1996
DOI: 10.1001/archderm.132.11.1395
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Cutaneous carcinoma during long-term hydroxyurea therapy: a report of 5 cases

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Cited by 18 publications
(16 citation statements)
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“…2 The association of HU treatment with secondary skin tumours in sun exposed areas has been widely documented in the literature and is a recognized long-term side-effect (Table 1). [1][2][3][4][5][6][7][8][9][10][11][12][13] To the best of our knowledge there is only one report in the literature documenting oral cancer (T 2 N 0 M 0 ) in an 83-year-old woman receiving long-term (15 years) HU for polycythemia vera, with synchronous multiple cutaneous and oral squamous cell carcinomas. 4 Although different, this report and ours suggest that at least in patients with no detectable risk factors, oral SCC secondary to HU occurs after more prolonged treatment and with higher cumulative doses of HU than happens with skin tumours.…”
Section: Reportmentioning
confidence: 99%
“…2 The association of HU treatment with secondary skin tumours in sun exposed areas has been widely documented in the literature and is a recognized long-term side-effect (Table 1). [1][2][3][4][5][6][7][8][9][10][11][12][13] To the best of our knowledge there is only one report in the literature documenting oral cancer (T 2 N 0 M 0 ) in an 83-year-old woman receiving long-term (15 years) HU for polycythemia vera, with synchronous multiple cutaneous and oral squamous cell carcinomas. 4 Although different, this report and ours suggest that at least in patients with no detectable risk factors, oral SCC secondary to HU occurs after more prolonged treatment and with higher cumulative doses of HU than happens with skin tumours.…”
Section: Reportmentioning
confidence: 99%
“…The association between skin tumours and hydroxyurea therapy in patients with myeloproliferative disorders was reported in a number of publications (Papi et al, 1993;Callot-Mellot et al, 1996;Young et al, 2000;Vassallo et al, 2001). However, metastatic skin tumours have not been reported in this patient population.…”
Section: Introductionmentioning
confidence: 73%
“…Ferner wurden das Auftreten einer Poikilodermie, eine erhöhte Photosensitivität und dermatomyositisartige Läsionen an Handrücken mit Papeln, die von den Gottron-Papeln nicht zu unterscheiden sind, beschrieben [23]. An sonnenexponierten Hautstellen [4] und selten an der Mundschleimhaut [7, 10] können spinozelluläre Karzinome entstehen. Zudem wurden palmoplantare Keratodermien, multiple Keratosen im Gesicht und das Auftreten von Alopezie beschrieben [17].…”
Section: Diskussionunclassified