Cutaneous breast cancer metastases successfully treated using an oxygen flow assisted administration of methotrexate (OFAMTX5%)

Abstract

Introduction: Cutaneous metastases of breast cancer (CMOBC) remain a therapeutic challenge. Recently, oxygen flow assisted topical administration of methotrexate 3% (OFAMTX5%) was proven an efficacious alternative treatment for extramammary Paget’s disease, an in situ mammary adenocarcinoma. Aim: To evaluate the efficacy and tolerance of OFAMTX5% for the treatment of CMOBC. Materials and methods: A patient with triple negative breast cancer presented with biopsy proven CMOBC. Two weekly sessions were given for 2 weeks with OFAMTX5% on a site of approximately 40 cm 2 . Skin biopsies were performed before and 2 months after procedure. Results: Tolerance was excellent with no pain sensations. Two months post procedure the treated area presented a postinflammatory hyperpigmentation. No residual metastases were evidenced on the control skin biopsy. Discussion: In selected cases of CMOBC OFAMTX5% can represent a non-painfull and efficacious treatment alternative. Larger series should evaluate the place of OFAMTX5% for the treatment of CMOBC.