Cutaneous epithelioid hemangioendothelioma: A rare presentation

Kumar, Vineet; Kachhawa, Dilip; Rekha, S; Jain, V. K.

doi:10.4103/ijdvl.ijdvl_565_17

Cited by 2 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epithelioid hemangioendothelioma’s were first described by Deil and Liebow in 1975 in a case series of twenty patients with mostly soft tissue tumors and a few superficial tumors [ 37 , 38 , 39 ]. Weiss coined the term EHE when she published a case series in 1982 detailing forty-one cases, with the majority comprising soft tissue tumors and only a few cutaneous variants.…”

Section: Resultsmentioning

confidence: 99%

“…This extremely rare tumor is most common in people aged 30 to 50 and is uncommon in children [ 39 , 40 , 43 ]. Studies have indicated a slight female predominance [ 38 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…EHE has been reported to present as a solitary painful mass, verrucous mass, erythematous mass, multiple dome-shaped nodules and can be partially indurated or ulcerated. Due to its presentation, it can often be misdiagnosed as a scar or infection [ 39 , 40 , 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…EHE is thought to arise from preexisting vessels and is comprised of bland-appearing epithelioid endothelial cells with intracytoplasmic vacuoles and a characteristic myxohyaline stroma. Tumor cells demonstrate an infiltrative growth pattern without any defined lobular structure [ 39 , 41 ]. The epithelioid cells can be arranged in cords, single cells, or in small aggregates.…”

Section: Resultsmentioning

confidence: 99%

“…The nuclei are often small and vesicular and may or may not have small nucleoli present. Occasional tumor cells can show marked nuclear pleomorphism and hyperchromasia, but the mitotic rate is often low (less than three mitotic figures per 50 high power fields) [ 39 , 40 , 44 , 45 , 47 ]. The characteristic myxoid to hyaline stroma contains sulfated acid mucopolysaccharides.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Cutaneous Vascular Neoplasms of Uncertain Biological Behavior

McCollum

Al‐Rohil

2021

Biology

View full text Add to dashboard Cite

Neoplasms of uncertain biological behavior present physicians with a genuine conundrum in practice. Cutaneous vascular neoplasms within this category are exceedingly rare, possessing significant gaps and uncertainty in many facets of clinical practice. Firstly, lesions were selected for review based on their categorization as indeterminate behavior, indicating the potential for local recurrence and rarely metastasize. After identification of the target lesions, a comprehensive review of the literature using national databases produced several landmark studies and case series regarding these neoplasms. Limiting the review to only cutaneous limited tumors narrowed the pool of studies; however, quite a large sum of papers remained. Examination of each paper yielded beneficial results on diagnosing, effective treatments, follow-up findings, and prognosis for each indeterminate lesion discussed. Overall, the literature search combined the molecular, histologic, immunohistochemical, surgical strategies to develop an up-to-date and comprehensive framework to guide physicians when encountering such lesions. The tumors reviewed include: kaposiform hemangioendothelioma, endovascular papillary angioendothelioma, pseudomyogenic hemangioendothelioma, retiform hemangioendothelioma, epithelioid hemangioendothelioma, and composite hemangioendothelioma.

show abstract

Section: Resultsmentioning

confidence: 99%

“…This extremely rare tumor is most common in people aged 30 to 50 and is uncommon in children [ 39 , 40 , 43 ]. Studies have indicated a slight female predominance [ 38 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Cutaneous Vascular Neoplasms of Uncertain Biological Behavior

McCollum

Al‐Rohil

2021

Biology

View full text Add to dashboard Cite

show abstract

Rapidly Progressive and Debilitating Epithelioid Hemangioendothelioma: An Atypical Presentation of a Rare Malignant Cutaneous Vascular Neoplasm

Dash,

Behera,

Viswan

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor that comprises less than 1% of all vascular tumors. Cutaneous involvement in EHE can occur either by spreading from underlying bone or rarely could be limited to the skin and mostly presents as solitary well-circumscribed mass to an ill-defined infiltrative lesion. We present a case of rapidly progressive and debilitating EHE presenting multiple vascular papules and nodules. Histopathology showed an ill-circumscribed nodular proliferation of epithelioid and spindled cells in the dermis that extended into the subcutaneous tissue. The tumor cells had moderate eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli. In addition, they showed evidence of lumen formation and intracytoplasmic vacuoles. Brisk mitosis was noted. On immunohistochemistry, the cells were strongly positive for CD31, CD34, and ERG (ETS [erythroblast transformation-specific]-related gene). MIB-1 labeling index was more than 75% in the highest proliferating areas. A high degree of clinical suspicion and immunopathological examination is recommended for early diagnosis of this rare condition before it becomes function or life-threatening.

show abstract

Cutaneous epithelioid hemangioendothelioma: A rare presentation

Cited by 2 publications

References 7 publications

Cutaneous Vascular Neoplasms of Uncertain Biological Behavior

Cutaneous Vascular Neoplasms of Uncertain Biological Behavior

Rapidly Progressive and Debilitating Epithelioid Hemangioendothelioma: An Atypical Presentation of a Rare Malignant Cutaneous Vascular Neoplasm

Contact Info

Product

Resources

About