Cutaneous carcinoma during long-term hydroxyurea therapy: a report of 5 cases

Callot-Mellot, C.

doi:10.1001/archderm.132.11.1395

Cited by 19 publications

(17 citation statements)

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“…2 The association of HU treatment with secondary skin tumours in sun exposed areas has been widely documented in the literature and is a recognized long-term side-effect (Table 1). [1][2][3][4][5][6][7][8][9][10][11][12][13] To the best of our knowledge there is only one report in the literature documenting oral cancer (T 2 N 0 M 0 ) in an 83-year-old woman receiving long-term (15 years) HU for polycythemia vera, with synchronous multiple cutaneous and oral squamous cell carcinomas. 4 Although different, this report and ours suggest that at least in patients with no detectable risk factors, oral SCC secondary to HU occurs after more prolonged treatment and with higher cumulative doses of HU than happens with skin tumours.…”

Section: Reportmentioning

confidence: 99%

Oral squamous cell carcinoma during long-term treatment with hydroxyurea

et al. 2004

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Hydroxyurea (HU) is commonly used for the treatment of chronic myelogenous leukaemia, polycythemia vera and essential thrombocythaemia. Patients receiving HU present a number of side-effects including skin/mucosa changes and tumours. Mucocutaneous abnormalities include xerosis, ichthyosiform lesions, dark brown pigmentation of skin folds and nails, malleolar ulcers, oral mucositis and oral ulcers. Cutaneous squamous/basal cell carcinomas have also often been reported following long-term administration of HU. HU-induced carcinogenesis is due to both the mutagenic potential of this agent and to an impairment of DNA repair mechanisms after damage by external factors such as ultraviolet radiation. Oral cancer following long-term treatment with HU has been reported only once, in a patient with concomitant multiple skin tumours. We present the unique case of a patient with polycythemia vera who developed oral cancer after 15 years of HU therapy.

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Section: Reportmentioning

confidence: 99%

Oral squamous cell carcinoma during long-term treatment with hydroxyurea

et al. 2004

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“…The association between skin tumours and hydroxyurea therapy in patients with myeloproliferative disorders was reported in a number of publications (Papi et al, 1993;Callot-Mellot et al, 1996;Young et al, 2000;Vassallo et al, 2001). However, metastatic skin tumours have not been reported in this patient population.…”

Section: Introductionmentioning

confidence: 73%

Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy

Pamuk¹,

Turgut²,

Vural³

et al. 2003

Clinical &Amp; Laboratory Haematology

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Hydroxyurea is a ribonucleotide diphosphate reductase inhibitor used in the treatment of patients with myeloproliferative disorders. Hydroxyurea has some dermatological side-effects. It has recently been recognized that hydroxyurea can induce squamous cell and basal cell carcinomas of skin. We present the case of an elderly man with chronic myeloid leukaemia who was treated with hydroxyurea for 4 years, with good control of his disease. However, in addition to the appearance of various skin lesions and cutaneous squamous cell carcinoma after 3 years of therapy, he was found to have a metastatic squamous cell carcinoma after 4 years. Hydroxyurea was discontinued, and he underwent surgery and radiotherapy. The patient subsequently died of ventricular fibrillation. We present this case to draw attention to the association between hydroxyurea and secondary skin cancers and to emphasize the need for dermatological examination before and during the course of hydroxyurea therapy.

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“…Ferner wurden das Auftreten einer Poikilodermie, eine erhöhte Photosensitivität und dermatomyositisartige Läsionen an Handrücken mit Papeln, die von den Gottron-Papeln nicht zu unterscheiden sind, beschrieben [23]. An sonnenexponierten Hautstellen [4] und selten an der Mundschleimhaut [7, 10] können spinozelluläre Karzinome entstehen. Zudem wurden palmoplantare Keratodermien, multiple Keratosen im Gesicht und das Auftreten von Alopezie beschrieben [17].…”

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Ulzerationen unter Therapie mit Hydroxyharnstoff

Boneberger

Rupec

Ruzicka³

2009

Hautarzt

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Hydroxyurea is frequently used for therapy of myeloproliferative disorders. One cutaneous side-effect is painful, therapy-resistant ulcers which have bizarre configurations and occur at atypical sites for venous ulcers. Improvement or healing often first occurs when hydroxyurea is discontinued. We report on one patient with essential thrombocythemia and two with polycythemia vera, who developed such ulcers during hydroxyurea therapy. In one case, the ulcers developed shortly after hydroxyurea was started. In addition we give a short overview of the current literature.

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Cutaneous carcinoma during long-term hydroxyurea therapy: a report of 5 cases

Cited by 19 publications

References 0 publications

Oral squamous cell carcinoma during long-term treatment with hydroxyurea

Oral squamous cell carcinoma during long-term treatment with hydroxyurea

Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy

Ulzerationen unter Therapie mit Hydroxyharnstoff

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