Cutaneous Collagenous Vasculopathy: A Case Report and Review of the Literature

Castiñeiras-Mato, I.; Rodríguez-Lojo, Romina; Fernández-Díaz, M.L.; Nieves, Fernando Bal

doi:10.1016/j.adengl.2016.03.020

Cited by 6 publications

(10 citation statements)

References 10 publications

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“…32 CCV is primarily reported in the middle-aged and elderly but also younger individuals. 11,33,34 To date, in addition to our 25-year-old patient, cases of a 16-year-old and an 18-year-old have been reported. 11,35 The disease does not show a gender preference.…”

Section: Discussionmentioning

confidence: 81%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

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Cutaneous collagenous vasculopathy is a rare pauci‐inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine‐branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti‐endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti‐ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune‐ and non‐immune‐based endothelial cell injury in the pathogenesis of collagenous vasculopathy.

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Section: Discussionmentioning

confidence: 81%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

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“…The etiopathogenic mechanisms implicated in the development of these lesions remain to be elucidated. Similar to CCV, the possibility that a repeated microinjury affecting the vessel endothelium may lead to the characteristic perivascular fibrosis with production of abnormal collagen could be hypothesized . The observation of intravascular occlusive fibrin thrombi in some cases of CCV has led us to speculate a possible vascular occlusion as a possible underlying mechanism .…”

Section: Discussionmentioning

confidence: 99%

“…Similar to CCV, the possibility that a repeated microinjury affecting the vessel endothelium may lead to the characteristic perivascular fibrosis with production of abnormal collagen could be hypothesized. 7 The observation of intravascular occlusive fibrin thrombi in some cases of CCV has led us to speculate a possible vascular occlusion as a possible underlying mechanism. 8 However, the The clinical resemblance of the present case to Degos may suggest the involvement of similar-sized vessels, and a possible relationship between reported cases of isolated (benign) cutaneous Degos disease and this case cannot be completely ruled out.…”

Section: Introductionmentioning

confidence: 99%

Multiple progressive annular telangiectasias: A clinicopathological variant of cutaneous collagenous vasculopathy?

2017

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Telangiectasias are the clinical manifestation of diverse processes affecting blood vessels. Herein we report the case of a 60-year-old man presenting long-standing asymptomatic annular telangiectatic lesions with whitish centers. The histopathologic examination revealed thickened blood dermal vessel walls in the superficial dermis showing reduplication of the basement membrane resembling cutaneous collagenous vasculopathy (CCV). We suggest that this atypical clinicopathological presentation may represent either a localized annular variant of CCV or a previously unreported clinical form of multiple cutaneous telangiectasias.

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“…The disease is usually asymptomatic, but pruritus is rarely described. 8,11,12 Bleeding complications or bleeding diathesis associated with CCV have not been observed. Darkening of the lesions over time was described in several cases.…”

Section: Discussionmentioning

confidence: 99%

A case of cutaneous collagenous vasculopathy associated with multiple myeloma and with a pathogenic variant of the glucocerebrosidase gene

et al. 2022

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Cutaneous collagenous vasculopathy (CCV) is an extremely rare acquired microangiopathy of unknown etiology. The authors describe a case of a 68‐year‐old man, a carrier of a heterozygous pathogenic variant of the glucocerebrosidase (GBA) gene, who was diagnosed with CCV, revealing uncommon fibrinogen positivity in direct immunofluorescence. The patient was subsequently diagnosed with multiple myeloma. Treatment of the myeloma with combined chemotherapy including bortezomib, followed by autologous stem cell transplantation, led to significant reduction of cutaneous lesions. To the best of the authors' knowledge, this is the first published case of CCV in a carrier of a pathogenic variant of the GBA gene, associated with multiple myeloma and with significant regression of CCV after myeloma treatment. Direct immunofluorescence examination revealed an unusual fibrinogen deposition. Hypothetical causative role of bortezomib treatment was proposed regarding significant regression of CCV.

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Cutaneous Collagenous Vasculopathy: A Case Report and Review of the Literature

Cited by 6 publications

References 10 publications

Cutaneous collagenous vasculopathy: A report of three cases

Cutaneous collagenous vasculopathy: A report of three cases

Multiple progressive annular telangiectasias: A clinicopathological variant of cutaneous collagenous vasculopathy?

A case of cutaneous collagenous vasculopathy associated with multiple myeloma and with a pathogenic variant of the glucocerebrosidase gene

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