Curricular design for competencies in basic education in Uruguay: Positions and current debates (2008–2019)

Bordoli, Eloísa

doi:10.1080/03050068.2020.1845061

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…The validated protein structures were considered as the target structures for molecular docking analysis. The synthesized pseudopeptide was docked against the target leptospiral proteins using the PyRx 0.8 [ 25 ] virtual screening tool; it aims to anticipate the possible binding modalities of the three-dimensional structure of the complex based on the binding capabilities of the pseudopeptide and the target protein [ 26 , 27 ]. The pseudopeptide was docked using a genetic algorithm, in which the ligand undergoes conformational changes to determine the lowest energy conformation, which is the most stable structure and the most likely structure observed in in vivo systems.…”

Section: Methodsmentioning

confidence: 99%

Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach

et al. 2023

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Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adaptation to various environmental conditions has made Leptospira acquire a large genome (~4.6 Mb) and a complex outer membrane, making it unique among bacteria that mimic the symptoms of jaundice and hemorrhage. Sph2 is another important virulence factor that enhances hemolytic sphingomyelinase—capable of moving inside mitochondria—which increases the ROS level and decreases the mitochondrial membrane potential, thereby leading to cell apoptosis. In the present study, 25 suspected bovine serum samples were subjected to the Microscopic Agglutination Test (MAT) across the Mysuru region. Different samples, such as urine, serum, and aborted materials from the confirmed MAT-positive animals, were used for isolation and genomic detection by conventional PCR targeting virulence gene, Lipl32, using specific primers. Further, in vitro and in silico studies were performed on isolated cultures to assess the anti-leptospiral, anti-hemolytic, and sphingomyelinase enzyme inhibition using novel pseudopeptides. The microdilution technique (MDT) and dark field microscope (DFM) assays revealed that at a concentration of 62.5 μg/mL, the pseudopeptide inhibited 100% of the growth of Leptospira spp., suggesting its efficiency in the treatment of leptospirosis. The flow cytometry analyses show the potency of the pseudopeptide against sphingomyelinase enzymes using human umbilical vein endothelial cells (HUVECs). Thus, the present study demonstrated the efficacy of the pseudopeptide in the inhibition of the growth of Leptospira, and therefore, this can be used as an alternative drug for the treatment of leptospirosis.

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Section: Methodsmentioning

confidence: 99%

Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach

et al. 2023

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“…понимают способность человека устанавливать связи между знанием и реальной ситуацией, осуществлять принятие верного образовательного направления и вырабатывать алгоритм действий по его реализации в условиях неопределенности [12]. S. Sharma определяет универсальные умения и навыки как неспецифичные для работы в определенной профессии или отрасли, но значимые для работы, образования и жизни в целом [13]. E. Bordoli подчёркивает, что именно измерение результата формирования универсальных компетенций вызывает больше всего затруднений среди наставников цифровой школы на практике [14].…”

Section: обзор литературыunclassified

Formation of universal competencies of undergraduates during development of the plot of web-quest

Zenkina¹,

Tsygankova²,

Kharunzheva³

et al. 2021

P Sci Edu

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The problem and the aim of the study. The use of innovative technologies for the development of basic personal qualities and supra-subject competencies is a priority direction for the development of the international educational environment. Web-quest is one of the applications of the gamification technology in didactics. The authors suggest that when designing a web-quest, special attention should be paid to working with the formulation of the web-quest plot as an important factor in the formation of universal competencies of undergraduates. Research methods. To determine the sequence of training actions in the development of the plot, the principles of designing the game environment of the quest, the measurement procedures, the system-activity and competence approaches were used. The experiment involved 20 students of Vyatka State University (50% boys and 50% girls) in the specialty 44.04.01 Teacher education. Informatization of education (Master's degree level). Triggers, macros, and hyperlinks are used to implement transitions. The web quest is hosted on the OneDrive. Statistical methods: G-sign test, multiple correlation analysis. Results. During the experiment undergraduates learned to identify and design the elements of the plot; to arrange events in a chronological order of presentation; to establish a logical connection between the facts; to transform the plot into a storyline and back. The empirical value of Gemp=2<Gcr=3 (for p=0.01) obtained in the estimation procedure proves that the changes in the system are not random. The coefficient (0<R1,2,3...N=0.86<1) is calculated, confirming the positive correlation of universal competencies with undergraduates performance. The evaluation of its statistical significance was done (Femp0.01=14.47>Fcrit0.01=5.29). In conclusion we summarize the problems connected with the development on the plot of the web-quest (presentation of facts in chronological order, author's detachment, etc.) and offer recommendations for their resolution: graphic and verbal visualization, numbering of events, the use of well-known literary plots.

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“…E. Brouwer et al understand universal competencies as a human ability to see the connection between one's knowledge and a real state of affairs, to choose the right, suitable educational direction, and to make an algorithm of actions in conditions of uncertainty and doubt (Brouwer et al, 2020). S. Sharma defined universal competencies and skills as ones unspecific for any definite profession or sphere of activity, but important in work, education, and life in general (Sharma, 2020).…”

Section: Foreign Literature Reviewmentioning

confidence: 99%

“…S. Sharma defined universal competencies and skills as ones unspecific for any definite profession or sphere of activity, but important in work, education, and life in general (Sharma, 2020). E. Bordoli considers that assessing or measuring the result of forming universal competencies in practice is of greatest difficulty for digital school tutors (Bordoli, 2021).…”

Section: Foreign Literature Reviewmentioning

confidence: 99%

Formation of Universal Competencies of Undergraduates during Development of the Plot of Web-Quest

2021

European Journal of Contemporary Education

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The paper tackles the issue of using the educational web-quest technology in forming universal competencies of students of higher educational establishments.The aim of the paper is to offer a theoretical grounding and to experimentally test the efficiency of forming the theory of web-quest which helps to form students' universal competencies and improve the quality of higher education on the whole.The methodology involves the analysis of works devoted to issues and the prospects of educational informational support, stating the potential of web-quest technology for forming the necessary competencies and personal qualities. For the experimental assessment, empirical methods were used (observation, analysis of the content of web-quests, results from completing tasks, and the role of this approach in forming universal competencies).Research results. The authors specify the structure-forming and meaningful role of the story line as an element of a web-quest, the prospect of its creating to increase the quality of teaching undergraduates, its advantages and disadvantages in forming the needed competencies and personal qualities of future specialists (training program 44.04.01 Pedagogical education, profile Informatization of education (master's degree).The conclusion proves that working over forming a web-quest story line contributes to forming the students' universal competencies and necessary personal qualities, as well as to improving the quality of teaching on the whole.

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Curricular design for competencies in basic education in Uruguay: Positions and current debates (2008–2019)

Cited by 4 publications

References 7 publications

Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach

Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach

Formation of universal competencies of undergraduates during development of the plot of web-quest

Formation of Universal Competencies of Undergraduates during Development of the Plot of Web-Quest

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