Cushing Disease Revealed by Bilateral Atypical Central Serous Chorioretinopathy: Case Report

Giovansili, Iama; Belange, Georeges; Affortit, Aude

doi:10.4158/ep12389.cr

“…Bilateral atypical central serous chorio-retinopathy and exophthalmos are rare complications [73,74]. Orbital fat volume is increased in CS patients, but in contrast to Graves' disease, there is no infiltration by inflammatory cells, while the orbital muscles are relatively spared [74].…”

Section: Visual Disordersmentioning

confidence: 99%

Clinical and biochemical manifestations of Cushing’s

Ntali

¹

,

Grossman

²

,

Karavitaki

³

2015

View full text Add to dashboard Cite

show abstract

“…The disease affects mainly young and active people aged between 20 years and 50 years, with strong dominance of males. [1] It has also been recognized as accompanying systemic diseases or treatments [2,3,4] Risk factors listed most often include stress, type A personality, high testosterone serum levels in men, hyperopia and systemic vascular diseases such as hypertension or high heart rate. [5,6,7,8,9] At present, most authors agree that the pathology is localized in the choroid rather than in the retinal pigment epithelium (RPE).…”

Section: Introductionmentioning

confidence: 99%

Impairment of visual acuity and retinal morphology following resolved chronic central serous chorioretinopathy

Gawęcki¹,

Jaszczuk-Maciejewska²,

Jurska-Jaśko³

et al. 2019

Preprint

1

0

View full text Add to dashboard Cite

Purpose Central serous chorioretinopathy(CSCR) is a complex ocular entity that, in its chronic form, can lead to serious visual impairment and morphological damage to the retina. The aim of the current retrospective study was to evaluate the damage present after long-standing but resolved central serous chorioretinopathy and refer it to healthy individuals. Correlations between measurable factors—for example, duration of the disease, baseline retinal morphological parameters, or patient age and/or their degree of impairment—were also assessed. Materials and methods The study group consisted of thirty-two eyes (13 female and 19 male, mean age 49.6 years SD +/- 10.5) with chronic central serous chorioretinopathy ( mean duration 18.9 months SD +/- 15.4) in which complete resolution of subretinal fluid was achieved after subthreshold micropulse laser treatment. Inclusion criterion was a lack of subretinal fluid within the whole area of the central retina scanned by the spectral domain optical coherence tomography. The group was extracted out of 51 cases of chronic CSCR that were treated with that method. They were analyzed according to final best-corrected visual acuity and retinal morphological parameters as measured by spectral optical coherence tomography with angiography option (OCTA). Results were compared with the outcomes of a control group, which consisted of 40 eyes of healthy individuals with full distance visual acuity (0.0 logMAR, 1.0 Snellen) never treated with subthreshold micropulse laser. Statistical analysis included regarding correlation between final visual acuity and final central retinal thickness and retinal and functional parameters prior to treatment. Results Final best-corrected visual acuity after chronic central serous chorioretinopathy was 0.23 logMAR (0.6 Snellen) and central retinal thickness was 39.32 µm smaller than in controls. No correlation was found between final visual acuity and retinal thickness and duration of the disease, patient age, and baseline morphological retinal parameters. OCTA scans revealed impaired choriocapillaries flow signal even following resolution of the disease. Conclusion Chronic central serous chorioretinopathy is a potentially damaging clinical entity that results in serious visual impairment, retinal thinning, and choroidal flow defects. Further research is needed to determine precisely the timepoint of this damage.

show abstract

“…[1] It has also been recognized as accompanying systemic diseases or treatments [2,3,4] Risk factors listed most often include stress, type A personality, high testosterone serum levels in men, hyperopia and systemic vascular diseases such as hypertension or high heart rate. [5,6,7,8,9] At present, most authors agree that the pathology is localized in the choroid rather than in the retinal pigment epithelium (RPE).…”

Section: Introductionmentioning

confidence: 99%

Impairment of visual acuity and retinal morphology following resolved chronic central serous chorioretinopathy

Gawęcki¹,

Jaszczuk-Maciejewska²,

Jurska-Jaśko³

et al. 2019

Preprint

0

View full text Add to dashboard Cite

Purpose Central serous chorioretinopathy(CSCR) is a complex ocular entity that, in its chronic form, can lead to serious visual impairment and morphological damage to the retina. The aim of the current retrospective study was to evaluate the damage present after long-standing but resolved central serous chorioretinopathy and refer it to healthy individuals. Correlations between measurable factors—for example, duration of the disease, baseline retinal morphological parameters, or patient age and/or their degree of impairment—were also assessed. Materials and methods The study group consisted of thirty-two eyes (13 female and 19 male, mean age 49.6 years SD +/- 10.5) with chronic central serous chorioretinopathy ( mean duration 18.9 months SD +/- 15.4) in which complete resolution of subretinal fluid was achieved after subthreshold micropulse laser treatment. Inclusion criterion was a lack of subretinal fluid within the whole area of the central retina scanned by the spectral domain optical coherence tomography. The group was extracted out of 51 cases of chronic CSCR that were treated with that method. They were analyzed according to final best-corrected visual acuity and retinal morphological parameters as measured by spectral optical coherence tomography with angiography option (OCTA). Results were compared with the outcomes of a control group, which consisted of 40 eyes of healthy individuals with full distance visual acuity (0.0 logMAR, 1.0 Snellen) never treated with subthreshold micropulse laser. Statistical analysis included regarding correlation between final visual acuity and final central retinal thickness and retinal and functional parameters prior to treatment. Results Final best-corrected visual acuity after chronic central serous chorioretinopathy was 0.23 logMAR (0.6 Snellen) and central retinal thickness was 39.32 µm smaller than in controls. No correlation was found between final visual acuity and retinal thickness and duration of the disease, patient age, and baseline morphological retinal parameters. OCTA scans revealed impaired choriocapillaries flow signal even following resolution of the disease. Conclusion Chronic central serous chorioretinopathy is a potentially damaging clinical entity that results in serious visual impairment, retinal thinning, and choroidal flow defects. Further research is needed to determine precisely the timepoint of this damage.

show abstract

Cushing Disease Revealed by Bilateral Atypical Central Serous Chorioretinopathy: Case Report

Cited by 14 publications

References 17 publications

Clinical and biochemical manifestations of Cushing’s

Clinical and biochemical manifestations of Cushing’s

Impairment of visual acuity and retinal morphology following resolved chronic central serous chorioretinopathy

Impairment of visual acuity and retinal morphology following resolved chronic central serous chorioretinopathy

Contact Info

Product

Resources

About