Customizable molecular recognition: advancements in design, synthesis, and application of molecularly imprinted polymers

Abstract

Molecularly imprinted polymers (MIPs) are where the complexity of receptor proteins meets the tunability of synthetic research. Receptor proteins, such as enzymes or antibodies, have functional cavities that act as...

Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids

“…34 Interactions within the polymer matrix, between the newly shaped polymer backbone and template, results in the installation of molecular recognition. 26 These high-affinity binding sites are revealed subsequent to template extraction due to the formation of cavities complementary in shape, size, and chemical functionality to that of the template and closely related functional analogues. 35,36 Molecular imprinting is classified according to the relationship between the MIP and the non-imprinted polymer (NIP) species.…”

“…[17][18][19] MIPs have the potential to address many of the current challenges associated with antibody-based diagnostics, including complicated manufacture and handling, long-term stability, and loss of performance in organic media. 17,[20][21][22][23][24][25][26][27] MIPs are reasonably inert materials that can be exploited as affordable artificial receptors for biological sensor purposes owed to their selective, specific, biologically stable, and easily tailored (e.g., surface chemistry modifications and/or signalling functionalities) nature in combination with their exceptional physicochemical abilities and extensive shelf-life. 17,[20][21][22][23][24][25]27 Thus, exploitation of these material properties could facilitate improved biomarker detection and analysis compared to clinical biological receptors.…”

A Fusion of Molecular Imprinting Technology and Siloxane Chemistry: A Way to Advanced Hybrid Nanomaterials

“…Molecular imprinting technology is a well-known strategy that allows the synthesizing of materials with a predetermined specificity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. The “classical” approach, described by Wulff and Sarhan [ 8 , 9 , 10 ] in the early 1970s, assumed the creation of “memory sites” in the organic polymer matrix by a template molecule that covalently interacts with the functional monomer prior to polymerization and chemical cleavage for template residue removal.…”

Synthesis of molecularly imprinted polymer based on cooperative imprinting for enrichment of gallic acid in Puer tea

“…The synthesis of MIP is implemented by the copolymerization of template and functional monomers in the presence of crosslinkers. After removal of the template, the imprinting sites complementary to the target in MIP can recognize and rebind the template molecules in complex matrices 13 . The MIPs for separation and purification of target substances have been successfully used in food, biological and environmental samples because of their easy preparation, mechanical/chemical stability, low cost and high specificity 14–18 .…”

“…After removal of the template, the imprinting sites complementary to the target in MIP can recognize and rebind the template molecules in complex matrices. 13 The MIPs for separation and purification of target substances have been successfully used in food, biological and environmental samples because of their easy preparation, mechanical/chemical stability, low cost and high specificity. [14][15][16][17][18] Therefore, the MIP is a friendly adsorbent to separate and purify GA from complex samples and several diverse approaches have been developed.…”