Cursed Duet: HIV Infection and Tuberculosis

Murray, John F.

doi:10.1159/000195844

Cited by 49 publications

(22 citation statements)

References 35 publications

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“…An estimated 8.3 million new cases of TB occurred in the year 2000, and 1.8 million deaths from TB were reported in the same year [1]. Moreover, the incidence of HIV-associated TB continues to increase [2, 3], and TB caused 11% of all adult AIDS deaths in 1997 [1]. …”

Section: Introductionmentioning

confidence: 99%

Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans

Lee

Kim

et al. 2005

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Background: The fact that only 10% of people infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) suggests the presence of genetic factors in the pathogenesis of TB. To date, a number of single nucleotide polymorphisms (SNPs) in several candidate genes have been proposed as genetic risk factors of TB; however, reports are conflicting. Objectives: We investigated whether SNPs in the interleukin (IL)-12 receptor β1 gene are associated with TB in Koreans. Methods: One hundred and fifteen patients with bacteriologically or pathologically confirmed TB and 151 healthy anonymous blood donors were enrolled. The genotypes of 5 SNPs on IL-12 receptor β1 gene, +705A/G (Q214R), +1158T/C (M365T), +1196G/C (G378R), +1637G/A (A525T) and +1664 C/T (P534S), were determined by PCR-RFLP. Results: No difference was observed between TB patients and controls in terms of the genotype frequencies of the 5 SNPs of the IL-12 receptor β1 gene or of their haplotypes. Conclusions: In view of the finding that these SNPs have been reported to be associated with TB in the Japanese and Moroccan populations, our results may reflect racial differences in genetic susceptibility to TB.

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Section: Introductionmentioning

confidence: 99%

Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans

Lee

Kim

et al. 2005

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“…In part, this was due to demographic factors like those encountered during the industrial revolution, such as displacement of populations and urbanization. More recently, the HIV\AIDS epidemic has greatly exacerbated an already grave situation in the developing world by creating a deadly synergy with tuberculosis that leads to even worse morbidity and mortality (Murray, 1990).…”

Section: Introductionmentioning

confidence: 99%

Comparative and functional genomics of the Mycobacterium tuberculosis complex a aThis review is based on the 2002 Marjory Stephenson Prize Lecture delivered by the author at the 150th Meeting of the Society for General Microbiology, 9 April 2002.

Cole

2002

Microbiology

115

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“…There are three major reasons for this relentless augmentation of a supposedly diagnosable, curable, and even preventable disease: the first reason for the soaring incidence in numerous underdeveloped countries is the widening epidemic of HIV-1 infection; as I will explain in this article, the coexistence of Mycobacterium tuberculosis and HIV-1, a veritable 'cursed duet', accelerates the development, worsens the severity, and amplifies the transmission of tuberculosis [2]. (This review will not discuss HIV-2, which is considerably less prevalent and appears to be less virulent than HIV-1; accordingly, HIV-2 has had little impact on the global epidemiology of tuberculosis.)…”

Section: Introductionmentioning

confidence: 96%

Tuberculosis and HIV Infection: A Global Perspective

Murray

1998

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The incidence of HIV-associated tuberculosis has been increasing worldwide since the beginning of the AIDS epidemic, and is expected to increase even further during the foreseeable future, especially in developing countries. There is no doubt now that, in the presence of HIV infection, new-onset tuberculous infection progresses rapidly to clinically significant disease and the likelihood that latent tuberculous infection progresses rapidly to clinically significant disease and the likelihood that latent tuberculous infection will reactivate is enormously increased. The accelerating and amplifying influence of HIV infection is contributing to the increasing incidence of disease caused by multidrug-resistant strains of Mycobacterium tuberculosis. Neither clinical features nor radiographic abnormalities reliably distinguish the majority of patients with HIV-associated tuberculosis from those without HIV infection. Some persons with HIV infection, however, present with atypical manifestations of tuberculosis and these patients may be difficult to diagnose. Six months of daily or thrice weekly chemotherapy with the usual regimen of 4 then 2 antituberculosis drugs cures most patients, but many die during or after treatment of other AIDS-related complications.

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Cursed Duet: HIV Infection and Tuberculosis

Cited by 49 publications

References 35 publications

Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans

Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans

Comparative and functional genomics of the Mycobacterium tuberculosis complex a aThis review is based on the 2002 Marjory Stephenson Prize Lecture delivered by the author at the 150th Meeting of the Society for General Microbiology, 9 April 2002.

Tuberculosis and HIV Infection: A Global Perspective

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