Cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia

Ding, Wen Yi; Lee, Chew Kek; Choon, Siew Eng

doi:10.1111/j.1365-4632.2010.04481.x

Cited by 96 publications

(119 citation statements)

References 20 publications

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“…Similar to our observation, several studies reported maculopapular rash as the most common cutaneous adverse drug reaction. [4][5][6] The time of onset of maculopapular eruption after the suspected medication intake ranged from 1 day to 7 days in our study. The second most common cutaneous adverse drug reaction observed in our study was urticaria comprising 26.2%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

Janardhan

Shailendra

2017

Int J Res Dermatol

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Background: An adverse cutaneous drug reaction (ACDR) is defined as an undesirable clinical manifestation resulting from administration of a particular drug. With an ever increasing number of drugs and varied formulations being continuously made available it is important that a close watch on the risks of adverse drug reactions is looked for, to ensure safe use of medicines in the interest of the patient. In the present study our aim is to study the prevalence & pattern of cutaneous adverse drug reactions reported to department of dermatology at MediCiti Institute of Medical Sciences, Hyderabad, India.Methods: All suspected cutaneous adverse drug reactions reported to the department of dermatology at MediCiti Institute of Medical Sciences during the two year period from January 2013 to December 2014 were included in this study. A thorough clinical examination of all these cases & details related to the drug use and clinical manifestations of the cutaneous adverse drug reaction were documented using a structured proforma. Naranjo scale was used to assess causality in all the causes of cutaneous adverse drug reactions.Results: The mean age of the patients was 42 years (age range: 1-64 years). Most of them were in the age group of 30-39 years. The male to female ratio was 1.78:1. The most common type of skin eruptions observed were maculopapular rash (35.55%), urticaria (26.19%) and fixed drug eruption (17.87%). The mean duration between drug intake and appearance of rash was 4 days (range: 1-120 days). Conclusions: The pattern of ACDRs and the drugs causing them in this study were similar to that reported in other studies both in terms of disease burden and clinical pattern. Knowledge of adverse cutaneous drug reactions will help to identify common medications contributing to dermatological reactions, so as to anticipate, prevent and limit their undue consequences.

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Section: Discussionmentioning

confidence: 99%

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

Janardhan

Shailendra

2017

Int J Res Dermatol

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“…The relationship between age and ACDR remains debatable as studies have shown controversial results. 4,10 It appears that males are more susceptible to ACDRs in general. 10,11 However, the exact reason for this phenomenon is yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…4,10 It appears that males are more susceptible to ACDRs in general. 10,11 However, the exact reason for this phenomenon is yet to be determined. 3 In this study, the Malay ethnic group contributed the highest number of ACDRs as they form the ethnic majority.…”

Section: Discussionmentioning

confidence: 99%

Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Talib¹,

Leelavathi

Hamzah

2015

South African Family Practice

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Background:Patients with adverse cutaneous drug reactions (ACDRs) are frequently referred from primary care to tertiary centres for further management. This causes a loss of information regarding ACDRs as these patients discontinue primary care follow-up upon referral to tertiary care. The aim of this study is to determine the prevalence and characteristics of ACDR, and to use this valuable information to enhance awareness of primary care physicians regarding this condition. Method: A retrospective cross-sectional study on ACDR was done at the Dermatology Clinic, Kuala Lumpur General Hospital from January 2009 to December 2010. Results: The prevalence of ACDR was 0.2%. The majority of patients (71.6%) were below 59 years of age. ACDR commonly (55.2%) occurs within hours to days of drug ingestion and is of mild to moderate severity (74.6%). About 27.6% of affected patients took 1 to 5 drugs concurrently. Common cutaneous manifestation of ACDR includes maculopapular rash (22.4%) and Stevens-Johnson syndrome (SJS, 9.7%). Antibiotics (36.6%), traditional and complementary medicine (TCM, 17.9%) and analgesics (13.4%) were the most frequent agents responsible for ACDR. Conclusion:The prevalence of ACDR in this study is low and the majority were of mild to moderate severity. The most common cutaneous manifestation was a maculopapular reaction and Stevens-Johnson syndrome. Antibiotics were the commonest causative agent for ACDR followed by traditional and complementary medicine and analgesics. Patients presenting with cutaneous disorders in primary care should be assessed for possible ACDR. A detailed drug history, time of initiation and duration of drug consumption are all valuable information required for an accurate diagnosis and proper evaluation of ACDR. It is hoped that the findings of this study will facilitate early recognition of ACDR followed by identification and elimination of any possible offending drugs that may be prescribed in primary care practice.

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“…La presencia de reacciones severas con alopurinol, sulfonamidas, particularmente cotrimoxazol, y con antiepilépticos es otra observación relevante y acorde con publicaciones internacionales 22 . Alopurinol provocó reacciones leves sólo en dos casos, al tiempo que cotrimoxazol en ninguno.…”

Section: Discussionunclassified

Reacciones adversas cutáneas a medicamentos: Vigilancia durante un año en un Hospital Universitario. Uruguay 2008-2009

Danza¹,

López²,

Vola³

et al. 2010

Rev. méd. Chile

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Cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia

Abstract: The most common reaction pattern seen in our study population was maculopapular eruptions. Antibiotics, anticonvulsants and NSAIDs were the most frequently implicated drug groups. Carbamazepine and allopurinol were the two main causative drugs of severe ADRs in our population.

Cited by 96 publications

References 20 publications

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Reacciones adversas cutáneas a medicamentos: Vigilancia durante un año en un Hospital Universitario. Uruguay 2008-2009

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