Cutaneous Burn Increases Apoptosis in the Gut Epithelium of Mice

The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?

“…It has been shown that a cutaneous burn induces small bowel epithelial cell apoptosis (31,32). In the same study, the authors showed that small bowel epithelial cell proliferation was not increased, leading to a loss of mucosal cells and hence mucosal mass (31,32). Similar findings were demonstrated in the heart (33,34).…”

The Hepatic Acute Phase Response to Thermal Injury

“…Despite the attempt to compensate increased apoptosis by increased hepatocyte proliferation, the liver cannot regain hepatic mass and protein concentration, as we found a significant decrease in hepatic protein concentration in burned rats. It has been shown that a cutaneous burn induces small bowel epithelial cell apoptosis (31,32). In the same study, the authors showed that small bowel epithelial cell proliferation was not increased, leading to a loss of mucosal cells and hence mucosal mass (31,32).…”

A Mathematical Model of the Human Small Intestine Following Acute Radiation and Burn Exposures

“…Proliferating crypt cells respond to radiation by immediately initiating a mitotic delay, and many proliferating cells undergo apoptosis (Lesher, 1967, Bond et al, 1965. Burn has an immediate effect on villus cells, promoting early cell death before migration is complete (Carter et al, 2014, Wolf et al, 1999. This response is fast and strong but is not observed after two days in mice (Wolf et al, 1999).…”

“…Burn has an immediate effect on villus cells, promoting early cell death before migration is complete (Carter et al, 2014, Wolf et al, 1999. This response is fast and strong but is not observed after two days in mice (Wolf et al, 1999). Crypt cells exhibit an additional response to burn which dampens proliferation.…”