Cutaneous blue naevi and related lesions

Mooi, Wolter J.; Krausz, Thomas

doi:10.1007/978-1-4899-6908-8_5

Cited by 1 publication

(3 citation statements)

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“…In five melanotic schwannomas, a biphasic staining pattern was present consisting of areas with pericellular deposition of basement membrane material next to areas with deposition around nests of tumor cells (nested/perilobular pattern). One lesion initially diagnosed elsewhere as a ‘peripherally located melanotic schwannoma’ was reclassified as a cellular blue nevus (case 19) [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The diagnosis of ‘cellular blue nevus’ was based on histological criteria described by Mooi [ 19 ]. This included a primary location of the lesion within the dermis with a biphasic architecture, especially at the base of the lesion, consisting of nodules and sheets of pale, oval melanocytes intermingled with pigmented dendritic melanocytes diffusely arranged in sclerotic stroma.…”

Section: Methodsmentioning

confidence: 99%

“… a Based on WHO criteria [ 24 ] b Based on criteria described by Mooi [ 19 , 20 ] c Based on criteria described by Brat et al [ 1 , 2 ] d Esp. Antoni A and B pattern, Verocay bodies and lipid-laden macrophages …”

Section: Methodsmentioning

confidence: 99%

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Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis

et al. 2010

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The histological differential diagnosis between melanotic schwannoma, primary leptomeningeal melanocytic lesions and cellular blue nevus can be challenging. Correct diagnosis of melanotic schwannoma is important to select patients who need clinical evaluation for possible association with Carney complex. Recently, we described the presence of activating codon 209 mutations in the GNAQ gene in primary leptomeningeal melanocytic lesions. Identical codon 209 mutations have been described in blue nevi. The aims of the present study were to (1) perform a histological review of a series of lesions (initially) diagnosed as melanotic schwannoma and analyze them for GNAQ mutations, and (2) test the diagnostic value of GNAQ mutational analysis in the differential diagnosis with leptomeningeal melanocytic lesions. We retrieved 25 cases that were initially diagnosed as melanotic schwannoma. All cases were reviewed using established criteria and analyzed for GNAQ codon 209 mutations. After review, nine cases were classified as melanotic schwannoma. GNAQ mutations were absent in these nine cases. The remaining cases were reclassified as conventional schwannoma (n = 9), melanocytoma (n = 4), blue nevus (n = 1) and lesions that could not be classified with certainty as melanotic schwannoma or melanocytoma (n = 2). GNAQ codon 209 mutations were present in 3/4 melanocytomas and the blue nevus. Including results from our previous study in leptomeningeal melanocytic lesions, GNAQ mutations were highly specific (100%) for leptomeningeal melanocytic lesions compared to melanotic schwannoma (sensitivity 43%). We conclude that a detailed analysis of morphology combined with GNAQ mutational analysis can aid in the differential diagnosis of melanotic schwannoma with leptomeningeal melanocytic lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%