Cutaneous copper and zinc losses in burns

Berger, Mette M.; Cavadini, C.; Bart, A.; Mansourian, Robert; Guinchard, Sylvie; Bartholdi, I.; Vandervale, A.; Krupp, Serge; Chioléro, René; Freeman, Joel B.; Dirren, Henri

doi:10.1016/0305-4179(92)90035-s

Cited by 125 publications

(62 citation statements)

References 24 publications

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“…In dietary copper deficiency, expression of the metalloenzyme does not decrease, but efficiency of the enzyme is reduced. This is consistent with the observation that dietary copper deficiency leads to slower skin wound healing (Berger et al, 1992). For example, lysyl oxidase's efficiency is known to be reduced as much as 50% in a copper deficient body, leading to osteoporosis, blood vessel damage, and connective tissue disorders.…”

Section: Introduction Copper In Humanssupporting

confidence: 90%

The complexation of aqueous metal ions relevant to biological applications. 2. Reactions of copper(II) citrate and copper(II) succinate with selected amino acids

Sobel

Haigney²,

Kim

et al. 2010

Chemical Speciation & Bioavailability

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Addition of amino acids, glycine, alanine, and serine, to poorly soluble copper(II) salts [copper(II) citrate and copper(II) succinate] all increase solubility of the copper(II) salts. Relative increases in solubility follow the polarity trend in the selected amino acids, with serine creating the greatest increase in solubility. Simultaneous equilibria calculations indicate the formation of mixed-ligand complexes in the copper(II) succinate -amino acid systems, the first time such mixed-ligand complexes have been observed. In contrast, mixed-ligand complexes are not predicted in the copper(II) citrate -amino acid systems. Potential bioavailability of copper(II) appears to be increased by the inclusion of amino acids in solution, roughly in parallel with the increase in solubility of the copper(II) salt. Therefore, measurement of the change in solubility caused by addition of amino acids to aqueous solution gives qualitative insight to the potential increase in bioavailability of the metal ion.

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Section: Introduction Copper In Humanssupporting

confidence: 90%

The complexation of aqueous metal ions relevant to biological applications. 2. Reactions of copper(II) citrate and copper(II) succinate with selected amino acids

Sobel

Haigney²,

Kim

et al. 2010

Chemical Speciation & Bioavailability

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show abstract

“…In addition, the number of PNLs was higher in SD + nicotine group than in SD + nicotine + Se group. Berger et al (1992) and Berger et al (1996) examined Se losses and balances in 10 patients with burns, and observed lower Se and plasma GSH-Px concentrations that could not be explained by measured losses. There are studies reporting increased GSH-Px activity in Se-supplemented L1210 cells cultured in fetal bovine serum (Lin et al, 1993;Geiger et al, 1991;Gül et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of Sleep Deprivation, Nicotine, and Selenium on Wound Healing in Rats

Gümüştekin

Seven

Karabulut

et al. 2004

International Journal of Neuroscience

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“…The latter was also highly significantly more effective than that of the BHT. It is worthy noted that ceruloplasmine is one of the acute phase transport proteins and that after intoxication; copper and zinc are depleted and tend to leave the body with urine, this depletion of copper may be a causative parameter for the decrease of ceruloplasmine [61].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Copper (I)-Nicotinate Complex Against Aflatoxicosis

R.¹

2013

TOTOXIJ

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Aflatoxicosis mostly leads to serious clinical signs of malnutrition, growth retardation, and impairment of utilization of nutrients, immunosupression, liver diseases and cancer. Detoxification or prevention of such toxicity is interesting to researchers in change field. In pursuit for an approach, the synthetic copper(I)-nicotinate complex has been evaluated against the traditional Butylated hydroxy toluene (BHT) for possible protective effects as a food additive in induced aflatoxicosed animals. Induction of toxicity in adult rats by AFB 1 60 µg/kg body weight divided on three times a week for consecutive five weeks resulted in marked hepatic necrosis, collagen fibers around portal tract and iron deposits as well as features of general cellular collapse and cirrhosis. The protective effects were tested on two animal groups by associate doses of BHT (0.05 mg / kg B.W.) in one group and copper (I) nicotinate complex (0.4 mg/kg B.W.) in the other. Results showed, in both groups, almost normal histological as well as biochemical markers especially those treated with the copper complex, which suggests that anti-inflammatory copper complex can be used as a protective agent against aflatoxicosis when used in doses resemble those used in pharmaceutical vitamin supplements.

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Cutaneous copper and zinc losses in burns

Cited by 125 publications

References 24 publications

The complexation of aqueous metal ions relevant to biological applications. 2. Reactions of copper(II) citrate and copper(II) succinate with selected amino acids

The complexation of aqueous metal ions relevant to biological applications. 2. Reactions of copper(II) citrate and copper(II) succinate with selected amino acids

Effects of Sleep Deprivation, Nicotine, and Selenium on Wound Healing in Rats

Protective Effects of Copper (I)-Nicotinate Complex Against Aflatoxicosis

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