Cutaneous collagenous vasculopathy

Stavrou, Christiana; Uthayakumar, Aarthy; Calonje, Jaime Eduardo; Bunker, C.B.

doi:10.1136/bcr-2020-241434

Cited by 8 publications

(24 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Congo red stain would be negative, unlike in this case. 9 This case therefore also highlights the importance of obtaining biopsies that represent the dermis, especially when evaluating hyperpigmented lesions with a broad differential diagnosis. Although a shave biopsy was performed in this case, enough sample was obtained to evaluate and stain the dermis and its vessels, thus yielding this diagnosis.…”

Section: Discussionmentioning

confidence: 85%

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

Sadeghi,

Ziemer,

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 85%

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

Sadeghi,

Ziemer,

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

“…CCV is an asymptomatic, progressive microangiopathy of superficial cutaneous dermal vessels with thickened walls. 4,5 The differential diagnosis for this pattern of microvascular basement membrane zone thickening includes immune-based etiologies attributable to antiendothelial cell antibodies (AECAs), perhaps best exemplified by dermatomyositis; however, non-immune-based endothelial cell injury can result in similar microvascular changes, including those seen in cases of porphyria, pseudoporphyria, and diabetes mellitus. 6 It has been suggested that endothelial cell injury, regardless of the mechanism, leading to endothelial cell denudement is a stimulus to microvascular basement membrane zone thickening.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

View full text Add to dashboard Cite

Cutaneous collagenous vasculopathy is a rare pauci‐inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine‐branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti‐endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti‐ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune‐ and non‐immune‐based endothelial cell injury in the pathogenesis of collagenous vasculopathy.

show abstract

“…Given that the clinical presentation of CCV can be indistinguishable from other vascular disorders with cutaneous telangiectasias, especially generalized essential telangiectasia (GET), diagnosis requires biopsy to confirm the histopathology. [2][3] Distinctive histopathological findings of CCV include ectatic superficial blood vessels with thickened vessel walls containing type IV collagen, that stains periodic acid-Schiff (PAS) positive. [1][2] Fewer than fifty cases of CCV have been reported in the literature since it was first described by Salama and Rosenthal in…”

mentioning

confidence: 99%

Successful Treatment of Cutaneous Collagenous Vasculopathy with Pulsed Dye Laser: A Case Report

Ahearn

Tzur

Mahalingam³

et al. 2022

J of Skin

View full text Add to dashboard Cite

Cutaneous collagenous vasculopathy (CCV) is clinically characterized by symmetrical, progressive telangiectasias and an absence of systemic involvement. Histopathology is distinct and helps in differentiation from other vascular conditions that result in cutaneous telangiectasias. We present a case of biopsy-proven CCV that had localized clearance following biopsy and was successfully treated with pulsed dye laser. A healthy 36-year-old male presented with a 10-year history of progressive, blanching telangiectasias of the legs, thighs, and forearms. A punch biopsy of a representative patch on the patient’s right thigh demonstrated telangiectasias with thickened PAS-positive vessel walls and a sparse perivascular lymphoid infiltrate, features consistent with a diagnosis of CCV. While there was localized clearance at the biopsy site and adjacent skin, the patient opted for treatment with PDL for his lesions elsewhere. After testing various PDL settings, greatest cosmetic improvement and minimal PIH was achieved with a spot size of 7 mm, pulse duration of 3 milliseconds (ms) and a fluence of 8 J/cm2. Continued resolution of CCV was noted at 24 months. We present this case to underscore the potential efficacy of PDL in the treatment of CCV.

show abstract

Cutaneous collagenous vasculopathy

Cited by 8 publications

References 5 publications

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

Cutaneous collagenous vasculopathy: A report of three cases

Successful Treatment of Cutaneous Collagenous Vasculopathy with Pulsed Dye Laser: A Case Report

Contact Info

Product

Resources

About