Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile

Abstract

Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis. Radiotherapy was the most prescribed treatment, but many different combinations of surgery, chemotherapy and radiotherapy were observed. Mean disease-free and overall survival (15.4 and 23.7 respectively) were consistent with previous series, with local recurrence rate (2/9) lower than previously reported data. CD31 was positive in all patients. Vimentin, D2-40 and VEGFR-3 were expressed by the vast majority, Factor VIII by 3/7 and CD34 by about 1/3 of patients. Cytokeratin was negative in all patients. The patients with the most unfavourable course showed a strong expression of Ki-67, while those with the best outcome only had a slight positive Ki-67 staining. Larger studies regarding tumour cell expression of Ki-67 and other markers such as D2-40 will be helpful to evaluate a potential prognostic value of these stainings.

A 10‐year analysis of cutaneous mesenchymal tumors (sarcomas and related entities) in a skin cancer center

“…6 Most tumors arise in middle-aged adults with a 0.5% rate of metastases. 6,[19][20][21] We found eight patients in our files, which have been described in detail recently. 6 In more than 90% of cases, a unique translocation Figure 2 Advanced angiosarcoma with regional lymph node involvement involving chromosomes 17 and 22 has been detected, leading to a fusion product COL1A1-PDFGB, which results in upregulation of platelet-derived growth factor beta -a ligand for transmembrane receptor kinase.…”

Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma

“…[5][6][7] Patients' prognosis, however, remains poor with a 5-y survival of approximately 10% to 20% due to the eventual formation of distant metastases. [8][9][10] The development of more effective treatments is therefore required, and immunotherapy could be a therapeutic option. Fujii et al reported that antitumor immunity with CD8 C T cells in tumor-infiltrating lymphocytes (TILs) is important to prevent the progression of CAS.…”

Vascular structure absence under dermoscopy in two cases of angiosarcoma on the scalp

“…Cutaneous angiosarcoma (AS) is a rare malignant tumor of soft tissue and is known to have three clinical subtypes: classical AS (head and neck type), Stewart–Treves syndrome, and post‐radiation AS . Few dermoscopic features of AS have been reported and it has not yet been examined in detail.…”