Cutaneous Collagenous Vasculopathy: A Case Report and Review of the Literature

Monteagudo, Benigno; Pérez-Valcárcel, Javier; Ramírez-Santos, A.; Cabanillas, M.; Suárez-Amor, Óscar

doi:10.1016/s1578-2190(10)70668-5

Cited by 7 publications

(16 citation statements)

References 6 publications

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“…Cutaneous collagenous vasculopathy has almost exclusively been reported in middle‐aged and elderly men, although more recent cases occurred in women and a 16‐year‐old child, suggesting that a broader patient population may be affected. Patients with cutaneous collagenous vasculopathy present with blanchable, non‐urticating macules that usually occur symmetrically . Typically, the macules begin on the lower extremities and progress, spreading to the trunk and upper extremities and sparing the mucosal surfaces and nail beds .…”

Section: Discussionmentioning

confidence: 99%

“…Patients with cutaneous collagenous vasculopathy present with blanchable, non‐urticating macules that usually occur symmetrically . Typically, the macules begin on the lower extremities and progress, spreading to the trunk and upper extremities and sparing the mucosal surfaces and nail beds . The telangiectatic macules of the disorder tend to be asymptomatic but may rarely be associated with pruritus .…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the diagnostic microscopic findings are quite subtle. Patients present with telangiectatic macules, predominantly on the extremities, reminiscent of generalized essential telangiectasia . Cutaneous collagenous vasculopathy has been documented more commonly in men, although it may affect a wider spectrum of patients, as the disorder has been described in women and in at least one pediatric patient .…”

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Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy

et al. 2012

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Cutaneous collagenous vasculopathy is a rare microangiopathy of superficial dermal blood vessels. Patients present with telangiectatic macules, predominantly on the extremities. A skin biopsy specimen is necessary to distinguish cutaneous collagenous vasculopathy from generalized essential telangiectasia. Microscopically, cutaneous collagenous vasculopathy resembles the superficial telangiectasias of generalized essential telangiectasia but additionally shows hyaline material in thickened vessel walls. The amorphous pink material is periodic acid-Schiff-positive and resistant to diastase. We describe a series of four patients with cutaneous collagenous vasculopathy and highlight its clinical and histopathologic features.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy

et al. 2012

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“…Both are characterized by symmetrical and bilateral telangiectatic macules that initially appear on the legs, and gradually extend to the trunk and arms. They are asymptomatic and stable over time …”

Section: Discussionmentioning

confidence: 99%

Multiple telangiectasiae in a woman positive for hepatitis C virus

et al. 2014

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“…1 This entity is very rare with only 18 cases reported so far in the literature, [1][2][3][4][5][6][7][8][9][10][11] although it is likely to be underrecognized. 1 This entity is very rare with only 18 cases reported so far in the literature, [1][2][3][4][5][6][7][8][9][10][11] although it is likely to be underrecognized.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Collagenous Vasculopathy

Salama¹

2015

The American Journal of Dermatopathology

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Cutaneous collagenous vasculopathy (CCV) is a rare distinct idiopathic microangiopathy of the superficial cutaneous vasculature. Seven new cases are reported (6 females and 1 male) ranging in age from 42 to 85 years, with some showing unusual clinical and histopathological findings. All presented with macular telangiectases starting on the lower extremities and spreading progressively in 5 cases and were suspected to have generalized essential telangiectasia. Two cases had a history of over 20 years. One case had lesions in the abdominal striae, and 1 was markedly ecchymotic. All skin biopsies showed the characteristic features of CCV with dilatation and marked thickening of the walls of superficial dermal blood vessels displaying reduplication of the basement membrane on periodic acid-Schiff-diastase stain and deposition of hyaline collagenous material immunostaining as collagen type IV, and showing decreased or absent actin staining. However, the changes were subtle and only seen focally in some biopsies. Few lymphoid cells were present around occasional vessels. Electron microscopy showed increased basement membrane lamellae with marked deposition of normal and some abnormal collagen (Luse-like bodies) and focal endothelial damage, suggesting reparative perivascular fibrosis resulting from repeated endothelial injury. These cases (and all 18 previously reported ones) are of a wide age range and no gender predilection. This disorder is underdiagnosed, and it is likely that some cases clinically suspected to be generalized essential telangiectasia may actually represent CCV. Better recognition by dermatologists may lead to more biopsies from patients with generalized telangiectasia and a further understanding of the pathogenesis of CCV and its relationship to other cutaneous vascular disorders.

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Cutaneous Collagenous Vasculopathy: A Case Report and Review of the Literature

Cited by 7 publications

References 6 publications

Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy

Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy

Multiple telangiectasiae in a woman positive for hepatitis C virus

Cutaneous Collagenous Vasculopathy

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