Cutaneous Alerts in Systemic Malignancy: Part I

Yuste-Chaves, M.; Unamuno-Pérez, P. de

doi:10.1016/j.adengl.2012.03.027

Cited by 12 publications

(8 citation statements)

References 64 publications

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“…Cutaneous manifestations may be highly specific to the disease, occur primarily due to the malignancy and include cutaneous metastases and cutaneous markers of various tumor syndromes or are nonspecific and include paraneoplastic syndromes, cutaneous infections, pigmentary disturbances, etc. 3 Some changes are also due to the various treatment modalities employed; for example, alopecia, papulopustular rash, hand-foot syndrome, paronychia and mucositis are common skin reactions seen in patients undergoing chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Dermatological Manifestations in Cancer Patients: A Hospital Based Study

Thapa

2018

Nep. Med. Coll. J.

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Skin can show various manifestations in patients suffering with malignancy, which may be specific or non specific. In absence of any available literature on this issue, we conducted this study to know the dermatological conditions affecting Nepalese patients with malignancy. A total of 62 patients who were referred for dermatological consultation both from out-patient department and in-patient department of Nepal Cancer Hospital were included in this study. Data including demographic variables, type of malignancy, duration since diagnosis, chemotherapeutic agents administered and dermatological manifestation were recorded. The frequency of Dermatological manifestation in cancer patients was found to be 0.41%. There were 56% females and 44% males. Mean age of presentation was 44 years. These patients had primary malignancy as carcinoma breast in 31%, lung carcinoma 21%, carcinoma colon 16%, carcinoma rectum 8%, carcinoma pancreas 7% and 3% each had carcinoma prostate, carcinoma stomach, carcinoma ovary and oral carcinoma and Ewing sarcoma. The mean duration of presentation of primary carcinoma was 8 months. The most frequent dermatoses was eczema in 39%, followed by infection 25%, pruritus 14%, insect bite hypersensitivity 3.2%, disorder of pilosebaceous unit 3.2%, urticaria 3.2%, pigmentary changes 3.2%, nail involvement 3.2%, drug rash 2%, vesiculo-blistering disorder 2% and cutaneous metastasis in 2%. In absence of screening program, we found a very low frequency of cutaneous manifestation in patients with malignancy in our study. We recommend a prospective long term follow-up study with institution of screening and awareness program.

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Section: Discussionmentioning

confidence: 99%

Dermatological Manifestations in Cancer Patients: A Hospital Based Study

Thapa

2018

Nep. Med. Coll. J.

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“…Etiopathogenesis: PS are believed to be caused by the excessive production or depletion of bioactive substances, growth factors, hormones, or by antigen-antibody interactions with an aberrant host response to various types of cancer [ 2 ]. In case of ovarian teratoma, the hypothesis of an autoimmune pathophysiology [ 9 ] is supported by its composition of ectoderm; mesoderm and endoderm which could induce an autoimmune response [ 5 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Paraneoplastic syndromes are a heterogeneous collection of manifestations caused by underlying neoplasm [ 1 ]. It can proceed, occur with, or develop after a malignancy [ 2 ], affecting patients of all ages [ 3 ] and are often misdiagnosed [ 4 ]. Actually, major advances in the management include the discovery and improved characterization of these syndromes, detection of new anti-neuronal antibodies and the use of CT and PET scan to reveal the associated tumors at an early stage [ 5 ] in order to improve prognosis [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic syndromes revealing ovarian teratoma in young and menopausal women: report of two cases

Boujoual¹,

Hakimi²,

Kassidi³

et al. 2016

Pan Afr Med J

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Paraneoplastic syndromes are a heterogeneous group of clinical and biological manifestations caused by underling neoplasms. They can reveal ovarian teratoma which express neuroendocrine proteins, or contain mature or immature neural tissue inducing an autoimmune response. The etiological investigation is then crucial to early identification of the tumor in order to optimize the prognosis and to limit neurological sequelae. In case of ovarian teratoma, management is essentially based on surgical resection sometimes associated with immunotherapie. We report two new cases of ovarian teratoma revealed by paraneoplastic syndromes in young and menopausal woman.

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“…Although the cutaneous manifestations of internal malignancies are well known, no predictive skin manifestations have been determined till date [7,15,16]. Lung cancer has been the most common cancer worldwide since 1985, both in terms of incidence and mortality.…”

Section: Introductionmentioning

confidence: 99%