“…Familial CCM cases also display cavernous malformations outside the brain, including in the bone, spine, adrenal glands, and skin (Campione et al, 2013 ; Haghighi et al, 2013 ; Manole et al, 2020 ; Sirvente et al, 2009 ; Strickland et al, 2017 ; Tandberg et al, 2020 ; Toll et al, 2009 ). Specifically, among familial cases with CCM1 / KRIT1 , cutaneous lesions reported include congenital hyperkeratotic capillary‐venous malformations (HCCVMs), punctate capillary malformations (PCMs), and deep blue nodules (DBNs) (Manole et al, 2020 ; Sirvente et al, 2009 ). Interestingly, similar appearing cutaneous lesions have been reported in another inherited vascular disease called capillary malformation‐arteriovenous malformation (CM‐AVM) caused by mutations in RASA1 (CM‐AVM1) and EPHB4 (CM‐AVM2) (Amyere et al, 2017 ; Eerola et al, 2003 ).…”