In this study, a technique of flux reconstruction is proposed to perform aeroacoustic computations using high-order methods on multiblock structured meshes with non-conforming grid interfaces. The use of such grids facilitates zonal mesh refinements, and flows at high Reynolds numbers can thus be simulated at a reasonable cost. The high-order methods consists of low-dissipation and low-dispersion implicit finite-volume numerical schemes. Using a flux reconstruction method, they can be applied on non-conforming grids. In a first part, the method is described. It is based on the application of non-centered spatial schemes and the use of ghost cells. The flow variables in the ghost cells are computed from the flow field in the grid cells using local meshless interpolations with radial basis functions. Then, the performance of the method is evaluated by carrying out two-dimensional simulations of vortex convection and of a mixing layer. The results show that no significant spurious acoustic waves are produced at the grid interfaces. Finally, the flux reconstruction approach is applied to the computation of a three-dimensional jet at a Mach number of 0.6 and a Reynolds number based on the jet diameter of 5.7 × 10 5. In particular, nonconforming grids are used to obtain 384 points in the azimuthal discretization in the jet shear layers, while using less points at the center of the jet. Preliminary results regarding the jet development are shown and compared with experimental data.