Cutaneous and renal glomerular vasculopathy in a great dane resembling ‘Alabama rot’ of greyhounds

Rotermund, A.; Peters, Marion G.; Hewicker‐Trautwein, M.; Nolte, Ingo

doi:10.1136/vr.151.17.510

Cited by 18 publications

(21 citation statements)

References 6 publications

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“…HUS has previously been reported in five dogs ( Holloway and others 1993 , Chantrey and others 2002 , Dell'Orco and others 2005 ), three cats ( Aronson and Gregory 1999 ) and a number of other species ( Morris and others 1987 , Roby and others 1987 , Garcia and others 2002 , Dickinson and others 2008 ). CRGV has been almost exclusively reported in greyhounds ( Carpenter and others 1988 , Hendricks 2000 ), although there is one report of an affected Great Dane ( Rotermund and others 2002 ). In contrast, HUS in dogs has been reported in a variety of breeds: Yorkshire terrier, miniature poodle, Labrador retriever, German shepherd dog and boxer ( Holloway and others 1993 , Chantrey and others 2002 , Dell'Orco and others 2005 ).…”

Section: Discussionmentioning

confidence: 99%

“…E. coli shiga toxin has not been identified in dogs with HUS ( Holloway and others 1993 , Chantrey and others 2002 , Dell'Orco and others 2005 ) or CRGV ( Rotermund and others 2002 ). Shiga toxin has been identified in one horse ( Dickinson and others 2008 ) and two of three rabbits previously reported with HUS ( Garcia and others 2002 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is variably associated with clinically relevant acute kidney injury (AKI). CRGV has been reported in greyhounds in the USA ( Carpenter and others 1988 ), a Great Dane in Germany ( Rotermund and others 2002 ) and a greyhound in the UK ( Hendricks 2000 ).…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Holm

Hawkins²,

Robin

et al. 2015

Veterinary Record

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To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and renal thrombotic microangiopathy (TMA) was histopathologically confirmed. The medical records of dogs with skin lesions and AKI, with histopathologically confirmed renal TMA, were retrospectively reviewed. Thirty dogs from across the UK were identified with clinicopathological findings compatible with CRGV. These findings included the following: skin lesions, predominantly affecting the distal extremities; AKI; and variably, anaemia, thrombocytopaenia and hyperbilirubinaemia. Known causes of AKI were excluded. The major renal histopathogical finding was TMA. All thirty dogs died or were euthanised. Shiga toxin was not identified in the kidneys of affected dogs. Escherichia coli genes encoding shiga toxin were not identified in faeces from affected dogs. CRGV has previously been reported in greyhounds in the USA, a greyhound in the UK, without renal involvement, and a Great Dane in Germany. This is the first report of a series of non-greyhound dogs with CRGV and AKI in the UK. CRGV is a disease of unknown aetiology carrying a poor prognosis when azotaemia develops.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Holm

Hawkins²,

Robin

et al. 2015

Veterinary Record

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“…27 Unidentified genetic factors may also be involved, but this acute and potentially lethal syndrome has also been recognized in other breeds such as Great Danes. 28 The true etiology of this disease thus remains unproved.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Cutaneous Vasculitis in Small Animals

Innerå¹

2013

Veterinary Clinics of North America: Small Animal Practice

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Cutaneous vasculitis is an inflammatory process targeting blood vessels. Underlying factors include drugs, infectious diseases, adverse reactions to food, malignancies, and immune-mediated diseases. Vasculitis is a reaction pattern warranting a workup to identify triggers. Presenting symptoms include purpura, pitting edema, and skin ulcerations. Constitutional signs include fever, depression, and anorexia and seem to be present in the majority of patients. Once a diagnosis is confirmed, treatment and follow-up must be tailored to the individual. High-dose immunosuppressive medications are only recommended once infectious diseases capable of producing a similar constellation of clinical signs have been ruled out.

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“…This should allow comparison to the published cases of idiopathic CRGV (Carpenter and others 1988, Hertzke and others 1995, Cowan and others 1997, Rotermund and others 2002). …”

mentioning

confidence: 94%

Suspected idiopathic cutaneous and renal glomerular vasculopathy in dogs

Walker¹,

Holm²,

Hawkins³

et al. 2014

Veterinary Record

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Suspected idiopathic cutaneous and renal glomerular vasculopathy in dogs THERE has been some recent media interest in a small number of dogs with clinical signs and renal histopathological findings similar to those described in greyhounds with idiopathic cutaneous and renal glomerular vasculopathy (CRGV) (Carpenter and others 1988). The aetiology of the disease is unknown. Over the past 14 months we have become aware of 16 dogs in the UK that were suspected to be suffering from idiopathic CRGV. The majority of the reported cases were documented between December 2012 and March 2013. Most dogs had been walked in the New Forest before the development of clinical signs; however, cases were also identified from Cornwall, Dorset, Surrey, Worcestershire and County Durham. The skin lesions identified have generally had a similar appearance to those described previously in cases of idiopathic CRGV (Carpenter and others 1988, Rotermund and others 2002). The affected dogs went on to develop clinical signs of acute kidney injury over the subsequent two to seven days. We are currently preparing a paper including all of the case information, clinical pathology findings, light microscopy findings, electron microscopy findings and the results of further investigations, including an epidemiological study. This should allow comparison to the published cases of idiopathic CRGV (Carpenter and others 1988, Hertzke and others 1995, Cowan and others 1997, Rotermund and others 2002). This is a small number of dogs and it is important to highlight that most skin lesions will not be caused by this disease. It is also important to note that most dogs with acute kidney injury will have another underlying cause. We have been collating data on suspected cases and will continue to do so. We would be grateful if colleagues could contact us to make us aware of any historical or current case that has skin lesions of unknown cause and concurrent acute kidney injury in which another obvious cause has not been identified. We might be able to provide renal and dermal histopathology free of charge on postmortem samples from suspicious cases, but please contact us before sending tissues to confirm that the case qualifies for the study.

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Cutaneous and renal glomerular vasculopathy in a great dane resembling ‘Alabama rot’ of greyhounds

Cited by 18 publications

References 6 publications

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Cutaneous Vasculitis in Small Animals

Suspected idiopathic cutaneous and renal glomerular vasculopathy in dogs

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