Currently available biomaterials for use in cardiopulmonary bypass

Belway, Dean; Rubens, Fraser D.

doi:10.1586/17434440.3.3.345

Cited by 9 publications

(7 citation statements)

References 86 publications

(105 reference statements)

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“…Heparin binds to anti-thrombin III to prevent thrombin activation and, thereby, inhibits thrombosis. 16,18,19 When heparin is coated onto the polymer surface of the circuits, effective biocompatible coating materials such as Trillium™ (Medtronics, Minneapolis, MN) and Bioline™ (Jostra, Hirrlingen, Germany) inhibit platelet interactions with the circuit surface. 18,19 Trillium is coated with heparin, polyethylene oxide chains, and sulfate/sulfonate.…”

Section: Discussionmentioning

confidence: 99%

“…17 In other words, the coating biomaterial has hydrophobic and hydrophilic polyethylene backbones on its surface so that the artificial surface cannot easily interact with blood cells. 18,19 The control group in this study had an uncoated circuit other than a Trillium-coated oxygenator.…”

Section: Discussionmentioning

confidence: 99%

“…Each biocompatible coating material has its own unique design and effects during CPB. 13,[16][17][18][19][20][21][22] However, a comprehensive evaluation and comparison of currently available biocompatible, coated circuits has not been done to date. The aim of this study was to compare the impact of different coated, biocompatible circuits on the inflammatory response and oxidative stress in patients undergoing CABG supported with CPB.…”

Section: Introductionmentioning

confidence: 99%

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The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress

Sohn¹,

Marcoux

Mycyk

et al. 2009

Perfusion

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This study was to compare the impact of different biocompatible coated circuits on inflammatory response and oxidative stress induced during cardiopulmonary bypass (CPB). Seventy-eight patients undergoing elective coronary artery bypass grafting (CABG) with CPB were randomly assigned to five groups with different biocompatible coated circuits: Trillium, Bioline, Phosphorylcholine, Polymethoxyethyl acrylate (PMEA), and the uncoated control group. Blood was drawn at three different time points: before CPB, 6 and 72 hours post CPB. Unlike the Trillium group, serum levels of TNF-alpha in the Bioline and Phosphorylcholine groups significantly increased only at 72 hours post CPB (p < 0.05). Serum levels of IL-6 significantly increased at 6 and 72 hours post CPB in all groups (p < 0.01). The Trillium group showed a significant increase of IL-10 compared to the control group at 72 hours post CPB (p < 0.05). Serum levels of NOx in the Phosphorylcholine group significantly decreased at 6 hours post CPB compared to baseline (p < 0.05). Both the Bioline and Phosphorylcholine groups showed statistical decreases in serum NOx levels compared with other groups at 6 hours post CPB (p < 0.05). A significant difference in NOx levels between the Bioline and the control group was also observed at 72 hours post CPB. Myeloperoxidase levels were significantly elevated at 6 and 72 hours post CPB in all groups (p < 0.05). Inflammatory response and oxidative stress are elevated during CABG with CPB. Heparin-coated and the Phosphorylcholine-coated circuits induce less inflammatory responses and oxidative stress compared to other circuits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress

Sohn¹,

Marcoux

Mycyk

et al. 2009

Perfusion

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“…In the field of blood‐contacting medical devices, heparin coatings have been used for a number of decades as a technique to reduce the adverse reactions of blood to foreign materials . Many methods for attaching heparin to surfaces have been described, although only a very small number are in commercial application …”

Section: Introductionmentioning

confidence: 99%

Heparin surfaces: Impact of immobilization chemistry on hemocompatibility and protein adsorption

Gore

Andersson²,

Biran

et al. 2014

J Biomed Mater Res

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Immobilization of heparin to surfaces has been used for decades to reduce the thrombogenicity of blood contacting devices. This study evaluates how the mode of covalent heparin bonding affects the hemocompatibility and uptake of antithrombin on surfaces in whole blood. End-point attached (EPA) heparin, using the proprietary Carmeda Bioactive Surface (CBAS Surface), was compared with other methods of covalent heparin bonding that typically yield multiple covalent linkages (using reductive amination of periodate oxidized native heparin or EDC coupling of native heparin). All heparin surfaces were immobilized on flexible polyvinyl chloride tubing and exposed to fresh non-anticoagulated blood in an in vitro recirculating Chandler loop blood model. After exposure, biomarkers for coagulation and platelet activation were analyzed in the solution phase, and adsorbed plasma proteins were eluted from the heparin surfaces and measured for surface concentration of antithrombin and total adsorbed protein. Only the EPA-heparin surface conferred thromboresistance, as observed by the absence of clotting. Attachment and activation of platelets as well as activation of the clotting cascade was significantly lower on the EPA-heparin surface when compared with the other heparin surfaces. In addition, antithrombin constituted ∼40% of the total adsorbed plasma protein concentration on the EPA-heparin surfaces.

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“…The performance of blood-contacting biomedical devices (see also Chapter 10.10, Biomedical Applications) such as catheters, blood vessel grafts, vascular stents, artificial heart valves, circulatory support devices, various extracorporeal tubings, hemodialysis, hemapheresis, and oxygenator membranes is significantly impaired by these adverse reactions (18,(25)(26)(27)(28). The performance of blood-contacting biomedical devices (see also Chapter 10.10, Biomedical Applications) such as catheters, blood vessel grafts, vascular stents, artificial heart valves, circulatory support devices, various extracorporeal tubings, hemodialysis, hemapheresis, and oxygenator membranes is significantly impaired by these adverse reactions (18,(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%