Curvularia Abscess of the Brainstem

Skovrlj, Branko; Haghighi, Maryam; Smethurst, Mark E.; Caridi, John M.; Bederson, Joshua B.

doi:10.1016/j.wneu.2013.07.014

Cited by 13 publications

(17 citation statements)

References 25 publications

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“…It has been rarely implicated in human infections, but reports of endocarditis, skin infections, keratitis, pneumonia, sinusitis and disseminated disease have been documented [1]. Brain abscess secondary to Curvularia is extremely uncommon, with only 8 cases reported in the literature [2]. This fungus invades the brain mostly by contiguous extension from paranasal sinuses; however, hematogenous dissemination or direct inoculation from penetrating trauma are also possible mechanisms [3].…”

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confidence: 99%

Fatal Curvularia brain abscess in a heart and kidney transplant recipient

Zamora

Varadarajalu

2019

IDCases

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A 42-year-old woman with history of heart failure status post orthotopic heart transplant and end stage renal disease presented to the hospital with decompensated heart failure that progressed to cardiogenic shock. She underwent a new orthotopic heart transplant and cadaveric donor kidney transplant. Three weeks later, she experienced right facial droop and right upper extremity weakness. Computed tomography showed a left frontal cortical lesion with vasogenic edema and a central hemorrhagic component. Given the concern for an angioinvasive mold infection, she was started on voriconazole and amphotericin B. Brain biopsy was performed and histopathology revealed septated hyphae with acute angle branching. Mycology culture isolated Curvularia sp. Unfortunately, her mental status deteriorated with subsequent development of multiorgan failure that led to death.

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confidence: 99%

Fatal Curvularia brain abscess in a heart and kidney transplant recipient

Zamora

Varadarajalu

2019

IDCases

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“…Brainstem abscess, like any infection, also show higher incidence in people with certain predisposing factors such as immune deficiency syndromes like HIV infections, diabetes, and congenital heart diseases. [2] The cause of brainstem abscess is usually a hematogenous dissemination from a distant source of infection [4] and although the source of the infection is frequently apparent [13][14][15] still the definite cause remain obscure in up to 30 % of patients. [2,6,8] Our patient presented above shows no definite site of infection although we search for that retrospectively.…”

Section: Discussionmentioning

confidence: 99%

Pediatric brainstem abscess: a case-based review

Almuhammed¹

2016

MJBU

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ASTRACTSolitary brainstem abscess is uncommon condition with high mortality and morbidity. The diagnosis require high index of suspicion and appropriate imaging. It can be managed by medical treatment alone, stereotactic aspiration of the purulent material, or by surgical drainage along with medical therapy. Here, I present a case of a child with large solitary brainstem abscess involving the pons and the medulla oblongata without systemic infection or systemic predisposing factors. The patient managed by mean of microsurgical drainage and antibiotic therapy. The literatures on brainstem abscess was reviewed and an over view of the literature is presented. This case-based review of brainstem abscess reinforce the conclusion that early diagnosis and proper management with microsurgical drainage and maximal medical therapy may result in a good prognosis.

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“…Curvularia infections can manifest as mycotic keratitis [5], cutaneous and subcutaneous mycosis [6], onychomycosis [7], peritonitis [8], and allergic sinusitis [8,9]. Deep infections frequently affect the central nervous system [8][9][10]. Development of disseminated mycoses has been reported in both immunocompromised and immunocompetent patients [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal Pathogen Curvularia lunata

et al. 2020

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Curvularia lunata is an ascomycete filamentous fungus causing local and invasive phaeohyphomycoses in both immunocompromised and immunocompetent patients. Neutrophils are crucial participants of the first line host defense against fungal infections. They migrate to the infected site and eliminate the infectious agents by various mechanisms including phagocytoses, oxidative damage, or formation of neutrophil extracellular trap (NET). Neutropenia may be a risk factor for phaeohyphomycoses, and restoration of the neutrophil function can improve the outcome of the infection. In the present study, interaction of primary human neutrophil granulocytes with the hyphae C. lunata was examined and compared to that with the well characterized filamentous fungal pathogen Aspergillus fumigatus. Neutrophils could recognize the serum opsonized hyphae of C. lunata and attach to them. Myeloperoxidase release was also activated by a soluble factor present in the culture supernatant of the fungus. Induction of the oxidative burst was found to depend on serum opsonization of the hyphae. Although extracellular hydrogen peroxide production was induced, the fungus efficiently blocked the oxidative burst by acidifying the reaction environment. This blockage also affected the NET forming ability of the neutrophils.

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Curvularia Abscess of the Brainstem

Cited by 13 publications

References 25 publications

Fatal Curvularia brain abscess in a heart and kidney transplant recipient

Fatal Curvularia brain abscess in a heart and kidney transplant recipient

Pediatric brainstem abscess: a case-based review

Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal Pathogen Curvularia lunata

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