Cushing Syndrome in a Pediatric Patient with Topical Steroid Overuse

Kuikel, Sandip; Aryal, Sunil; Basnyat, Rupesh Shingh; Rimal, Suman

doi:10.1155/2022/8487737

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…Though rare, Cushing's syndrome (CS) has been reported in children. [1][2][3][4][5][6][7][8][9][10][11][12][13] Aitafo et al reported Cushing's syndrome as being responsible for <1% of all cases presenting in the Paediatric Endocrinology clinic in South-south Nigeria. 12 This is similar to that reported by Tamunopriye et al where CS was responsible for 0.5% of all cases seen.…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with common manifestations of Cushing's syndrome reported-obesity, moon face, hirsutism, muscle weakness, hypertension and glucose intolerance. 13,15 Hypertension is seen in up to 80% of patients with CS and correlates with the duration of hypercortisolism. 16 Azzoug et al reported hypertension in 67% of patients with CS, 33% of whom had glucose intolerance.…”

Section: Discussionmentioning

confidence: 99%

“…Her mother continued giving her prednisolone for several months and only presented in the hospital when she became concerned about the excessive weight gain. Several authors have reported Cushing's syndrome secondary to prolonged and inappropriate use of potent topical corticosteroids 13,19,20 as well as nasal steroid in children. 9 Our patient had features suggestive of a Pseudo-precocious puberty as her breast were enlarged -Tanner stage 2 and she had developed pubic hair -Tanner stage 2.…”

Section: Discussionmentioning

confidence: 99%

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Cushing’s Syndrome Secondary to Steroid Abuse

Enekole Aitafo,

Imafidon,

Onubogu

2024

Int J Health Sci Res

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Introduction: Cushing’s syndrome, a rare endocrine disorder may result from exogenous administration of steroids. Case Report: E.P, 4 years old female presented to RSUTH at 3 years 7 months with complaints of speech delay and difficulty standing from sitting position. She had left convergent squint, Grade 3/6 systolic murmur and proximal muscle weakness. Initial diagnosis was ‘Duchenne muscular dystrophy and Acyanotic congenital heart disease’. Echocardiography revealed Atrial and Ventricular Septal Defects. Creatine kinase was normal. She was placed on tabs prednisolone, furosemide, spironolactone and physiotherapy; counselled and booked for follow-up in 2 weeks. She defaulted from follow-up and continued to give Prednisolone. Five months later, she presented to the Cardiology clinic with excessive weight gain and breast development. She had moon face, truncal obesity, and elevated BP. She was referred to the Endocrinology clinic where, in addition, cushingoid appearance, hirsutism, acanthosis nigracans, a hump, striae, with a left convergent squint were noted. Breast was Tanner stage 2. Diagnosis was Cushing’s syndrome secondary to Steroid Abuse, Stage 2 hypertension, Premature thelarche? Diabetes mellitus? Pituitary tumour. Brain MRI and abdominal USS were normal. HbA1c was elevated, insulin, C-peptide and Adrenocorticotropic hormone (ACTH) levels were reduced. Other hormonal indices were normal. She was given tabs Amlodipine and Prednisolone stopped. She steadily improved. Six months later, her blood pressure and sugar had normalized. Conclusion: Cushing’s syndrome though rare may occur secondary to steroid abuse. Strict compliance to doctor’s prescription and follow up cannot be over emphasized. Key words: Cushing’s, Syndrome, Steroid, Abuse

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