Cutaneous epithelioid malignant schwannoma: review of the literature and case report

Manganoni, Ausilia Maria; Farisoglio, Camillo; Lonati, Antonietta; Zorzi, Fausto; Tucci, G; Calzavara‐Pinton, Piergiacomo

doi:10.1016/j.bjps.2007.10.074

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…Earlier studies on cutaneous E‐MPNSTs, supported additionally by subsequent case reports, suggested that due to their superficial location, smaller size in comparison with their deeper counterparts and accessibility for complete surgical excision, cutaneous E‐MPNST generally follows a favourable clinical course than their counterparts at deeper locations . In the series by Laskin et al .…”

Section: Discussionmentioning

confidence: 85%

“…Using immunohistochemistry, E‐MPNST distinctively displays strong and diffuse nuclear S100 positivity, unlike classical MPNSTs, which typically only show focal S100 positivity in a limited number of cells in 50–80% of the tumours . In contrast to classical MPNST, occurrence from or within a pre‐existing benign peripheral nerve sheath tumour is uncommon in E‐MPNST, and the association with neurofibromatosis type 1 (von Recklinghausen's disease) is exceptional …”

Section: Introductionmentioning

confidence: 97%

“…Cutaneous E‐MPNST arises within the dermis and/or subcutis. The study by Laskin et al ., as well as a few additional case reports, suggested a more indolent clinical behaviour of cutaneous E‐MPNSTs due to their superficial location and thus probably earlier detection . However, recent analysis of 63 E‐MPNSTs at cutaneous, deep soft tissue and visceral sites failed to confirm any association between the anatomical site and depth of the tumour with the disease outcome …”

Section: Introductionmentioning

confidence: 99%

“…4 In contrast to classical MPNST, occurrence from or within a pre-existing benign peripheral nerve sheath tumour is uncommon in E-MPNST, and the association with neurofibromatosis type 1 (von Recklinghausen's disease) is exceptional. [6][7][8][9][10][11] E-MPNST can be subdivided further on the basis of its occurrence/localization into the superficial (cutaneous) and deep variants. 4,7 Cutaneous E-MPNST arises within the dermis and/or subcutis.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases

et al. 2015

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases

et al. 2015

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“…53,70,76,77 DISCUSSION DFSP, like other mesenchymal tumors, 78 does not have a particularly distinctive presentation and can simulate a benign or inflammatory lesion. DFSP was removed by surgical excision with a margin of 1.5 to 3 cm and including the underlying fascia or by the Mohs technique.…”

Section: Resultsmentioning

confidence: 98%

Dermatofibrosarcoma Protuberans in an Adolescent

Manganoni

Pavoni²,

Gualdi³

et al. 2013

Journal of Pediatric Hematology/Oncology

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Classically, dermatofibrosarcoma protuberans (DFSP) is a disease of adults. The world literature revision shows that several pediatric cases have been reported so far; this might suggest that the number of infants with the condition might be larger than that estimated previously. Here, we report the 183rd case of histologically confirmed DFSP in young age. A 14-year-old white male patient came under our care for a slowly growing, pale brownish lesion on the neck skin. A biopsy specimen showed a DFSP. Subsequently, a wide surgery excision with 3 cm of resection margins including the underlying fascia was performed. To date, the patient has been in follow-up for 6 years without evidence of recurrent disease. The clinical features and treatment of DFSP diagnosed in childhood and adolescence reported in the published literature are reviewed to provide new insights about this rare entity. The aim is to emphasize the importance of biopsy for histologic evaluation in the cases that show a persistent or a large cutaneous plaque or nodule without pathognomonic clinical features that permit a clinical diagnosis. An accurate knowledge of the disease is the prerequisite for a wider recognition and appropriate treatment.

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Immunohistology and Molecular Studies of Smooth Muscle and Neural Cutaneous Tumors

Ferringer

2016

Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

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Cutaneous epithelioid malignant schwannoma: review of the literature and case report

Cited by 12 publications

References 11 publications

Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases

Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases

Dermatofibrosarcoma Protuberans in an Adolescent

Immunohistology and Molecular Studies of Smooth Muscle and Neural Cutaneous Tumors

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