Cutaneous allergy to human (recombinant DNA) insulin

Gonzalo, Montserrat; Argila, D. de; Revenga, F; García, J.; Díaz, José‐Luis; Morales, Francisco

doi:10.1111/j.1398-9995.1998.tb03786.x

Cited by 22 publications

(11 citation statements)

References 5 publications

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“…Bovine insulin, which differs from human insulin by three amino acids, is more allergenic than porcine insulin, which differs from human insulin at only one amino acid. Local insulin-allergic reactions are observed in perhaps 2±3% of patients treated with highly puri®ed pork or human insulin, but systemic reactions are very rare 2 . Such reactions can ®rst occur with the initiation of insulin therapy, or many years after initial insulin treatment [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Local insulin-allergic reactions are observed in perhaps 2±3% of patients treated with highly puri®ed pork or human insulin, but systemic reactions are very rare 2 . Such reactions can ®rst occur with the initiation of insulin therapy, or many years after initial insulin treatment [2,3]. Allergy is usually due to the insulin molecule itself.…”

Section: Discussionmentioning

confidence: 99%

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Generalised allergic reaction to human insulin

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Generalised allergic reaction to human insulin

et al. 2000

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“…IgE‐mediated symptoms occur immediately after insulin injection. Skin reactions vary from local erythema and swelling at the injection site to generalized reactions like urticaria and angioedema (9, 10). Interestingly, flare reactions can also be elicited at the former injection sites upon insulin injection (11).…”

Section: Clinical Presentationmentioning

confidence: 99%

Insulin allergy: clinical manifestations and management strategies

Heinzerling

Raile

Rochlitz

et al. 2008

Allergy

138

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Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is suspected upon noticing immediate symptoms following insulin injections. The immediate vital implications for the patient call for prompt diagnosis and management of insulin allergy. We review current knowledge and procedures based on four diabetic patients who presented in our clinic. Insulin allergy was suspected as they showed immediate symptoms after insulin injection (urticaria, rash, angioedema, hypotension, dyspnea). A detailed allergologic work‐up was performed and adequate therapy was initiated. In three of the four patients, a specific immunotherapy was started whereas in one patient a switch to oral antidiabetics was possible and consequently initiated. By standard prick testing and measurement of specific IgE antibodies, a type 1 IgE‐mediated allergy was confirmed. After initiation of insulin immunotherapy, the symptoms completely resolved in two out three of patients and significantly improved in the third patient. The fourth patient was successfully switched to oral antidiabetics. Insulin allergy is a rare but severe condition that calls for immediate allergological work‐up. It can be managed well in close cooperation between the diabetologist and the allergologist. Specific immunotherapy is efficient and should be considered.

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“…Allergic reactions during human recombinant (rDNA) insulin therapy have been reported in several cases [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The insulin preparation (IP) contains multiple potential allergens: insulin, carrier proteins, and additives [15].…”

Section: Introductionmentioning

confidence: 99%