“…Jug et al [21], on the other hand, have proposed a rigorous mathematical abstraction of the joint problem which they call the moral lineage tracing problem (MLTP). It is a hybrid of the minimum cost multicut problem (MCMCP), which has been studied extensively for image decomposition [4,5,6,7,8,9,10,23,28,29,48,49], and the minimum cost disjoint arborescence problem, variations of which have been applied to reconstruct lineage forests in [22,24,36,41,40] or tree-like structures [15,46,45]. Feasible solutions to the MLTP define not only a valid cell lineage forest over time, but also a segmentation of the cells in every frame (cf.…”