Cutaneous deposits

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00015-2

Cited by 16 publications

(33 citation statements)

References 899 publications

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“…Less commonly, it has been reported in squamous cell carcinoma, adnexal tumors such as cylindroma, pilomatrixoma and trichoblastoma, in seborrheic and actinic keratosis, porokeratosis and even Bowen's disease. 8 In this pilot study of 9 histologically proven cases of dermal amyloidosis, two thirds of the patients, i.e. 6/9 cases were reported as macular amyloidosis while one third of the patients i.e 3/9 cases were classified as lichen amyloidosis.…”

Section: Discussionmentioning

confidence: 87%

Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi

et al. 2017

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Section: Discussionmentioning

confidence: 87%

Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi

et al. 2017

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“…Secondary cutaneous amyloidosis is characterized by the presence of amyloid in the stroma of various cutaneous tumors such as basal cell carcinoma, squamous cell carcinoma, nevocellular nevi and a few adnexal tumours. 5 Secondary cutaneous amyloid deposits are also seen in seborrheic and actinic keratosis, Bowen's disease, porokeratosis, skin treated with UVA radiation after the ingestion of psoralens. 5 Lichen amyloidosis was first described by Gutmann in 1928.…”

Section: Resultsmentioning

confidence: 99%

“…5 Secondary cutaneous amyloid deposits are also seen in seborrheic and actinic keratosis, Bowen's disease, porokeratosis, skin treated with UVA radiation after the ingestion of psoralens. 5 Lichen amyloidosis was first described by Gutmann in 1928. 1 It is seen most frequently in South East Asia, China, and South America and is the commonest type of primary cutaneous amyloidosis.…”

Section: Resultsmentioning

confidence: 99%

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A clinicopathological study of primary localised cutaneous amyloidosis

et al. 2017

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Background: Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The term primary cutaneous amyloidosis (PLCA) usually includes macular amyloidosis (MA), lichen amyloidosis (LA) and nodular amyloidosis. Primary cutaneous amyloidosis is very common in Kerala probably due to socio-cultural practices. There has been no published data on PLCA from Kerala thus we undertook this study. The objectives of the study were to correlate clinical features of primary localized cutaneous amyloidosis with histopathologic findings; to evaluate the sensitivity of Congo red staining with polarized light in histopathologically proven primary localized cutaneous amyloidosis)Methods: We undertook an observational analysis for a period of 2 years from May 2012 to April 2014 in the Department of Dermatology, Amrita Institute, Cochin. All cases clinically diagnosed as cutaneous amylodosis were included in the study. After informed consent, skin biopsy was taken. The histopathologic sections were stained with Congo red and seen under polarized microscopy for apple green birefrengance.Results: A total of 70 patients were included in the study. Of the 70 cases, there were 20 males and 50 females. The most common clinical type was lichen amylodosis observed in 32 patients followed by macular amylodosis (28) and biphasic amyloidosis (10) cases. Histopathological compatibility was seen in 71% of MA and 89% cases of LA. Congored positivity was seen in 53.8%. Congored stain under immunofluorescence microscopy was done for 30 patients which gave a positivity of 85% which indicates that it is more sensitive that polarizing microscopy.Conclusions: Our study showed that the most common type is lichen amylodosis. Histopathology and congo red staining with polarized light is a valuable aid in diagnosis. Congo red stain under immunofluorescence microscopy has greater sensitivity and improves the diagnostic yield.

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“…With any fixation, the crystal deposits are surrounded by a granulomatous inflammation composed by macrophages and foreign body-type giant cells. 1 Weaver et al have recently introduced a simple nonstaining method to demonstrate urate crystals in formalin-fixed paraffin-embedded skin biopsies. The detection of urate crystals was achieved by the use of thicker (10 mm) unstained coverslipped sections.…”

Section: Introductionmentioning

confidence: 99%

The Nail Plate Biopsy May Pick up Gout Crystals and Other Crystals

Tirado-González

González‐Serva²

2011

The American Journal of Dermatopathology

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The rewarding use of nail clippings processed histologically for the diagnosis of some nail diseases is well established. A new application of the nail plate biopsies (NPBs) is the detection of crystals in the subungual horn. Besides other subungual crystals, urate crystals are heretofore undescribed. This presentation adds to the advantages of an NPB: the detection of some cases of gout on which urate crystals are extruded subclinically. While searching for fungi, 2 cases of gout were diagnosed histologically, aided by unstained thick sections. A history of gout was then confirmed. No tophi were noted in or near the nail field. Chasing for crystals opens the study of fluids that may exude or transude into nail structures, a kind of "nail window" into hematic or metabolic abnormalities. In sum, the abundance of cytologic and histologic findings in an NPB can expand the armamentarium of physicians to evaluate nail diseases and even systemic diseases in a noninvasive manner.

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Cutaneous deposits

Cited by 16 publications

References 899 publications

Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi

Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi

A clinicopathological study of primary localised cutaneous amyloidosis

The Nail Plate Biopsy May Pick up Gout Crystals and Other Crystals

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