Cutaneous Anthrax

Sivakumar, Aravind; Kalimuthu, Abinaya; Malathi, M.

doi:10.1001/jamadermatol.2022.3216

Cited by 2 publications

(6 citation statements)

References 5 publications

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“…Cutaneous anthrax is a zoonotic infection caused by the bacteria Bacillus anthracis, which is responsible for over 95% of all anthrax cases [11]. In China, the growth of the livestock industry and the rise in cattle and sheep farming have led to an increase in localized outbreaks of cutaneous anthrax, causing panic among people and imposing a signi cant burden on socioeconomic development [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Edema is the primary clinical manifestation of cutaneous anthrax, and its duration determines the length of hospital stay [3,10,11,12]. In this study, 76 patients were evaluated, 53 of whom had moderate or greater perifocal edema, and 35 patients also experienced signi cant systemic toxic symptoms, such as fever.…”

Section: Discussionmentioning

confidence: 99%

“…Anthrax has different clinical presentations based on the route of infection and bacterial virulence. It can be classi ed into ve main clinical types: cutaneous anthrax, pulmonary anthrax, gastrointestinal anthrax, anthrax sepsis, and anthrax meningitis [8, 9,10,11]. Cutaneous anthrax is the most prevalent type, accounting for over 95% of all anthrax cases [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…It can be classi ed into ve main clinical types: cutaneous anthrax, pulmonary anthrax, gastrointestinal anthrax, anthrax sepsis, and anthrax meningitis [8, 9,10,11]. Cutaneous anthrax is the most prevalent type, accounting for over 95% of all anthrax cases [11,12]. The initial symptoms of cutaneous anthrax include rash, papules, and blisters of unknown origin on exposed areas like the hands, forearms, face, and neck.…”

Section: Introductionmentioning

confidence: 99%

“…In severe cases, extensive edema and necrosis may occur in the affected area, which, in the absence of appropriate treatment, can lead to secondary pulmonary anthrax, anthrax sepsis, anthrax meningitis, etc. The mortality rate for anthrax can be as high as 10-40%; however, pulmonary anthrax may have a mortality rate as high as 85% [9,10,11,12]. Therefore, early diagnosis and appropriate treatment of cutaneous anthrax are crucial for a favorable prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

luo,

Ma,

Zhou

et al. 2024

Preprint

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Background and ObAjectives: Anthrax is a global health concern, with cutaneous anthrax accounting for over 95% of cases and generally promising outcomes. Nonetheless, the absence of timely intervention can result in mortality rates of 10–40%. This research aims to explore the clinical presentations and phenotypic characteristics of cutaneous anthrax patients and evaluate the efficacy of various therapeutic approaches. Methods: A retrospective study was performed on 76 cutaneous anthrax patients identified at three hospitals from 2017 to 2022. Patients were categorized based on their hospital stay into two groups: those hospitalized for at least seven days and those for shorter durations. We assessed their clinical and phenotypic profiles, including symptoms, general health status, and laboratory findings, alongside treatment outcomes, focusing on hormone therapy and antibiotic regimens. Results: The study encompassed 76 diagnosed individuals, predominantly young adult males (78.9%). A significant gender disparity was noted. Hormonal treatment markedly improved edema regression in patients (P < 0.002), highlighting its therapeutic value. The impact of various antibiotic treatments on disease progression differed significantly based on hormone treatment status, with specific combinations showing more effectiveness in non-hormone-treated patients. Conclusions: The predominance of young male adults among cutaneous anthrax cases was observed, with early hormone treatment significantly reducing edema duration. In cases where hormone therapy is not utilized, employing piperacillin-tazobactam alone or in combination with quinolones effectively shortens the illness duration, suggesting a tailored approach to treatment can enhance patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

luo,

Ma,

Zhou

et al. 2024

Preprint

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A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

Liu,

Zheng,

et al. 2023

IDR

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Anthrax is caused by Bacillus anthracis . Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.

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Cutaneous Anthrax

Abstract: This case report describes a 1-year-old boy who was brought to the pediatric emergency department with complaints of a painless reddish skin lesion on the left buttock for 7 days.

Cited by 2 publications

References 5 publications

Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

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