Cushing's syndrome produced by a pituitary basophil carcinoma with hepatic metastases

Sheldon, Walter H.; Golden, Abner; Bondy, Philip K.

doi:10.1016/0002-9343(54)90214-4

Cited by 59 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the metastases, however, caused problems such as pain or local compression due to local growth in liver [12,21,25,27,32,39,45], bones [8,11,14,18,26,35], and the central nervous system [15,17,21,22,24,[29][30][31]. In nine cases metastases were found only by postmortem analysis in the liver, intracranial, meninges, and spinal cord [16,19,20,28,34,36,38,43,47]. Within the central nervous system, metastatic sites were intracranial in 43%, and extracranial in 24%.…”

Section: Discussionmentioning

confidence: 99%

“…Within the central nervous system, metastatic sites were intracranial in 43%, and extracranial in 24%. Extramedullary metastases (62% of the cases) were mostly reported in the liver [3,11,12,14,16,20,21,25,27,32,35,36,39,[41][42][43][44][45], lymph nodes [3,12,31,40,48], and bone [3, 11, 14, 18, 21, 22, 25-27, 39, 40, 42].…”

Section: Discussionmentioning

confidence: 99%

“…Time interval to death in the other four cases ranged from 0.4 to 2.7 years [3,15,22,40]. In 10 cases, metastases were found only in the liver [16,20,21,32,36,38,[42][43][44][45]. Of those patients, two were still alive at publication.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature

et al. 2008

View full text Add to dashboard Cite

Corticotroph pituitary carcinomas are tumors, defined by the presence of distant metastases that determine their poor prognosis. The diagnosis and therapy of malignant corticotroph adenomas remains a clinical challenge. The molecular mechanisms of malignant transformation of pituitary adenomas are unclear, although they are believed to arise in an adenoma-to-carcinoma sequence. We describe two cases of malignant Cushing's disease with metastases in liver and bone, respectively. The primary pituitary tumors were treated by a combination of radiotherapy and transsphenoidal surgery, but recurred several times in both patients. The time interval between the diagnosis of Cushing's disease and the discovery of metastases was 32 and 17 years, respectively. In the first case the patient died within 6 months after diagnosis of metastasis, whereas the second patient is alive at a followup of 2 years after the discovery of the metastasis. Furthermore, we reviewed all available cases of corticotroph pituitary carcinomas reported in the literature and analyzed their clinical features and therapeutical management. In conclusion, frequent relapses of Cushing's disease, aggressive growth of macroadenoma, Nelson's syndrome after adrenalectomy or persistently high ACTH levels should prompt the clinician to consider the possibility of pituitary corticotroph carcinomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature

et al. 2008

View full text Add to dashboard Cite

show abstract

“…and Bondy (9). In Forbes' patient the primary tumor was found to contain predominantly chromophobe cells, whereas the cells of the liver metastases were mostly eosinophilic.…”

Section: Autopsymentioning

confidence: 89%

Carcinoma of the Hypophysis Associated With Cushing's Syndrome and Addisonian Pigmentation

Haugen¹,

Löken²

1960

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

A patient suffering from Cushing's syndrome associated with carcinoma of the hypophysis and Addisonian pigmentation is described. It is pointed out that in a patient with Cushing's syndrome, distinct pigmentation may suggest carcinoma of the hypophysis, particularly when combined with an enlarged sella turcica and lack of response to irradiation of the pituitary area. I N A patient suffering from Cushing's syndrome recently seen in this hospital a carcinoma of the hypophysis was found at autopsy. The patient also showed a characteristic Addisonian pigmentation, and for this reason the case is considered worthy of publication. CASE REPORTThe patient was a 51-year-old housewife who previously had been in good health. From January 1955 she complained of polydipsia, pigmentation of the skin, particularly of the face, the neck and the abdomen. There was growth of hair on the face, necessitating shaving once a week. She also complained of frequent headaches and nausea. Little by little she became apathetic and her muscular and intellectual powers declined. Her menstrual periods had stopped two years previously. In April 1956 the positive findings in a local hospital were a Cushingoid habitus, eosinopenia, decreased glucose tolerance and an enlarged sella on x-ray examination. These findings were confirmed in the neurological department of this hospital, and she was transferred to the medical department for further study and treatment.On admission on May 30, 1956, she felt reasonably well except for asthenia. Her face was round and plethoric with slight hirsutism. She was obese, the obesity being limited to the face, neck, shoulders and abdomen; the extremities were thin. She had many purplish striae over the abdomen, and also ecchymotic areas, particularly over the upper extremities. Her face, chest and abdomen were deeply pigmented, as were the palms of the hands, the knuckles of the fingers, and the elbows. Areolar pigmentation was increased. No oral pigmentation, and no freckles, vitiligo or leukoderma were observed. The blood pressure was 145 mm. Hg systolic and 95 mm. diastolic. Laboratory data: The hemoglobin level and red and white blood cell counts were within normal limits. There were 19 eosinophils per cu. mm. The oral glucose tolerance test after 50 Gm. of glucose showed the following blood sugar levels: control, 109 mg. per 100 ml.; thirty minutes, 219 mg.; one hour, 224 mg.; two hours, 153 mg.; and three

show abstract

“…Only 60 cases have been reported to date (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The diagnosis depends on the demonstration of intracranial or extracranial metastases (17,18) as there are no unequivocal histological characteristics of pituitary carcinoma (18).…”

Section: Introductionmentioning

confidence: 99%

ACTH-producing carcinoma of the pituitary with haematogenic metastases

Garrao

Sobrinho²,

Pedro-Oliveira³

et al. 1997

European Journal of Endocrinology

View full text Add to dashboard Cite

The case report is presented of a 47-year-old white woman with Cushing's disease treated by bilateral adrenalectomy in June 1981. A first computed tomography (CT) scan in September 1984 showed a voluminous pituitary adenoma with invasion of the sphenoid sinus and left parasellar extension. The tumour increased progressively in size, a suprasellar extension developed and the optic chiasm was eventually affected. In March 1988 and June 1989 the patient underwent two surgeries for the pituitary tumour, the second followed by radiotherapy. During this period, the ACTH values varied between 100 pmol/l and 403 pmol/l (normal: <13 pmol/l). After radiotherapy, a progressive shrinking of the tumour was observed and the ACTH concentrations decreased to a lowest value of 27.5 pmol/l. The patient was clinically well until September 1993 when, suddenly, the plasma ACTH concentration increased to very high levels (greater than 965 pmol/l). There was no evidence of tumour growth on the sellar CT scan. In January 1995, an ACTH-producing pituitary carcinoma was diagnosed, based on the presence of bone metastases. The patient died in May 1995.

show abstract

Cushing's syndrome produced by a pituitary basophil carcinoma with hepatic metastases

Cited by 59 publications

References 13 publications

Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature

Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature

Carcinoma of the Hypophysis Associated With Cushing's Syndrome and Addisonian Pigmentation

ACTH-producing carcinoma of the pituitary with haematogenic metastases

Contact Info

Product

Resources

About