Cutaneous bacterial colonization, modalities of chemotherapeutic infusion, and catheter-related bloodstream infection in totally implanted venous access devices

Laurenzi, L; Natoli, S; Benedetti, C.; Marcelli, Maria Elena; Tirelli, Walter; DiEmidio, L.; Arcuri, Edoardo

doi:10.1007/s00520-004-0607-4

Cited by 16 publications

(13 citation statements)

References 24 publications

(20 reference statements)

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“…Previous studies have shown that the time from port implantation to infection was highly variable (13,18). Laurenzi et al (2) documented a relationship between cutaneous colonisation and CRBI. In particular, Staphylococcus coagulase-negative and S. aureus reached maxima within several days following catheterisation and then decreased with time.…”

Section: Discussionmentioning

confidence: 99%

Symptoms and signs of port-related infections in oncology patients related to the offending pathogens

Liaw¹,

Chen²,

Chang³

et al. 2008

International Journal of Clinical Practice

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Summary Aim: There is limited information about symptoms and signs of port‐related infections linking to their offending pathogens. Methods: Oncology patients proven to have port‐related infections were retrospectively analysed. We divided them into two subgroups according to their symptoms and signs. Onset of fever and chills with or without hypotension following the port flush was classified as ‘port flush form infection’. Presence of local inflammatory signs, including erythema, warmth, tenderness and pus formation and systemic infection signs, including fever, chills with or without hypotension was classified as ‘local inflammatory form infection’. Results: There were 29 episodes of port‐related infection among 28 patients, with port flush form 22 episodes and local inflammatory form seven episodes. Of 22 episodes of port flush form infections, 20 (91%) were nosocomial glucose non‐fermenting gram‐negative bacilli, with Acinetobacter baumannii (11 episodes, 50%) and Enterobacter cloacae (four episodes, 18%) the most common. Polymicrobial infections occurred in four episodes (18%). Candida infection occurred in two episodes (9%). Of seven episodes of local inflammatory form infections, six (86%) were gram‐positive cocci, with Staphylococcus aureus (five episodes, 71%) the most common. The time from port implantation to its infection was 272 ± 255 days (30–993 days) for the port flush form infections and 82 ± 87 days (22–265 days) for the local inflammatory form infections. This difference was not significant difference (p = 0.068). Conclusions: The differences between infection of patients with port flush form and local inflammatory form in incidence and offending microorganism suggest that the aetiology of infection were different.

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Section: Discussionmentioning

confidence: 99%

Symptoms and signs of port-related infections in oncology patients related to the offending pathogens

Liaw¹,

Chen²,

Chang³

et al. 2008

International Journal of Clinical Practice

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“…Blood and cutaneous (n = 163) cultures were obtained. Four (2.5 %) positive blood cultures which yielded Staphylococcus simulans, Staphylococcus capitis, and S. aureus were obtained (n = 3 subjects) [52]. In contrast, those with negative blood cultures did not develop CRBI.…”

Section: Subcutaneous Portsmentioning

confidence: 98%

“…As foreign bodies and in the setting of a relative immunosuppresion, they can become a culprit for infections. Cutaneous flora can colonize the external catheter insertion site and travel along the exterior of the catheter (extraluminal) or directly along inside of the lumen (endoluminal), reaching the blood stream [52,53]. Extraluminal catheter-related bloodstream infection (CRBI) occurs primarily during this first week of insertion, whereas endoluminal CRBI tends to occur later and is attributable to catheter manipulation and use [52].…”

Section: Subcutaneous Portsmentioning

confidence: 99%

“…Extraluminal catheter-related bloodstream infection (CRBI) occurs primarily during this first week of insertion, whereas endoluminal CRBI tends to occur later and is attributable to catheter manipulation and use [52]. In a case series of 41 subjects with totally implanted venous access device, the incidence of positive skin and blood cultures was examined and related to development of CRBI [52]. Blood and cutaneous (n = 163) cultures were obtained.…”

Section: Subcutaneous Portsmentioning

confidence: 99%

“…Cutaneous flora can colonize the external catheter insertion site and travel along the exterior of the catheter (extraluminal) or directly along inside of the lumen (endoluminal), reaching the blood stream [52,53]. Extraluminal catheter-related bloodstream infection (CRBI) occurs primarily during this first week of insertion, whereas endoluminal CRBI tends to occur later and is attributable to catheter manipulation and use [52]. In a case series of 41 subjects with totally implanted venous access device, the incidence of positive skin and blood cultures was examined and related to development of CRBI [52].…”

Section: Subcutaneous Portsmentioning

confidence: 99%

See 2 more Smart Citations

Dermatologic Infections in Cancer Patients

Gandhi

Brieva²,

Lacouture

2014

Infectious Complications in Cancer Patients

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Dermatologic infections are among the most commonly experienced complications of cancer and anti-cancer therapy. Alterations in host immune function secondary to the underlying malignant process and/or its treatment have been linked to an increase in the risk of infections. The skin and its appendages (i.e., hair and nails) represent the first line of defense against infectious microorganism; its dysfunction as a physical barrier and an immunologic organ in cancer patients leads to an increased susceptibility to infectious organisms. Moreover, a cancer patient's vulnerable state facilitates dissemination of infections to other sites, secondarily involving the skin. This chapter delineates dermatologic infections that are unique to cancer patients as a result of their underlying malignancies and associated comorbidities as well as those resulting from antineoplastic therapies.

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