Cutaneous Form of Periarteritis Nodosa— An Entity?

Fisher, I

doi:10.1001/archderm.1964.01590260018003

Cited by 33 publications

(5 citation statements)

References 14 publications

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“…On the other hand, other research workers (14)(15)(16)(17)(18)(19)(20) believe the disease to be only a stage or a early form of systemic PN, because there have been some cases (19)(20)(21)(22)(23)(24) that began with cutaneous manifestations and developed systemic PN at a later time. However, most of the previous reports (1-13) did not include longterm follow-up of the patients.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases

Chen

1989

The Journal of Dermatology

122

102

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Twenty cases diagnosed as cutaneous polyarteritis nodosa (CPN) and confirmed by skin biopsy over the last 17 years were reviewed in our department. Based upon their clinical features, laboratory findings, and long-term observation of the disease course, they were divided into three groups. 1) Group 1 comprised 16 cases which were classified as the mild cutaneous form. The disease was confined to the skin with occasional involvement of peripheral nerves and skeletal muscles of the affected extremity. They generally followed a benign course. 2) Group 2 comprised 2 cases classified as the severe form. Despite severe clinical manifestations and several abnormal laboratory findings, the disease was limited to the skin, muscles, and peripheral nerves without any visceral involvement over follow-up periods of 11 years and 5 years, respectively. 3) Group 3 comprised 2 cases of the progressive form; in these the disease had begun with a cutaneous lesion and progressed to the systemic form after 19 and 18 year periods of recurrent episodes of cutaneous lesions, respectively. One died of gastrointestinal bleeding. In group 3, serum antinuclear antibodies and rheumatoid factor were positive. The autoimmune mechanism seems to play a role in this group. It is clear from the results of this study that not all patients whose vasculitic lesions are apparently limited to the skin remain in a benign course. Long-term follow-up is essential.

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Section: Introductionmentioning

confidence: 99%

Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases

Chen

1989

The Journal of Dermatology

122

102

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“…(1977) observed eight cases of juvenile polyarteritis nodosa who presented with fever, malaise, calf pain and cutaneous nodulation, all of whom subsequently developed systemic involvement but nonetheless followed a relatively benign course. Fisher & Orkin (1964) preferred to view polyarteritis nodosa as a disease with a wide spectrum, rather than as a disease divisible into two distinct entities, and they suggested that the cutaneous involvement was inversely related to the degree of systemic involvement. Sack et al (1975) also observed that cutaneous involvement in polyarteritis nodosa was a pointer that the disease would follow a benign course.…”

Section: Discussionmentioning

confidence: 99%

The wide clinical spectrum of polyarteritis nodosa with cutaneous involvement*

Thomas

Black

1983

Clin Exp Dermatol

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Summary In order to assess the extent of systemic disease which may accompany polyarteritis nodosa when it involves the skin, fourteen cases of polyarteritis nodosa have been reviewed in whom there was histologically proven cutaneous involvement. It is concluded that a sub‐group of polyarteritis nodosa (in which the disease remains limited to the skin, muscles and peripheral nerves) can not necessarily be identified; however, predominant cutaneous involvement suggests a good prognosis.

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“…From cases reported in the literature, some patients may have a very protracted disease limited to the skin for a long time before involvement of other organ systems be¬ comes apparent. 19 In summary, we retrospectively reviewed the clini¬ cal course of nine patients who met the histopathologic criteria for the diagnosis of BCPAN and found seven of nine to have signs and symptoms that are indistinguish¬ able from those of classic PAN. Based on this analysis, we suggest that the two entities be combined into a more global picture of PAN, with some cases having marked cutaneous involvement and others having rela¬ tive sparing of the skin and more marked internal organ disease.…”

Section: Years)mentioning

confidence: 99%

Benign Cutaneous Polyarteritis Nodosa

Minkowitz¹

1991

Arch Dermatol

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Benign cutaneous polyarteritis nodosa has been described as having a benign course in contrast to that of systemic classic polyarteritis nodosa. We tested the hypothesis that this histologic distinction is false by reviewing nine consecutive cases with the histologic diagnosis of benign cutaneous polyarteritis nodosa. Our study revealed that on follow-up, seven (78%) of nine cases had evidence of involvement of at least one organ other than the skin, with the kidney being the organ most commonly involved. Four (44%) of nine patients had serologic evidence of hepatitis B infection, one had cryoglobulinemia, and one had polyclonal hypergammaglobulinemia associated with acquired immunodeficiency syndrome. We conclude that benign cutaneous polyarteritis nodosa is not necessarily benign and is closely related to systemic polyarteritis nodosa.

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Cutaneous Form of Periarteritis Nodosa— An Entity?

Cited by 33 publications

References 14 publications

Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases

Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases

The wide clinical spectrum of polyarteritis nodosa with cutaneous involvement*

Benign Cutaneous Polyarteritis Nodosa

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