Custom-modified oligolactide-cyclodextrin derivatives for electrospun drug formulations

Peptu, Cristian; Blaj, Diana-Andreea; Balan-Porcăraşu, Mihaela; Peptu, Cătălina Anişoara; Harabagiu, Valeria

doi:10.1016/j.eurpolymj.2023.112234

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…β-CD is an environmentally friendly and harmless organic compound that can enhance the stability of drugs in the pharmaceutical industry. β-CD and its derivatives also have a certain effect on the treatment of heavy metals in water [ 32 , 33 ]. β-CD contains a large number of hydroxyl reactive functional groups and has the potential to be used as a green depressant in the flotation process.…”

Section: Introductionmentioning

confidence: 99%

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Li,

Xie,

et al. 2024

PLoS ONE

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High-density waste drilling fluid contains an abundance of recyclable weighting reagents, direct disposal can pollute the environment. In this paper, the primary mineral composition of a high-density waste drilling fluid from a well in the southwest oil and gas field was analyzed. This paper proposes β-cyclodextrin (β-CD) as a depressant for the recovery of barite from waste drilling fluid. The recovery process was investigated through inverse flotation experiments, and the mechanism was analyzed using zeta potential, contact angle analysis, and FTIR. The flotation experiments showed that under the SDS flotation system, when the pH was 9.0 and the amount of depressant β-CD was 900 g/t, the barite recovery and density reached the highest values, which were 87.41% and 4.042 g/cm3, respectively. Zeta potential experiments, contact angle analysis, and FTIR analysis indicate that β-CD adsorbed onto barite through enhancing the hydrophilicity of barite, electrostatic force adsorption, and strong adsorption, which could not be displayed by SDS through competitive adsorption. Furthermore, β-CD exhibited a selective inhibitory effect on barite and enabled reverse flotation. The mechanism model of the flotation separation process was established.

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Section: Introductionmentioning

confidence: 99%

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Li,

Xie,

et al. 2024

PLoS ONE

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Synthesis of β-cyclodextrin derivatives substituted at larger or smaller rims via amine-catalyzed ring-opening oligomerization of ε-caprolactone

Blaj,

Balan-Porcarasu,

Harabagiu

et al. 2024

Carbohydrate Polymers

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Enrofloxacin Pharmaceutical Formulations through the Polymer-Free Electrospinning of β-Cyclodextrin–oligolactide Derivatives

Blaj,

Peptu,

Danu

et al. 2024

Pharmaceutics

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Enrofloxacin (ENR), a member of the fluoroquinolone class of antibiotics, is widely used in veterinary medicine to treat bacterial infections. Like many antibiotics, ENR has limited water solubility and low bioavailability. To address these challenges, drug formulations using solid dispersions, nanosuspensions, surfactants, cocrystal/salt formation, and inclusion complexes with cyclodextrins may be employed. The approach described herein proposes the development of ENR formulations by co-electrospinning ENR with custom-prepared cyclodextrin–oligolactide (CDLA) derivatives. This method benefits from the high solubility of these derivatives, enabling polymer-free electrospinning. The electrospinning parameters were optimized to incorporate significant amounts of ENR into the CDLA nanofibrous webs, reaching up to 15.6% by weight. The obtained formulations were characterized by FTIR and NMR spectroscopy methods and evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. This study indicates that the presence of CDLA derivative does not inhibit the antibacterial activity of ENR, recommending these formulations for further development.

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Custom-modified oligolactide-cyclodextrin derivatives for electrospun drug formulations

Cited by 3 publications

References 72 publications

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Synthesis of β-cyclodextrin derivatives substituted at larger or smaller rims via amine-catalyzed ring-opening oligomerization of ε-caprolactone

Enrofloxacin Pharmaceutical Formulations through the Polymer-Free Electrospinning of β-Cyclodextrin–oligolactide Derivatives

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