Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm

Halima, Ahmed; Pannunzio, A. M.; Erstine, Emily M.; Ko, Jennifer S.; Bergfeld, Wilma F.; Malaya, R. M.; Frankel, M. B.; Calhoun, Benjamin C.; Sturgis, Charles D.

doi:10.1155/2018/4039545

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…4 Although associated with trichoepithelioma and occasionally spiradenoma. 2,6 Cylindroma are conventionally classified as a neoplasm of apocrine differentiation, but the ultrastructural and immunohistochemical evidence of eccrine origin has been documented. 4 Massoumi et al stated that epithelial hair follicle origin and its exact pathology of differentiation (follicular vs apocrine vs sebaceous and even eccrine) may be dictated by the epithelial-mesenchymal signaling.…”

Section: Discussionmentioning

confidence: 99%

On‐site cytological diagnosis of cylindroma: A case report

Santosh

Puneeta

2020

Diagnostic Cytopathology

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A 70-year-old female presented with a swelling in the right auricle for 6 months. Rapid onsite stain and routine cytology revealed clusters of small, round to oval cells with hyperchromatic nuclei, inconspicuous nucleoli, and scant cytoplasm. The background had basement membrane type material and appeared dark magenta colored pinkish globular material. Hence a cytological diagnosis of skin adnexal tumor possibly cylindroma was made. The excision of the lesion also showed features of cylindroma. Rapid onsite staining and cytology of subcutaneous location of the tumor in the absence of primary salivary gland tumors may help to diagnose such rare cases. K E Y W O R D S cylindroma, cytology, histopathology, rapid onsite, toluidine blue 1 | BACKGROUND Cylindroma is a benign skin adnexal neoplasms of eccrine or apocrine origin. They most commonly occur on the head and neck as solitary or multiple tumors. 1 When multiple cylindromas occur on the scalp, they can grow together and resemble a hat or turban, giving rise to the previously more common term "turban tumor". 2 FNAC is a minimally invasive technique along with the use of rapid stain is an adjunct for sample adequacy and provisional diagnosis. 3 We report the cytological findings with an on-site correlation of such adnexal lesion. 2 | CASE PRESENTATION A 70-year-old female presented with swelling in right auricular swelling for the last 1 year. She had no other swelling in other parts of the body. On examination a well-defined painless lesion measuring 1.5 × 1.5 cm.

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Section: Discussionmentioning

confidence: 99%

On‐site cytological diagnosis of cylindroma: A case report

Santosh

Puneeta

2020

Diagnostic Cytopathology

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“…Cylindroma of the breast was rst described by Gokaslan et al in 2001 [4]. To the best of our knowledge, a total of eighteen cases of cylindroma of the breast have been reported in the literature so far (Table 1) [3][4][5][6][7][8][9][10][11][12][13]. Only two of these cases occurred in patients with known CYLD cutaneous syndrome.…”

Section: Introductionmentioning

confidence: 99%

Cylindroma of the breast with CYLD gene mutation: a case report and review of the literature

Escher-Michlig

Vlajnic

Roma

et al. 2023

Preprint

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Background Cylindroma of the breast is a rare benign neoplasm. Since its first description in 2001, 18 cases have been reported in the literature. Methods and Results We report another case of this rare tumor in a 60-year-old woman with demonstration of the underlying molecular alteration. Histologically, the tumor showed the typical “jigsaw” pattern of a dual population of cells with a triple-negative phenotype. The pathognomonic mutation of the CYLD gene mutation was detected by whole exome sequencing. Cylindromas show morphological overlap with the solid-basaloid variant of adenoid cystic carcinoma, which renders this differential diagnosis difficult. However, distinction of these two lesions is of outmost importance, since cylindromas, in contrast to solid-basaloid variant of adenoid cystic carcinoma, behave in an entirely benign fashion. Conclusions Careful evaluation of morphological features such as mitotic figures and cellular atypia is crucial in the diagnostic work-up of triple-negative breast lesions. It is important to keep cylindroma in mind as a pitfall and possible differential diagnosis for the solid-basaloid variant of adenoid cystic carcinoma. Molecular detection of CYLD gene mutation is helpful in cases with ambiguous histology. With this case report, we aim to contribute to a better understanding of mammary cylindroma and facilitate the diagnosis of this rare entity.

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Cylindroma of the breast with CYLD gene mutation: a case report and review of the literature

et al. 2023

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Background Cylindroma of the breast is a rare benign neoplasm. Since its first description in 2001, 20 cases have been reported in the literature. Methods and results We report another case of this rare tumor in a 60-year-old woman with demonstration of the underlying molecular alteration. Histologically, the tumor showed the typical “jigsaw” pattern of a dual population of cells with a triple-negative phenotype. The pathognomonic mutation of the CYLD gene mutation was detected by whole exome sequencing. Cylindromas show morphological overlap with the solid-basaloid variant of adenoid cystic carcinoma, which renders this differential diagnosis difficult. However, distinction of these two lesions is of outmost importance, since cylindromas, in contrast to solid-basaloid variant of adenoid cystic carcinoma, behave in an entirely benign fashion. Conclusions Careful evaluation of morphological features such as mitotic figures and cellular atypia is crucial in the diagnostic work-up of triple-negative breast lesions. It is important to keep cylindroma in mind as a pitfall and possible differential diagnosis for the solid-basaloid variant of adenoid cystic carcinoma. Molecular detection of CYLD gene mutation is helpful in cases with ambiguous histology. With this case report, we aim to contribute to a better understanding of mammary cylindroma and facilitate the diagnosis of this rare entity.

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Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm

Cited by 4 publications

References 36 publications

On‐site cytological diagnosis of cylindroma: A case report

On‐site cytological diagnosis of cylindroma: A case report

Cylindroma of the breast with CYLD gene mutation: a case report and review of the literature

Cylindroma of the breast with CYLD gene mutation: a case report and review of the literature

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