Current wound healing procedures and potential care

Abstract

In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting micro RNA, and stem cell therapy. In addition, environment sensors can also potentially utilize to monitor and manage micro environment at wound site. Sensors use optical, odor, pH, and hydration sensors to detect such characteristics as uric acid level, pH, protease level, and infection – all in the hopes of early detection of complications.

Eucalyptus oil nanoemulsion-impregnated chitosan film: antibacterial effects against a clinical pathogen, Staphylococcus aureus, in vitro

“…14 Figure 2 shows the variations of the moisture content in chitosan films for increasing concentrations of nanoemulsion. It can be observed that the moisture content was lowest for films with 5% of emulsion loaded when compared with films having 0%, 1%, and 3% emulsion.…”

“…An effective means of remedy, at the wounded site is the use of antimicrobial bandages/scaffolds with which the active compound is used in minimal amounts and ensures that the healing activity is efficient at that site. 14 In recent years, application studies have focused on biodegradable films made from natural polymers in pharmaceutical and food industries. Such polymers may be proteins of plant or animal origin and biological materials.…”

Chitosan as a starting material for wound healing applications

“…Dermal wound healing is a complex biological process, which includes four overlapping steps. These are the inflammatory phase immediately after the lesion has occurred, the migratory, proliferative and maturation phase resulting in remodeling (Dreifke et al, 2015). Among other factors involved in wound healing, the extracellular matrix (ECM) has a key role in orchestrating and guiding cell phenotype, adhesion, migration and proliferation.…”

“…Acute wounds originate from superficial scratches to deep injuries and heal completely with minimal or no scars within a timeframe of 3 weeks. Chronic wounds, e.g., certain types of ulcers or diabetic wounds (Dreifke et al, 2015) start to develop when the acute wound fails to heal after a minimum time period of 3 months. Based on etiology, type, depth and clinical appearance, wounds are classified as shown in Figure 1 (Boateng et al, 2008;Kyriacos et al, 2008).…”

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

“…Wound healing is a natural process to keep the integrity of the skin of those who have been submitted to surgery or that simply have been injured [48,49]. The concept comprises not only the skin; it can be expanded to treatment of periodontal diseases [50] and cartilage regeneration [51].…”