melanoma and their household contacts

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