Cushing's Syndrome Associated with Galactorrhea, Amenorrhea, and Hypothyroidism: A Primary Hypothalamic Disorder

Berlinger, Frederick G.; Ruder, Henry J.; Wilber, John F.

doi:10.1210/jcem-45-6-1205

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Report Of a Case1

Disorders With Associated Obesity and Menstrual Dysfunction1

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1979

1990

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Cited by 14 publications

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“…A patient with Cushing's disease, postpartum galactorrhea, hypothalamic hypothyroidism and hypothalamic amenorrhea was described by Berlinger et al (1977) …”

Section: Report Of a Casementioning

confidence: 99%

Cushing's syndrome associated with corticogenic hypothyroidism: A case study.

et al. 1981

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Described here is a 27-year-old female, who had centripetal obesity, broad reddishpurple striae on the lower abdomen and hypertension.Serum cortisol levels, the results of a dexamethasone suppression test and an adrenal scintigram with 131I-19-iodocholesterol were all compatible with Cushing's syndrome due to an adrenal adenoma that secretes cortisol autonomously.This was confirmed by gross and microscopic examination of the removed adrenal tumor. In addition, the patient had markedly diminished T4 and T3 concentrations in serum. Basal TSH levels were not elevated and did not rise significantly after TRH injection.Serum T4 and T3 concentrations were elevated to the normal range when the hyperadrenocorticism was corrected.The results indicate that the patient had "corticogenic hypothyroidism."

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“…A patient with Cushing's disease, postpartum galactorrhea, hypothalamic hypothyroidism and hypothalamic amenorrhea was described by Berlinger et al (1977) …”

Section: Report Of a Casementioning

confidence: 99%

Cushing's syndrome associated with corticogenic hypothyroidism: A case study.

et al. 1981

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“…92 In hypothalamic Cushing's disease a combined effect of central seroton- ergic overactivity and peripheral acyclic estrogen feedback may result in amenorrhea. 93 In Cushing's syndrome due to other causes, an acyclic high estrogen feedback mechanism may initially operate, but with time the state of chronic anovulation may lead to associated PCOD. 92 Although some women with primary hypothyroidism gain weight, true obesity is uncommon.…”

Section: Disorders With Associated Obesity and Menstrual Dysfunctionmentioning

confidence: 99%