As death is final outcome of life, it is inevitable in prisoners too. Pattern of deaths can reveal living conditions and practices in a population. This study was conducted to observe the pattern of natural deaths among prisoners autopsied at a tertiary care hospital in Jaipur during April 2017 to March 2018. During this period 16 cases of alleged natural deaths in custody were autopsied comprising of 15 males and 1 female. The natural deaths were almost evenly distributed in all age groups. Carcinoma was leading cause of death in (37.5%) cases, followed by cardio-vascular causes in (25%) cases, intracranial hemorrhage in (12.5%) cases, septicaemia in (12.5%) cases, tuberculosis associated with HIV in (6.25%) case and Pneumonia associated with Parkinsonism in (6.25%) cases. All (100%) of the natural deaths received medical attention prior to death and died in hospital. Injuries were present in 5 cases (31.25%) but were not attributed to causing deaths.