Cutaneous Effects and Sensitive Skin with Incontinence in the Aged

Sensitive Skin in the Genital Area

“…Overall histamine and histidine levels did differ significantly when individuals with perceived sensitive genital skin were compared to non-sensitive individuals (Figures 9A,B). Previously we reported that the ratio of histidine to histamine was significantly higher at the introitus and labia majora in individuals with perceived sensitive genital skin compared to individuals who were non-sensitive (60). However, after this publication appeared, corrected statistical analyses indicated that, although individuals with sensitive skin tended to have higher ratios of histidine to histamine, the differences were not significant (Figure 9C).…”

“…We conducted a study to evaluate potential differences in biomolecular and physical measures of the urogenital skin among women in different stages of life (59, 60). Subjects were categorized into three groups of 15 subjects each: the Pre-M group consisted of pre-menopausal women (mean age ± SD = 33.0 ± 6.4); the Post-M Non-HRT group consisted of post-menopausal women who were not receiving any hormone replacement therapy and who exhibited a vaginal atrophy score ≥6 and vaginal pH ≥5 (60.7 ± 3.6); and the Post-M HRT group consisted of post-menopausal women who had been taking some form of hormone replacement therapy for a minimum of 1 year (60.5 ± 3.6).…”

“…The pH was evaluated at 4 anatomic sites; vaginally and at the introitus, the labia minora, and the labia majora (60). Differences in pH were small (not reaching statistical significance), however within each test group, women who claimed sensitive genital skin tended to demonstrate a higher pH vaginally and at the introitus compared to those who did not claim sensitive skin (Figure 7).…”

“…The content of IL-1α, IL-1ra, and the ratio of IL-1ra/IL-1α were evaluated in the study groups (Figure 8) (60). In both post-menopausal study groups, the IL-1α content recovered from tape stripping at the introitus was significantly higher in women claiming sensitive genital skin (Post-M Non-HRT, p = 0.002; Post-M HRT, p = 0.004) (Figure 8A).…”