Current Views on the Pathogenesis and Principles of External Treatment of Atopic Dermatitis in Children

Мурашкин, Н. Н.; Материкин, А. И.; Амбарчян, Э. Т.; Епишев, Р. В.

doi:10.15690/vsp.v15i6.1655

Cited by 6 publications

(1 citation statement)

References 64 publications

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“…In addition, an increase in the number of Th2-cytokine-producing lymphocytes in the affected areas with atopic dermatitis leads to increased inflammation in the skin. In a systematic review of 113 studies, no clear evidence was found of the relationship between the role of specific infections or vaccination in the manifestation of AD, but the dependence of the development of AD on the use of broad-spectrum antibiotics during pregnancy and the postpartum period was found [3].…”

Section: Formulation Of the Problemmentioning

confidence: 99%

Possibilities for Assessing the Effectiveness of Treatment of Atopic Dermatitis Based on Analysis of Color Characteristics of Video Dermatoscopic Images

Аврунин

Trubitcin

Исаева

et al. 2020

Innovative Technologies and Scientific Solutions for Industries

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The subject of the article is the study of the color characteristics of video dermatoscopic images of affected skin areas of children with atopic dermatitis and the development of an automated diagnostic system for processing and analysis of dermatoscopic images. The aim of the work is to develop an objective method for assessing the skin condition of children with atopic dermatitis based on numerical analysis of images of affected skin areas. The objectives of the work were to collect a life history of children with atopic dermatitis, study the color characteristics of video dermatoscopic images of affected skin areas and further develop an automated diagnostic system for processing and analyzing dermatoscopic information. Research Methods. During the diagnostic examinations of children with atopic dermatitis, a history of life was collected and the initial dermatological status of patients was described. A comprehensive assessment of the severity of the disease was performed using the SCORAD index. Image registration was carried out using a UM039 digital video dermatoscope with optical magnification up to 200 times, resolution of the receiving matrix 2880 × 1800 image elements, equipped with a built-in block of adjustable LED lighting, a tripod and a rotary 3-inch display. The images were captured on a microSD card with subsequent transfer of data to the database on the computer. The results of the study, based on the data obtained, allowed us to assess the intensity and dynamics of the inflammatory processes of the affected areas of the skin of children with atopic dermatitis and to formulate the principles of the automated diagnostic system for processing and analysis of dermatoscopic images. Conclusion. At the end of the study, the authors conclude that to monitor the skin condition in the treatment of atopic dermatitis, the analysis of the color components of the affected areas on the HSV scale can be used, which allows the specialist to intuitively observe the results of the therapy in a natural color space for human perception. As prospects for the development of the work, the authors substantiate the prerequisites for the development of a complete automated system for the comprehensive diagnosis of atopic dermatitis and its clinical trial. Such a system can make it possible to form a preliminary diagnosis and determine the severity of the disease based on the evaluation of color channels of images of affected skin areas and additional diagnostic data.

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Section: Formulation Of the Problemmentioning

confidence: 99%

Possibilities for Assessing the Effectiveness of Treatment of Atopic Dermatitis Based on Analysis of Color Characteristics of Video Dermatoscopic Images

Аврунин

Trubitcin

Исаева

et al. 2020

Innovative Technologies and Scientific Solutions for Industries

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Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children

Мурашкин

Намазова-Баранова

Опрятин

et al. 2020

Vopr. sovr. pediatr.

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Atopic dermatitis (AD) is the disease with chronic inflammation, epidermal barrier dysfunction and microbial dysbiosis. AD is widespread, including pediatric population. The article discusses the disease’s pathogenesis: skin barrier deficiency, immunological causes of chronic inflammation, characteristics of normal skin microbiome and its disorders on both affected and unaffected skin of children with AD. Main principles of systemic treatment for moderate and severe forms of disease are considered. Features of targeted therapy with dupilumab (IL 4/IL 13 inhibitor) in children with moderate and severe forms of AD are discussed. The overview of the research results on the dupilumab efficacy and safety is presented.

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The efficacy of calcineurin inhibitor produced in the Russian Federation in treatment of patients with atopic dermatitis

Кохан¹,

Keniksfest²,

Стукова³

2018

Klin. dermatol. venerol.

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Эффективность отечественного ингибитора кальциневрина в терапии больных атопическим дерматитом © М.М. КОХАН, Ю.В. КЕНИКСФЕСТ, Е.И. СТУКОВА ГБУ СО «Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии», Екатеринбург, Россия РЕЗЮМЕ Представлены современные данные об отдельных аспектах патогенеза атопического дерматита (АтД) и концептуальный подход к стратегии и тактике лечения, представленный в Федеральных клинических рекомендациях Российского общества дерматовенерологов и косметологов. Приведены актуальные данные о подходах к наружному лечению с использованием топических ингибиторов кальциневрина и приведены сведения об активном противовоспалительном эффекте препаратов такролимуса (мазь 0,03% и 0,1%). Дана характеристика и описаны преимущества отечественного препарата мази такролимуса 0,03% и 0,1%. Приведены результаты терапии данным препаратом больных АтД в режиме монотерапии и в составе комплексного лечения. Обобщение опыта использования мази такролимуса в терапии проявлений АтД средней и тяжелой степени свидетельствует о его выраженном позитивном характере. В статье описаны случаи эффективного применения отечественной мази (мазь такролимуса 0,03% и 0,1%), обладающей модифицированной основой, при острых и подострых воспалительных проявлениях заболевания у детей и взрослых; отмечена хорошая переносимость препарата, отсутствие серьезных нежелательных явлений и осложнений. Приведенный опыт позволяет рекомендовать мазь такролимуса для широкого клинического применения для оптимизации наружной терапии больных АтД. Ключевые слова: атопический дерматит, патогенез, наружное лечение, такролимуса мазь. Кохан М.М. -ГБУ СО «Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии», руководитель научного клинического отдела дерматологии, доктор медицинских наук, профессор, https://orcid.org/ 0000-0001-6353-6644 Кениксфест Ю.В. -ГБУ СО «Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии», ведущий научный сотрудник научного клинического отдела, доктор медицинских наук, доцент, заведующий отделения хронических дерматозов для взрослых, https://orcid.org/0000-0001-8431-5664 Стукова Е.И. -ГБУ СО «Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии», младший научный сотрудник, врач-дерматовенеролог отделения хронических дерматозов для взрослых, https://orcid.org/0000-0003-4580-7839 КАК ЦИТИРОВАТЬ: Кохан М.М., Кениксфест Ю.В., Стукова Е.И. Эффективность отечественного ингибитора кальциневрина в терапии больных атопическим дерматитом. Клиническая дерматология и венерология. 2018;17(5):66-73 https://doi. ABSTRACTWe outlined present-day knowledge on certain aspects of the pathogenesis of atopic dermatitis (AD) and modern conceptual approach to the strategy and tactics of treatment described in the Federal Clinical Guidelines of the Russian Society of Dermatovenerologists and Cosmetologists. Current data on treatment using topical calcineurin inhibitors and information on the active anti-inflammatory effect of tacrolimus (0.03 a...

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Current Views on the Pathogenesis and Principles of External Treatment of Atopic Dermatitis in Children

Cited by 6 publications

References 64 publications

Possibilities for Assessing the Effectiveness of Treatment of Atopic Dermatitis Based on Analysis of Color Characteristics of Video Dermatoscopic Images

Possibilities for Assessing the Effectiveness of Treatment of Atopic Dermatitis Based on Analysis of Color Characteristics of Video Dermatoscopic Images

Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children

The efficacy of calcineurin inhibitor produced in the Russian Federation in treatment of patients with atopic dermatitis

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