Customizable Supraparticles Constructed from Catechol‐Terminated Molecular Building Blocks with Controllable Intermolecular Interactions**

Abstract

Colloidal supraparticles integrated with multicomponent primary particles come with emerging or synergetic functionalities. However, achieving the functional customization of supraparticles remains a great challenge because of the limited options of building blocks with tailorability and functional extensibility. Herein, we developed a universal approach to construct customizable supraparticles with desired properties from molecular building blocks obtained by the covalent conjugation of catechol groups with a series of orthogonal functional groups. These catechol-terminated molecular building blocks can assemble into primary particles driven by various intermolecular interactions (i.e. metalorganic coordination, host-guest, and hydrophobic interactions), and then further assemble into supraparticles governed by catechol-mediated interfacial interactions. Our strategy enables the formation of supraparticles with diverse functionalities, such as dual-pH responsiveness, light-controllable permeability, and non-invasive fluorescence labeling of living cells. The ease with which these supraparticles can be fabricated, and the ability to tailor their chemical and physical properties through the choice of metals and orthogonal functional groups used, should enable a variety of applications.

ZIF-90-decorated silica nanoparticles with a spiky surface: a novel approach to drug delivery

“…In this strategy, we fabricated zinc oxide (ZnO) on the SNP surface, which was later converted to ZIF-90 in the presence of 2-ICA. This is similar to the template-based synthesis of supraparticles; 24 here, SNP acts as a template for the growth of ZIF-90 nanoparticles. Dox was utilized as a model drug to investigate drug delivery and anti-cancer efficacy in breast cancer cells.…”

Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy

“…[5,11,17,18] Metal-phenolic networks (MPNs) are metal-organic materials constructed from metal ions and natural polyphenols, [19,20] where the physiochemical properties and functional performance can be tailored by careful selection of the metal ions and phenolic ligands. [21][22][23] MPNs have exhibited translational potential owing to their rapid formation (less than 10 s) and versatile functionalities as well as feasible deposition on a wide range of inorganic, organic, and biological substrates. For example, we have previously demonstrated that MPNs can form biomimetic nanocloaks on the surface of individual bacteria, [24] yeast, [25] and mammalian cells.…”

Hierarchical Self‐Assembly Molecular Building Blocks as Intelligent Nanoplatforms for Ovarian Cancer Theranostics

“…Hierarchical self-assembly from simple to complex is the most basic substance synthesis strategy in nature, which is of great significance for the in-depth understanding of the assembly process from molecular, nano to macro scale. [1][2][3] It also provides gynecology. [21][22][23] In recent years, the number of ovarian cancer patients worldwide has increased year by year, and the majority of ovarian cancer patients are already at the advanced stage when first diagnosed, and the five-year survival rate is less than 30%.…”