Cushing’s Syndrome Is Associated With Early Medical- and Surgical-Related Complications Following Total Joint Arthroplasty: A National Database Study

McCormick, Brian P; Sequeira, Sean B.; Hasenauer, Mark D.; McKinstry, Robert; Boucher, Henry R.

doi:10.1016/j.arth.2023.06.010

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…Despite now being quite rare, infections can follow the procedure; in addition, some studies have associated the treatment with local side effects like necrosis, tendon weakening, and cartilage reduction [174][175][176][177]. On the other hand, despite being rare, some systemic responses to the drug may be observed, like headache, insomnia, short-term glucose levels increase, hypothalamic-pituitary-adrenal axis suppression, and iatrogenic Cushing syndrome [178][179][180].…”

Section: Steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

Coppola,

Greco,

Munir

et al. 2024

CIMB

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Osteoarthritis (OA) stands as a prevalent and progressively debilitating clinical condition globally, impacting joint structures and leading to their gradual deterioration through inflammatory mechanisms. While both non-modifiable and modifiable factors contribute to its onset, numerous aspects of OA pathophysiology remain elusive despite considerable research strides. Presently, diagnosis heavily relies on clinician expertise and meticulous differential diagnosis to exclude other joint-affecting conditions. Therapeutic approaches for OA predominantly focus on patient education for self-management alongside tailored exercise regimens, often complemented by various pharmacological interventions primarily targeting pain alleviation. However, pharmacological treatments typically exhibit short-term efficacy and local and/or systemic side effects, with prosthetic surgery being the ultimate resolution in severe cases. Thus, exploring the potential integration or substitution of conventional drug therapies with natural compounds and extracts emerges as a promising frontier in enhancing OA management. These alternatives offer improved safety profiles and possess the potential to target specific dysregulated pathways implicated in OA pathogenesis, thereby presenting a holistic approach to address the condition’s complexities.

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