Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer

Muller, Bart; Swaan, Abel; Bruin, Daniël M. de; Bos, Willemien van den; Schreurs, A. W.; Faber, Dirk J.; Zwartkruis, Evita; Rozendaal, Lawrence; Vis, André N.; Nieuwenhuijzen, Jakko A.; Moorselaar, R. Jeroen A. van; Leeuwen, Ton G. van; Rosette, Jean J.M.C.H. de la

doi:10.1177/1533034615626614

Cited by 15 publications

(17 citation statements)

References 34 publications

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“…Different from our previous ex-vivo studies, [12,23,24] the light seems to penetrate deeper in vivo for stroma compared with the Gleason patterns. This difference in penetration depth should be exploited in future studies by determining the optical attenuation coefficient.…”

Section: Comparing In Vivo Oct With Previously Published Atlascontrasting

confidence: 94%

“…This difference in penetration depth should be exploited in future studies by determining the optical attenuation coefficient. [12,23,24] The possibility of collecting good quality images of the prostate with needle-based OCT measurements is now the first successful step towards a larger cohort study that aims to correlate OCT with histology to set up in vivo discriminative parameters. [13] By using two highly selected patients with PCa prior to this proposed correlation study, we follow the IDEAL recommendations [25].…”

Section: Comparing In Vivo Oct With Previously Published Atlasmentioning

confidence: 99%

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The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

et al. 2019

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Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology. Three experts assessed all the corresponding OCT images. The OCT and biopsy conclusions for the corresponding regions were compared. Results No adverse events during and following the, in total four, in vivo needle‐based OCT measurements were reported. The OCT measurements showed images of prostatic tissue with a penetration depth of ~1.5 mm. The histological‐proven tissue types, which were also found in the overlapping OCT images, were benign glands, stroma, glandular atrophy, and adenocarcinoma (Gleason pattern 3). Conclusions Clinical in vivo needle‐based OCT of the prostate is feasible with no adverse events during measurements. OCT images displayed detailed prostatic tissue with a imaging depth up to ~1.5 mm. We could co‐register four histological‐proven tissue types with OCT images. The feasibility of in vivo OCT in the prostate opens the pathway to the next phase of needle‐based OCT studies in the prostate. Lasers Surg. Med. 51:390–398, 2019. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.

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Section: Comparing In Vivo Oct With Previously Published Atlascontrasting

confidence: 94%

Section: Comparing In Vivo Oct With Previously Published Atlasmentioning

confidence: 99%

The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

et al. 2019

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“…Four (in a small prostate) or six (in a large prostate) intravascular (IV)-catheters were placed in the prostate using the customized tool as described in previous work. 25 After removal of the insertion needle, the C7 dragonfly tm OCT probe was inserted into the in-situ transparent IV catheter and OCT measurements of the prostate tissue were acquired.…”

Section: Test Methodsmentioning

confidence: 99%

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

et al. 2018

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Diagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation were performed. OCT can reliably differentiate between fat, cystic, and regular atrophy and benign glands. The overall sensitivity and specificity for malignancy detection was 79% and 88% for reviewer 1 and 88% and 81% for reviewer 2. Quantitative analysis for differentiation between stroma and malignancy showed a significant difference (4.6 mm - 1 versus 5.0 mm - 1 Mann-Whitney U-test p < 0.0001). A Kruskal-Wallis test showed a significant difference in median attenuation coefficient between stroma, inflammation, Gleason 3, and Gleason 4 (4.6, 4.1, 5.9, and 5.0 mm - 1, respectively). However, attenuation coefficient varied per patient and a related-samples Wilcoxon signed-rank test showed no significant difference per patient (p = 0.17). This study confirmed the one to one correlation of histopathology and OCT. Precise matching showed that most histological tissues categories in the prostate could be distinguished by their unique pattern in OCT images. In addition, the optical attenuation coefficient can play a role in the differentiation between stroma and malignancy; however, a per patient analysis of the optical attenuation coefficient did not show a significant difference.

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“…The second part of the protocol enables one to one comparison of in vivo data with histology for both CLE and OCT. Our approach is similar to the approach of Muller et al [28], which compared ex-vivo needle-based OCT measurements of radical prostatectomy specimens with histology very precisely by cutting through the measurement trajectories. In our measurements data will be obtained from invivo tissue, in which red blood cells will absorb and scatter light different from regular cells.…”

Section: Benefits and Risksmentioning

confidence: 99%

“…A limited number of studies has looked at OCT's diagnostic role in differentiating benign and malignant microscopic tissue of the prostate gland. Muller et al demonstrated with the use of a histopathological validation tool that ex-vivo needle-based OCT measurements of radical prostatectomy specimens can differentiate between cancer and healthy prostate tissue [27][28][29]. The quantitative analysis of OCT signal by means of the attenuation coefficient was significantly higher in malignant compared to benign tissue with an area under the curve ranging from 0.64 -0.89 depending on the histopathological analysis used [29].…”

mentioning

confidence: 99%

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

Swaan¹,

Mannaerts²,

Scheltema³

et al. 2018

Preprint

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BackgroundFocal therapy for prostate cancer (PCa) has been proposed as an alternative treatment to wholegland therapies in selected men to diminish side effects in localized prostate cancer. Since existing PCa imaging cannot offer complete PCa disease characterization, multi-core systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy (CLE) and optical coherence tomography (OCT) allow in-vivo, high-resolution imaging, and can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. ObjectiveThis study has two seperate primary objectives. The first is to assess the technical feasibility and safety of in-vivo focal imaging with CLE and OCT. The second is to identify and define characteristics of PCa and normal prostate tissue in CLE and OCT imaging by comparing these images with the corresponding histopathology.

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Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer

Cited by 15 publications

References 34 publications

The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

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