Cutaneous changes of dermatomyositis in patients with normal muscle enzymes: Dermatomyositis sine myositis?

Stonecipher, Marcus R.; Jorizzo, Joseph L.; White, Wain L.; Walker, Francis O.; Prichard, Elizabeth

doi:10.1016/0190-9622(93)70136-h

Cited by 92 publications

(38 citation statements)

References 18 publications

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“…The speckled pattern was prevalent in all of the studies, with lower titers only in Stonecipher and coworkers' series. 17 We confirmed the speckled pattern of other reports and elevated titers as well. 14,16 No correlation was demonstrated between the presence of Raynaud phenomenon and positive antinuclear antibodies, but only a fortuitous association was made in 2 cases.…”

Section: Commentsupporting

confidence: 81%

“…1 In other series, 14,17 however, they were positive in almost all patients. The speckled pattern was prevalent in all of the studies, with lower titers only in Stonecipher and coworkers' series.…”

Section: Commentmentioning

confidence: 98%

“…9 Although other authors have encountered several diagnostic autoantibodies (anti-Jo-1, anti-Mi-2, anti-PML, and anti-Ku) in classic DM, 18 we failed to do so. First Braverman 19 and Bohan et al 20 suggested the possible association with malignancy in patients with ADM, and later Stonecipher et al 17 recommended examining patients with ADM, like those with classic DM. In fact, in the Chinese series, 7 60% of patients had malignancy.…”

Section: Commentmentioning

confidence: 99%

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Amyopathic Dermatomyositis

Caproni¹,

Cardinali²,

Parodi³

et al. 2002

Arch Dermatol

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Section: Commentsupporting

confidence: 81%

Section: Commentmentioning

confidence: 98%

Section: Commentmentioning

confidence: 99%

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Amyopathic Dermatomyositis

Caproni¹,

Cardinali²,

Parodi³

et al. 2002

Arch Dermatol

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“…Based on cutaneous findings and associations of DM with myopathy, neoplasms, or other connective tissue diseases, Stonecipher et al [5] and Sontheimer [1] proposed a classification system that subdivides adult-onset DM into two entities: classic DM (CDM) and clinically amyopathic DM (CADM).…”

Section: Introductionmentioning

confidence: 99%

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis

Jasso-Olivares

Tosti

Miteva

et al. 2017

Skin Appendage Disord

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Background: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described. Objective: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM. Methods: We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year. Results: Twenty-four out of 31 patients with DM had scalp involvement at clinical examination, with a prevalence of 77.4%. SDM was clinically characterized by erythema in all cases, scales in 20 (83.3%) patients, nonscarring alopecia in 21 (87.5%) patients, pruritus in 17 (70.8%) patients, and poikiloderma of the scalp in 16 (51.6%) patients. Twenty-eight patients were evaluated by trichoscopy. The most consistent finding was the presence of enlarged capillaries, found in 20 (71.4%) cases, followed by peripilar casts (57.1%) and tufting and interfollicular scales in 14 (50%) cases. Twenty-two patients also had positive nail fold capillaroscopic features similar to those observed by trichoscopy. Limitations: The simple size was limited. Conclusions: Scalp involvement and alopecia are common in patients with DM, and trichoscopy shows features similar to those found at capillaroscopy. Trichoscopy is a very important tool for diagnosis of scalp involvement in patients with DM.

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“…However, biopsy results have been reported in a series of 13 patients who did not have weakness or enzyme elevations [26]. Four of these 13 patients had abnormal biopsy results consistent with DM and eventually developed clinically apparent myopathy.…”

Section: Anatomic and Histologic Abnormalities In Skin And Musclementioning

confidence: 95%

Amyopathic dermatomyositis

Olsen¹,

Park²,

KingJr³

2001

Curr Rheumatol Rep

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Amyopathic dermatomyositis is a variant of dermatomyositis that is characterized by the typical skin rash but without the muscle abnormalities. It has been proposed that the amyopathic and myopathic forms of dermatomyositis exist on a continuum, a concept that is supported by family and genetic studies and the observation that a small proportion of amyopathic patients transform to a frankly myopathic state. The amyopathic state is defined by a lack of muscle weakness and through diagnostic tests, including serum muscle enzymes, electromyogram studies, and muscle biopsies, that are usually normal or show only minimal abnormalities. Despite the lack of weakness, many patients complain of debilitating fatigue. More sensitive measures of muscle function, such as P-31 magnetic resonance spectroscopy, suggest that muscle metabolism is abnormal in amyopathic patients. The amyopathic form is more commonly seen in adults than in children, although juvenile cases are reported. Some early series suggested no association with underlying malignancies, but recent reports indicate that malignancies occur. Determining whether a patient has amyopathic rather than myopathic disease may have prognostic implications.

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Cutaneous changes of dermatomyositis in patients with normal muscle enzymes: Dermatomyositis sine myositis?

Cited by 92 publications

References 18 publications

Amyopathic Dermatomyositis

Amyopathic Dermatomyositis

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis

Amyopathic dermatomyositis

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