Cushing's Disease as a Psychosomatic Disorder: A Selective Review of the Clinical and Experimental Literature and a Report of Ten Cases

Gifford, Sanford R.; Gunderson, John G.

doi:10.1353/pbm.1970.0019

Cited by 34 publications

(2 citation statements)

References 60 publications

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“…1913). Later work (Gi/ford et al, 1970;Sonino et al, 1988) proposed that Cushing's disease may have a psychosomatic component -a hypothesis that remains to be tested.…”

Section: Early Behavioral Symptomsmentioning

confidence: 99%

Psychiatric Phenomenology in Cushing's Disease

Loosen¹,

Chambliss

Debold

et al. 1992

Pharmacopsychiatry

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We evaluated 20 patients with Cushing's disease (i.e., Cushing's syndrome due to ACTH-secreting pituitary microadenoma) and 20 patients with Major Depressive Disorder (MDD) using the Structured Clinical Interview for DSM-III-R (SCID) and Research Diagnostic Criteria. The diagnosis of Generalized Anxiety Disorder (GAD) was most common in Cushing's disease (79%), followed by MDD (68%), and Panic Disorder (PD) including subthreshold PD (53%). The combination of MDD and GAD and/or PD was also common in Cushing's disease (63%). Behavioral symptoms, if present, usually first occurred at or after the onset of the first physical symptoms. However, the onset of PD was associated with more chronic stages of Cushing's disease. In both Cushing's disease and MDD, more female than male relatives suffered from MDD, whereas more male than female relatives suffered from substance abuse. The data demonstrate a syndrome of anxious depression in patients with active Cushing's disease; such comorbidility has not been previously noted. The data also point to intriguing epidemiological, clinical, and biological associations between Cushing's disease, MDD and substance abuse.

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“…1913). Later work (Gi/ford et al, 1970;Sonino et al, 1988) proposed that Cushing's disease may have a psychosomatic component -a hypothesis that remains to be tested.…”

Section: Early Behavioral Symptomsmentioning

confidence: 99%

Psychiatric Phenomenology in Cushing's Disease

Loosen¹,

Chambliss

Debold

et al. 1992

Pharmacopsychiatry

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“…Finally, Cushing's disease has been postulated to be actually a psychophysiologic response to bereavement or its emotional equivalent in predisposed individuals with disturbed hypothalamic pituitary regulation of adrenal activity (36).…”

Section: Hyperadrenalism (Cushing's Disease)mentioning

confidence: 99%

Psychiatric Disturbance in Endocrinologic Disease

Smith

Barish

Donate-Correa

et al. 1972

Psychosomatic Medicine

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Because mentation is dependent on the biochemical milieu of the nervous system, it is important to investigate the role of endocrine and metabolic abnormalities in psychiatric disorders. Disturbances of certain physiologic parameters such as the level of calcium, steroid hormones, glucose and thyroid hormones result in profound changes in mentation. Many of these are reversed by correcting the underlying abnormality.

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